4-(4-碘-苯氧基)-苯酚 | 26002-35-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(4-碘-苯氧基)-苯酚
• 英文名称: 4-(4-iodo-phenoxy)-phenol
• 英文别名: (4-Jod-phenyl)-(4-hydroxy-phenyl)-aether；O-(4-Jod-phenyl)-hydrochinon；4-Hydroxy-1-(4-jod-phenoxy)-benzol；4-(4-Jod-phenoxy)-phenol；4-hydroxy-4'-iododiphenyl ether；4-[4-(iodo)-phenoxy]-phenol；4-(4-Iodophenoxy)-phenol；4-(4-iodophenoxy)phenol
• CAS: 26002-35-7
• 化学式: C₁₂H₉IO₂
• 分子量: 312.107
• InChiKey: SEUYXXCZJLHQTO-UHFFFAOYSA-N

物化性质

• 沸点：
  375.9±27.0 °C(Predicted)
• 密度：
  1.728±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  4-(4-碘-苯氧基)-苯酚 在 sodium hydroxide 、 potassium carbonate 作用下， 生成 D-2-[p-(p-iodophenoxy)phenoxy]-propionic acid
  参考文献：
  名称：

  CH621921

  摘要：

  公开号：
• 作为产物：
  描述：

  1-甲氧基-4-苯氧基苯 在 sodium hydroxide 、 三氯化铝 、 一氯化碘 、 溶剂黄146 作用下， 生成 4-(4-碘-苯氧基)-苯酚
  参考文献：
  名称：

  Iodo Derivatives of Phenyl Ether. II. Studies in Orientation

  摘要：

  DOI：

  10.1021/ja01265a038

文献信息

• Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors
  申请人：——

  公开号：US20040006057A1

  公开（公告）日：2004-01-08

  The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formula 1 wherein X, A, Y, B, G, W, and R 1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

  本发明涉及三芳基氧基吡啶二酮类金属蛋白酶抑制剂，其化学式为1，其中X、A、Y、B、G、W和R1如规范中所定义，并涉及用于治疗炎症、癌症和其他疾病的药物组合物和方法。
• Propionic acid oximes
  申请人：Hoffmann-La Roche Inc.

  公开号：US04365991A1

  公开（公告）日：1982-12-28

  Propionic acid oximes of the general formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of from 1 to 6 carbon atoms or cycloalkyl of from 3 to 6 carbon atoms, R.sub.2 is hydrogen, alkyl of from 1 to 6 carbon atoms, alkenyl of from 2 to 6 carbon atoms or alkynyl of from 2 to 6 carbon atoms, or R.sub.1 and R.sub.2 together with the carbon atom to which they are attached form a cyclopentane or cyclohexane ring which can be mono-, di- or trisubstituted with alkyl of from 1 to 3 carbon atoms, R.sub.3 is hydrogen, halogen or nitro with the proviso that R.sub.1 and R.sub.2 are not simultaneously hydrogen, processes for their manufacture, herbicidal compositions containing these compounds as the active ingredient and methods of use of the herbicidal compositions are disclosed.

  本发明涉及一般式为##STR1##的丙酸肟化合物，其中R.sub.1为氢、1至6个碳原子的烷基或3至6个碳原子的环烷基，R.sub.2为氢、1至6个碳原子的烷基、2至6个碳原子的烯基或2至6个碳原子的炔基，或者R.sub.1和R.sub.2与它们所连接的碳原子一起形成一个环戊烷或环己烷环，该环可以是单取代、双取代或三取代，取代基为1至3个碳原子的烷基，R.sub.3为氢、卤素或硝基，但R.sub.1和R.sub.2不能同时为氢。本发明还涉及制备这些化合物的方法、包含这些化合物作为活性成分的除草剂组合物以及使用该除草剂组合物的方法。
• Catalytic hydroxylation of arylthianthrenium salts with nitrous oxide
  作者：Shengyang Ni、Josep Cornella

  DOI：10.1016/j.tet.2023.133602

  日期：2023.9

  protocol for the conversion of aryl thianthrenium salts to the corresponding phenols, by means of a nickel catalyst and N2O. The method tolerates various functional groups and permits the hydroxylaiton of functionalized molecules. Capitalizing on the high selectivity in the introduction of the thianthrene unit in aryl groups, the method represents a formal hydroxylation of aromatic C–H bonds.

  我们提出了一种催化方案，通过镍催化剂和 N 2 O 将芳基噻烯鎓盐转化为相应的酚类。该方法可耐受各种官能团并允许官能化分子的羟基化。利用在芳基中引入噻蒽单元的高选择性，该方法代表了芳香族 C-H 键的正式羟基化。
• DE2646124
  申请人：——

  公开号：——

  公开（公告）日：——
• Selective displacement of aryl fluorides with hydroquinone: synthesis of 4-phenoxyphenols
  作者：Benjamin F. Marcune、Michael C. Hillier、Jean-François Marcoux、Guy R. Humphrey

  DOI：10.1016/j.tetlet.2005.09.025

  日期：2005.11

  The selective displacement of a variety of aryl fluorides with hydroquinone has been achieved to give substituted 4-phenoxyphenols 3. In some cases the addition of 18-crown-6 resulted in a significant rate enhancement, and the reactions could be carried out at lower temperature. One of these derivatives, 3a (X = Cl) was converted to 2-propyl-4-(4-chlorophenoxy)phenol 2a, a precursor to the PPAR gamma receptor agonist 1. (c) 2005 Elsevier Ltd. All rights reserved.