acetic acid-(1-cyclopropyl-propyl ester)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acetic acid-(1-cyclopropyl-propyl ester)
• 英文别名: Essigsaeure-(1-cyclopropyl-propylester)；(+)-1-(cyclopropyl)propyl acetate；1-Acetoxy-1-cyclopropyl-propan；1-cyclopropylpropyl acetate
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: PWBPEFGRZWMBPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环丙基乙基甲酮 在 乙醇 、 sodium 作用下， 生成 acetic acid-(1-cyclopropyl-propyl ester)
  参考文献：
  名称：

  Bruylants, Recueil des Travaux Chimiques des Pays-Bas, 1909, vol. 28, p. 192

  摘要：

  DOI：

文献信息

• Catalysts for asymmetric addition of organozinc regents to aldehydes and method for preparation
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：US06362344B1

  公开（公告）日：2002-03-26

  Chiral aminoalcohol catalysts and methods for their preparation are provided. The first catalyst is prepared via selective hydrogenation of one of two benzene rings in a precursor. The aminoalcohol promotes the asymmetric addition of organozinc reagents to aldehydes to afford optically active alcohols or their esters. The second catalyst is prepared by selective dialkylation of 3-exo-aminoisoborneol with a 2-haloethyl ether. The aminoalcohol promotes the addition of organozinc reagents to aliphatic aldehydes containing a &bgr;-branch with greatly enhanced enantioselectivity relative to DAIB.

  提供手性氨醇催化剂及其制备方法。第一种催化剂是通过选择性氢化前体中的两个苯环之一制备的。氨醇促进有机锌试剂对醛的不对称加成，生成光学活性醇或其酯。第二种催化剂是通过选择性对3-外氨基异螺烷基与2-卤乙基醚进行二烷基化制备的。氨醇促进对含有β-支链的脂肪族醛的有机锌试剂加成，相对于DAIB具有大大增强的对映选择性。
• Catalysts for asymmetric addition of organozinc reagents to aldehydes and method for preparation
  申请人：DuPont Pharmaceuticals Company

  公开号：US06187918B1

  公开（公告）日：2001-02-13

  Novel chiral aminoalcohol catalysts and methods for their preparation are provided. The first catalyst is prepared via selective hydrogenation of one of two benzene rings in a precursor. The aminoalcohol promotes the asymmetric addition of organozinc reagents to aldehydes to afford optically active alcohols or their esters. The second catalyst is prepared by selective dialkylation of 3-exo-aminoisoborneol with a 2-haloethyl ether. The aminoalcohol promotes the addition of organozinc reagents to aliphatic aldehydes containing a &bgr;-branch with greatly enhanced enantioselectivity relative to DAIB.

  提供了新型手性氨醇催化剂及其制备方法。第一种催化剂是通过对前体中的两个苯环中的一个进行选择性氢化制备的。氨醇促进有机锌试剂对醛的不对称加成，以得到光学活性醇或其酯。第二种催化剂是通过3-外共轭氨基异藁醇与2-卤乙基醚的选择性二烷基化制备的。氨醇促进对含有β-支链的脂肪族醛的有机锌试剂的加成，相对于DAIB具有大大增强的对映选择性。
• Stabilized cyclopropyl cation. Synthesis and solvolysis of 1-chlorobicyclopropyl
  作者：John A. Landgrebe、Larry Wayne Becker

  DOI：10.1021/ja01004a033

  日期：1968.1
• US6187918B1
  申请人：——

  公开号：US6187918B1

  公开（公告）日：2001-02-13
• US6362344B1
  申请人：——

  公开号：US6362344B1

  公开（公告）日：2002-03-26