All-trans-2,4,6,8,10,12-tetradecahexaenal | 774604-49-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: All-trans-2,4,6,8,10,12-tetradecahexaenal
• 英文别名: 2,4,6,8,10,12-tetradecahexaenal；2,4,6,8,10,12-Tetradecahexaenal, (2E,4E,6E,8E,10E,12E)-；(2E,4E,6E,8E,10E,12E)-tetradeca-2,4,6,8,10,12-hexaenal
• CAS: 774604-49-8
• 化学式: C₁₄H₁₆O
• 分子量: 200.28
• InChiKey: NIWUTVYPWAQOEZ-KKRDYVQESA-N

物化性质

• 沸点：
  358.4±11.0 °C(Predicted)
• 密度：
  0.916±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  All-trans-2,4,6,8,10,12-tetradecahexaenal 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以60%的产率得到2,4,6,8,10,12-tetradecahexaenol
  参考文献：
  名称：

  醋酸醋杆菌将多共轭化合物直接转化为其相应的羧酸

  摘要：

  使用醋酸醋杆菌（Acetobacter aceti）将多共轭醛或醇转化为相应的酸。将分析结果与使用霍纳-维蒂希反应化学获得的酸进行了比较。

  DOI：

  10.1016/j.tet.2008.07.011
• 作为产物：
  描述：

  2,4-己二烯醛 在 正丁基锂 作用下， 生成 All-trans-2,4,6,8,10,12-tetradecahexaenal
  参考文献：
  名称：

  十四碳六烯醛的最低三重态

  摘要：

  已经通过电子自旋回波光谱法在磁场和零场中研究了全反式十四碳六烯醛的最低三重态T 0。已经确定了主轴的方向和精细结构张量的特征值。三重态对应于ππ*激发。在零场中，T 0主要通过上自旋子水平填充，该子水平衰减最快。T 0子级的相对能量和衰减率的比较 与先前为较短的多烯类所获得的结果表明，零场分裂和衰变速率的对数均与双键的总数成反比。

  DOI：

  10.1002/recl.19951141102

文献信息

• [EN] 1,2,4-TRIAZINES DERIVATIVES, PREPARATION THEREOF AND USE THEREOF IN HUMAN THERAPEUTICS<br/>[FR] DERIVES DE 1,2,4-TRIAZINES, PREPARATION DE CEUX-CI ET UTILISATION DE CEUX-CI DANS DES AGENTS THERAPEUTIQUES HUMAINS
  申请人：PF MEDICAMENT

  公开号：WO2005080354A1

  公开（公告）日：2005-09-01

  The invention relates to 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives of general formulae (I or II), in which in particular: R1 represents hydrogen, a linear or branched C1-C6 alkyl or alkoxy radical, a C5-C6 cycloalkyl radical, a phenyl (C1-C2) alkyl radical or a phenyl radical;-R2 represents hydrogen, a linear or branched Cl-C7 alkyl radical, or a C1-C6 alkyl radical substituted with groups such as trifluoromethyl or phenyl;- linker represents a C2-C6 alkyl chain or -(CH2)n-O- (n = 2 to 5), - R3 represents a group of general formula below for which X = O, linker can be connected to the ortho-, meta- or para-positions of the aromatic of the group R3, R4, R5, R6, R7 and R8 represent hydrogen or fluorine, R9, Rio and R11 represent hydrogen or a linear or branched Cl-C5 alkyl group, in particular R9 and Rio represent the methyl group and R11 represents hydrogen or the ethyl group.

  这项发明涉及一般式(I或II)的3,5-二氧代-(2H,4H)-1,2,4-三嗪衍生物，其中特别是：R1代表氢、线性或支链的C1-C6烷基或烷氧基、C5-C6环烷基、苯基(C1-C2)烷基或苯基；-R2代表氢、线性或支链的Cl-C7烷基，或C1-C6烷基，其上带有三氟甲基或苯基等基团；-连接物代表C2-C6烷基链或-(CH2)n-O- (n = 2至5)，- R3代表下述一般式的基团，其中X = O，连接物可以连接到R3基团的芳香环的邻位、间位或对位，R4、R5、R6、R7和R8代表氢或氟，R9、Rio和R11代表氢或线性或支链的Cl-C5烷基，特别是R9和Rio代表甲基，R11代表氢或乙基基团。
• [EN] POLYUNSATURATED LINEAR ALDEHYDES AND THEIR DERIVATIVES WITH ANTI-RADICAL AND ANTI-TUMORAL ACTIVITY<br/>[FR] ALDEHYDES LINEAIRES POLYINSATURES ET LEURS DERIVES A ACTIVITE ANTI-RADICALAIRE ET ANTI-TUMORALE
  申请人：UNIV DEGLI STUDI MILANO

  公开号：WO2003095403A1

  公开（公告）日：2003-11-20

  The invention relates to polyunsaturated linear aldehydes and derivatives thereof which can be extracted from the feathers or tissues of parrots of prepared synthetically with antioxidant, antitumoral and anti-inflammatory activity, and which are useful in the prevention and treatment of cardiovascular, inflammatory, atherosclerotic, proliferative cell and tumour damage and the prevention of alterations caused by ageing.

  本发明涉及从鹦鹉的羽毛或组织中提取或通过合成制备的多不饱和线性醛及其衍生物，具有抗氧化、抗肿瘤和抗炎活性，并可用于预防和治疗心血管、炎症、动脉粥样硬化、增生细胞和肿瘤损伤以及预防衰老引起的变化。
• Polyunsaturated linear aldehydes and their derivatives with anti-radical and anti-tumoral activity
  申请人：Stradi Riccardo

  公开号：US20050175555A1

  公开（公告）日：2005-08-11

  The invention relates to polyunsaturated linear aldehydes and derivatives thereof which can be extracted from the feathers or tissues of parrots of prepared synthetically with antioxidant, antitumoral and anti-inflammatory activity, and which are useful in the prevention and treatment of cardiovascular, inflammatory, atherosclerotic, proliferative cell and tumour damage and the prevention of alterations caused by ageing.

  本发明涉及从鹦鹉的羽毛或组织中提取或合成的多不饱和线性醛及其衍生物，具有抗氧化、抗肿瘤和抗炎活性，可用于预防和治疗心血管、炎症性、动脉粥样硬化、增殖细胞和肿瘤损伤以及预防衰老引起的变化。
• POLYUNSATURATED LINEAR ALDEHYDES AND THEIR DERIVATIVES WITH ANTI-RADICAL AND ANTI-TUMORAL ACTIVITY
  申请人：UNIVERSITA'DEGLI STUDI DI MILANO

  公开号：EP1501774A1

  公开（公告）日：2005-02-02
• POLYUNSATURATED LINEAR ALDEHYDES AND THEIR DERIVATIVES WITH ANTI-RADICAL ACTIVITY
  申请人：Giuliani S.p.A.

  公开号：EP1501774B1

  公开（公告）日：2009-08-12