2,3,5,6-Tetrafluoro-3'-trifluoromethoxy-biphenyl-4-ylamine | 867288-02-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,5,6-Tetrafluoro-3'-trifluoromethoxy-biphenyl-4-ylamine
• 英文别名: 2,3,5,6-Tetrafluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-4-amine；2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phenyl]aniline
• CAS: 867288-02-6
• 化学式: C₁₃H₆F₇NO
• 分子量: 325.186
• InChiKey: HDLXDLSDNPKUDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2,3,5,6-Tetrafluoro-3'-trifluoromethoxy-biphenyl-4-ylamine 在 吡啶 、 palladium on activated charcoal 、 氢气 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 4-hydroxy-N-[2,3,5,6-tetrafluoro-3'-trifluoromethoxybiphenyl-4-yl]-1,2,5-oxadiazole-3-carboxamide
  参考文献：
  名称：

  New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold

  摘要：

  Based on some structural analogies with leflunomide and brequinar, two well-known inhibitors of dihydroorotate dehydrogenase (DHODH), a new series of products was designed, by joining the substituted biphenyl moiety to the 4-hydroxy-1,25-oxadiazol-3-yl scaffold through an amide bridge. The compounds were studied for their DHODH inhibitory activity on rat liver mitochondrial/microsomal membranes. The activity was found to be closely dependent on the substitution pattern at the biphenyl system; the most potent products were those bearing two or four fluorine atoms at the phenyl adjacent to the oxadiazole ring. A molecular modeling study suggested that these structures might have a bre-quinar-like binding mode. The greater potency of fluorinated analogs may depend partly on enhanced interactions with the hydrophobic ubiquinone channel, and partly on the role of fluorine in stabilizing the putative bioactive conformation. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.12.038
• 作为产物：
  描述：

  4-溴-2,3,5,6-四氟苯胺 、 3-(三氟甲氧基)苯硼酸 在 potassium fluoride 、 钯 作用下， 以 甲醇 为溶剂， 反应 8.0h， 生成 2,3,5,6-Tetrafluoro-3'-trifluoromethoxy-biphenyl-4-ylamine
  参考文献：
  名称：

  Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement

  摘要：

  A novel series of DHODH inhibitors was developed based on a lead which was obtained by a docking procedure and a medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method to yield low nanomolar inhibitors. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.10.021

文献信息

• [EN] CYCLOALKENE DICARBOXYLIC ACID COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS<br/>[FR] COMPOSES D'ACIDE DICARBOXYLIQUE DE CYCLOALCENE SERVANT D'AGENTS ANTI-INFLAMMATOIRES, D'IMMUNOMODULATION ET ANTI-PROLIFERATION
  申请人：4SC AG

  公开号：WO2004056746A1

  公开（公告）日：2004-07-08

  The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein A is a non-aromatic ring system containing 4 to 8 carbon atoms, wherein the ring system comprises at least one double bond and wherein one or more of the carbon atoms in the ring can be replaced by a group X, wherein X is selected from the group consisting of S, O, N, NR4, SO, CO or SO2; D is O, S, SO2, NR4 or CH2; Z1 and Z2 are independent from each other O, S, or NR5 ; R2 is H, OR6, or NHR7; E is an alkyl or cycloalkyl group or a monocyclic or polycyclic substituted or unsubstituted ring system which may contain one or more groups X and which contains at least one aromatic ring; Y is hydrogen, halogen, haloalkyl, haloalkyloxy, alkyl, cycloalkyl, a monocyclic or polycyclic substituted or unsubstituted ring system for the use as a medicament.

  本发明涉及通式（I）的化合物及其盐和生理功能衍生物，其中A是含有4至8个碳原子的非芳香环系统，其中环系统至少包含一个双键，环中的一个或多个碳原子可以被X基团取代，其中X选自S、O、N、NR4、SO、CO或SO2组成的群；D为O、S、SO2、NR4或CH2；Z1和Z2彼此独立地为O、S或NR5；R2为H、OR6或NHR7；E为烷基或环烷基基团或可能含有一个或多个X基团的单环或多环取代或未取代环系统，其中至少含有一个芳香环；Y为氢、卤素、卤代烷基、卤代烷氧基、烷基、环烷基，用作药物的单环或多环取代或未取代环系统。
• Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds
  作者：Stefano Sainas、Agnese C. Pippione、Marta Giorgis、Elisa Lupino、Parveen Goyal、Cristina Ramondetti、Barbara Buccinnà、Marco Piccinini、Rodolpho C. Braga、Carolina H. Andrade、Mikael Andersson、Ann-Christin Moritzer、Rosmarie Friemann、Stefano Mensa、Salam Al-Karadaghi、Donatella Boschi、Marco L. Lolli

  DOI：10.1016/j.ejmech.2017.02.017

  日期：2017.3

  A new generation of potent hDHODH inhibitors designed by a scaffold-hopping replacement of the quinolinecarboxylate moiety of brequinar, one of the most potent known hDHODH inhibitors, is presented here. Their general structure is characterized by a biphenyl moiety joined through an amide bridge with an acidic hydroxyazole scaffold (hydroxylated thiadiazole, pyrazole and triazole). Molecular modelling

  此处介绍了通过脚手架替换布雷奎纳的喹啉羧酸酯部分（一种最有效的已知hDHODH抑制剂）设计的新一代有效hDHODH抑制剂。它们的一般结构的特征是联苯部分通过酰胺桥与酸性羟基唑骨架（羟基化的噻二唑，吡唑和三唑）相连。分子建模表明，这些结构应采用类似brequinar的结合模式，该模式涉及与hDHODH结合位点的亚位1、2和4的相互作用。最初，研究了化合物对重组hDHODH的抑制活性。在酶促测定中，该系列中最有效的化合物是噻二唑类似物4（IC50 16 nM）。发现该活性取决于联苯部分上的氟取代模式以及杂环的选择/取代。与每个系列（4、5和6）中的一种代表性化合物共结晶的hDHODH的结构测定证实了建模所提示的类似brequinar的结合模式。使用Jurkat细胞和PHA刺激的PBMC，在基于细胞的测定抗增殖活性的试验中测试了该化合物系列所观察到的效果的特异性。通过向培养基中添加外源尿苷也证实
• SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors
  作者：Johann Leban、Martin Kralik、Jan Mies、Michael Gassen、Karin Tentschert、Roland Baumgartner

  DOI：10.1016/j.bmcl.2005.07.053

  日期：2005.11

  Novel DHODH inhibitors were developed based on a previously described series by introduction of heteroatoms into the cyclopentene ring and hydroxyl groups attached to it. Also, the hydrophobic biphenyl side chain was replaced with benzyloxy phenyl groups. Activities on human, rat, and mouse enzymes indicate a species specificity of these inhibitors. (c) 2005 Elsevier Ltd. All rights reserved.
• DIHYDROOROTATE-DEHYDROGENASEE INHIBITORS AS VIROSTATIC COMPOUNDS
  申请人：Panoptes Pharma Ges.m.b.H.

  公开号：EP2427186B1

  公开（公告）日：2022-01-12