1,1,5,5-四苯基-3-戊酮 | 87351-03-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,1,5,5-四苯基-3-戊酮
• 英文名称: 1,1,5,5-Tetraphenyl-pentan-3-on
• 英文别名: 1,3-Dibenzhydryl-propan-2-on；Dibenzhydrylaceton；1,1,5,5-tetraphenyl-pentan-3-one；α.α'-Dibenzhydryl-aceton；γ-Oxo-α.α.ε.ε-tetraphenyl-pentan；1,1,5,5-Tetraphenylpentan-3-one
• CAS: 87351-03-9
• 化学式: C₂₉H₂₆O
• 分子量: 390.525
• InChiKey: QBCQHXTVOYBNQZ-UHFFFAOYSA-N

物化性质

• 熔点：
  100 °C(Solv: methanol (67-56-1))
• 沸点：
  518.6±19.0 °C(Predicted)
• 密度：
  1.093±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1,5,5-四苯基-3-戊酮 在 吡啶 、 甲醇 、 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 正丁基锂 、 四甲基乙二胺 、 对甲苯磺酸 、 1,2-双(二苯基膦)乙烷 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 为溶剂， -78.0~20.0 ℃ 、506.62 kPa 条件下， 反应 5.0h， 生成 1,2-carbonyldioxy-1,1-bis(2,2-diphenylethyl)-2-[1-(4-methoxyphenoxy)vinyl]ethane
  参考文献：
  名称：

  A Novel Methodology for the Synthesis of Cyclic Carbonates Based on the Palladium-Catalyzed Cascade Reaction of 4-Methoxycarbonyloxy-2-butyn-1-ols with Phenols, Involving a Novel Carbon Dioxide Elimination-Fixation Process

  摘要：

  A palladium-catalyzed CO2-recycling reaction has been developed. Reaction of 4-methoxycarbonyloxy-2-butyn-1-ols with phenols, carried out in the presence of a palladium catalyst, produces phenoxy-substituted cyclic carbonates by way of a pathway involving a CO2 elimination-fixation. A variety of propargylic alcohols and phenols participate in these reactions which yield cyclic carbonates with high efficiencies. Stereoselective construction of trans-cyclic carbonates is achieved by using nonsymmetric substrates. Highly enantioselective reactions occur when (S)-BINAP is used as a ligand. Reaction of 4-phenoxycarbonyloxy2-butyn-1-ol in the presence of the palladium catalyst yields the corresponding cyclic carbonates via a three-component decomposition-reconstruction process.

  DOI：

  10.1021/ja0340681
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 三氯化铝 、 苯 作用下， 生成 1,1,5,5-四苯基-3-戊酮
  参考文献：
  名称：

  The Reversibility of the Friedel—Crafts Condensation. The Benzal- and Dibenzal-acetones

  摘要：

  DOI：

  10.1021/ja01325a031

文献信息

• [EN] EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RECEPTEURS D'ACIDES AMINES EXCITATEURS
  申请人：ELI LILLY AND COMPANY

  公开号：WO1996007405A1

  公开（公告）日：1996-03-14

  (EN) The present invention provides compounds of formula (I) in which R is as defined in the specification, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are useful as antagonists of one or more of the actions of L-glutamate at metabotropic excitatory amino acid receptors.(FR) Cette invention concerne des composés de formule (I), dans laquelle R est tel que défini dans le descriptif, ou un ester ou amide pharmaceutiquement acceptable de ces composés qui est métaboliquement labile, ou encore un sel pharmaceutiquement acceptable de ces composés, qu'on utilise comme antagonistes d'une ou de plusieurs actions du L-glutamate au niveau des récepteurs d'acides aminés excitateurs métabotropiques.

  本发明提供了公式（I）的化合物，其中R如规范中定义，或其药物可接受的代谢易裂解酯或酰胺，或其药物可接受的盐，这些化合物是L-谷氨酸在代谢型兴奋性氨基酸受体上的一个或多个作用的拮抗剂。
• Process for the manufacture of chiral azetidinones
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0111326A1

  公开（公告）日：1984-06-20

  Manufacture of chiral azetidinones of the general formula wherein R is an amino protecting group and M ⊕ is a cation, starting from L-ascorbic acid. Several alternatives lead, over a number of novel intermediates, to a novel intermediate of the formula wherein Rand M ⊕ are as above and R90- is a leaving group, which is treated with an alkali metal carbonate or bicarbonate, whereupon the compound of formula II is recovered from the reaction The compounds of formula II are useful for preparing the new sulfazecin related antibiotic compound of the formula This new antibiotic is similar in activity to the antibiotic azthreonam and useful in treating infectious diseases caused by gram negative microorganisms, particularly P. aeruginosa.

  制造通式如下的手性氮杂环丁酮 其中 R 是氨基保护基团，M ⊕ 是阳离子，从 L-抗坏血酸开始。通过几种替代方法，经过许多新型中间体，最终得到一种新型中间体，其通式为 其中 Rand M ⊕ 如上所述，R90- 为离去基团，用碱金属碳酸盐或碳酸氢盐处理，然后从反应中回收式 II 化合物。 式 II 的化合物可用于制备新的磺胺嘧啶相关的式抗生素化合物 这种新抗生素的活性与抗生素氨曲南相似，可用于治疗由革兰阴性微生物，特别是绿脓杆菌引起的感染性疾病。
• Ims detection of chemical markers in petroleum products
  申请人：Authentix, Inc.

  公开号：EP2264130A2

  公开（公告）日：2010-12-22

  A method and composition for identifying chemically tagged petroleum products can be achieved by adding one or more chemicals to a selected petroleum product wherein the chemical is immune to extraction from the petroleum product by conventional inexpensive absorbents, cannot be removed by extraction with acids, bases, or immiscible solvents, cannot be easily oxidized, reduced or reacted with common agents, is difficult to disguise by masking with other agents, has a low polarity, and has a boiling pint in the range of the petroleum product the chemical is being added to. The presence of the chemical is determined by using ion mobility to spectroscopy.

  通过向选定的石油产品中添加一种或多种化学物质，可以实现识别化学标记石油产品的方法和组合物，其中的化学物质不会被传统的廉价吸收剂从石油产品中萃取出来，不能被酸、碱或不溶性溶剂萃取去除，不容易被氧化、还原或与普通制剂发生反应，难以用其他制剂掩盖，极性低，沸点在所添加化学物质的石油产品范围内。化学品的存在是通过离子迁移率和光谱来确定的。
• IMS detection of chemical markers in petroleum products
  申请人：——

  公开号：US20040147413A1

  公开（公告）日：2004-07-29

  A method and composition for identifying chemically tagged petroleum products can be achieved by adding one or more chemicals to a selected petroleum product wherein the chemical is immune to extraction from the petroleum product by conventional inexpensive absorbents, cannot be removed by extraction with acids, bases, or immiscible solvents, cannot be easily oxidized, reduced or reacted with common agents, is difficult to disguise by masking with other agents, has a low polarity, and has a boiling point in the range of the petroleum product the chemical is being added to. The presence of the chemical is determined by using ion mobility spectroscopy.

  通过向选定的石油产品中添加一种或多种化学物质，可以实现识别化学标记石油产品的方法和组合物，其中的化学物质不会被传统的廉价吸收剂从石油产品中萃取出来，不能被酸、碱或不溶性溶剂萃取去除，不易被氧化、还原或与普通制剂发生反应，难以用其他制剂掩盖，极性低，沸点在所添加化学物质的石油产品范围内。使用离子迁移率光谱法确定化学品的存在。
• Chodkiewicz et al., Bulletin de la Societe Chimique de France, 1958, p. 1586,1589
  作者：Chodkiewicz et al.

  DOI：——

  日期：——