2-phenyl-4-methoxymethyl-1,3-dioxolane | 90904-26-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-phenyl-4-methoxymethyl-1,3-dioxolane
• 英文别名: 4-(1-methoxymethyl)-2-phenyl-1,3-dioxolane；4-methoxymethyl-2-phenyl-[1,3]dioxolane；4-Methoxymethyl-2-phenyl-[1,3]dioxolan；2-phenyl-4-methoxymethyl-1,3-dioxolan；2-Phenyl 4-methoxymethyl 1,3-dioxolane；4-(methoxymethyl)-2-phenyl-1,3-dioxolane
• CAS: 90904-26-0
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: XRCNTWXLLFNXRS-UHFFFAOYSA-N

物化性质

• 沸点：
  290.1±30.0 °C(Predicted)
• 密度：
  1.085±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-phenyl-4-methoxymethyl-1,3-dioxolane 在 三乙基硅烷 、 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以2.862 g的产率得到1-苯基甲基-3-甲氧基-1,2-丙二醇
  参考文献：
  名称：

  TiCl 4催化的1-烷氧基甲基-6,8-二氧杂双环[3.2.1]辛烷的亲核裂解形成新的环氧丙烷

  摘要：

  在6,8-二氧杂双环[3.2.1]辛烷系统的C1位置引入烷氧基甲基可以在TiCl 4催化的缩醛裂解反应中新形成环氧丙烷化合物。

  DOI：

  10.1016/s0040-4020(00)00009-0
• 作为产物：
  描述：

  苯甲醛甘油缩醛 以75%的产率得到2-phenyl-4-methoxymethyl-1,3-dioxolane
  参考文献：
  名称：

  Glycerol derivatives, and therapeutical compositions containing them

  摘要：

  这项发明涉及一般式Ia、Ib和Ic的甘油衍生物##STR1##其中R.sub.1、R.sub.2、R.sub.3、A和Y代表各种取代基，以及所述化合物的制备方法和含有相同化合物的治疗组合物。

  公开号：

  US05116992A1

文献信息

• 2,2′-Bipyridinium chlorochromate/m-chloroperbenzoic acid-mediated cleavage of cyclic acetals to hydroxyesters
  作者：Frederick A. Luzzio、Rhiana A. Bobb

  DOI：10.1016/s0040-4039(97)00203-7

  日期：1997.3

  Benzylidene acetals are cleaved to hydroxyesters by means of a reagent system composed of 2,2′-bipyridinium chlorochromate (BPCC) and m-chloroperbenzoic acid. Oxidative cleavage of a 4,6-O-benzylidene glucose derivative affords a 6-O-benzoyl derivative.

  亚苄基缩醛的2,2'-联吡啶鎓氯铬酸盐（BPCC）组成的试剂系统的手段裂解的羟基酯和中号氯过苯甲酸。4，6-O-亚苄基葡萄糖衍生物的氧化裂解得到6-O-苯甲酰基衍生物。
• Process of preparing by condensation certain
  申请人：Delalande S.A.

  公开号：US05235063A1

  公开（公告）日：1993-08-10

  The derivatives of the formula: ##STR1## wherein: R.sub.1 is H or C.sub.1 -C.sub.4 alkyl; X is an oxygen atom, a methylene group or a --CH.dbd.CH-- group; n is 1 or 2 when X is an oxygen atom or a methylene group and is 0 or 1 when X is a --CH.dbd.CH-- group; R.sub.3 is a C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.7 cycloalkyl, phenyl, benzyl, CHF.sub.2, CF.sub.3 or CF.sub.3 CF.sub.2 group; each of R.sub.2 and R'.sub.2 independently is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl, C.sub.4 -C.sub.7 cycloalkyl, phenyl or benzyl group; R'.sub.2 and R.sub.3 may further form together a --(CH.sub.2).sub.3 -- or --(CH.sub.2).sub.4 -- chain; and each of R.sub.4 and R'.sub.4 independently is a C.sub.1 -C.sub.4 alkyl group or R.sub.4 and R'.sub.4 form together either a --(CH.sub.2).sub.2 -- or --(CH.sub.2).sub.3 -- chain, a --(CH.sub.2).sub.2 -- or --(CH.sub.2).sub.3 -- chain substituted by one or two C.sub.1 -C.sub.4 alkyl groups, or a --(CH.sub.2).sub.2 -- chain substituted by one or two --CH.sub.2 --NH.sub.2 groups or by one or two --CH.sub.2 --NH.sub.2 groups N-substituted by one or two C.sub.1 -C.sub.4 alkyl groups, useful as drugs.

  该公式的衍生物：##STR1## 其中：R.sub.1为H或C.sub.1-C.sub.4烷基；X为氧原子，亚甲基或--CH.dbd.CH--基团；当X为氧原子或亚甲基时，n为1或2，当X为--CH.dbd.CH--基团时，n为0或1；R.sub.3为C.sub.1-C.sub.4烷基，C.sub.3-C.sub.7环烷基，苯基，苄基，CHF.sub.2，CF.sub.3或CF.sub.3 CF.sub.2基团；R.sub.2和R'.sub.2各自独立地为氢原子或C.sub.1-C.sub.4烷基，C.sub.4-C.sub.7环烷基，苯基或苄基；R'.sub.2和R.sub.3还可以共同形成一个--(CH.sub.2).sub.3--或--(CH.sub.2).sub.4--链；R.sub.4和R'.sub.4各自独立地为C.sub.1-C.sub.4烷基，或者R.sub.4和R'.sub.4共同形成一个--(CH.sub.2).sub.2--或--(CH.sub.2).sub.3--链，一个被一个或两个C.sub.1-C.sub.4烷基取代的--(CH.sub.2).sub.2--或--(CH.sub.2).sub.3--链，或一个被一个或两个--CH.sub.2--NH.sub.2基团或被一个或两个C.sub.1-C.sub.4烷基取代的--CH.sub.2--NH.sub.2基团取代的--(CH.sub.2).sub.2--链，可用作药物。
• 3-Aryloxazolidinone derivatives, process for their preparation and their
  申请人：Delalande S.A.

  公开号：US05036090A1

  公开（公告）日：1991-07-30

  The derivatives of the formula: ##STR1## wherein: R.sub.1 is H or C.sub.1 -C.sub.4 alkyl; X is an oxygen atom, a methylene group or a --CH.dbd.CH-- group; n is 1 or 2 when X is an oxygen atom or a methylene group and is 0 or 1 when X is a --CH.dbd.CH-- group; R.sub.3 is a C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.7 cycloalkyl, phenyl, benzyl, CHF.sub.2, CF.sub.3 or CF.sub.3 CF.sub.2 group; each of R.sub.2 and R'.sub.2 independently is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl, C.sub.4 -C.sub.7 cycloalkyl, phenyl or benzyl group; R'.sub.2 and R.sub.3 may further form together a --(CH.sub.2).sub.3 -- or --(CH.sub.2).sub.4 -- chain; and each of R.sub.4 and R'.sub.4 independently is a C.sub.1 -C.sub.4 alkyl group or R.sub.4 and R'.sub.4 form together either a --(CH.sub.2).sub.2 -- or --(CH.sub.2).sub.3 -- chain, a --(CH.sub.2).sub.2 -- or --(CH.sub.2).sub.3 -- chain substituted by one or two C.sub.1 -C.sub.4 alkyl groups, or a --(CH.sub.2).sub.2 -- chain substituted by one or two --CH.sub.2 --NH.sub.2 groups or by one or two --CH.sub.2 --NH.sub.2 groups N-substituted by one or two C.sub.1 -C.sub.4 alkyl groups, useful as drugs.

  该公式的衍生物：## STR1 ## 其中：R.sub.1是H或C.sub.1-C.sub.4烷基；X是氧原子，亚甲基基团或--CH.dbd.CH--基团；当X为氧原子或亚甲基基团时，n为1或2，当X为--CH.dbd.CH--基团时，n为0或1；R.sub.3是C.sub.1-C.sub.4烷基，C.sub.3-C.sub.7环烷基，苯基，苄基，CHF.sub.2，CF.sub.3或CF.sub.3CF.sub.2基团；R.sub.2和R'.sub.2各自独立地是氢原子或C.sub.1-C.sub.4烷基，C.sub.4-C.sub.7环烷基，苯基或苄基；R'.sub.2和R.sub.3还可以一起形成--(CH.sub.2).sub.3--或--(CH.sub.2).sub.4--链；每个R.sub.4和R'.sub.4独立地是C.sub.1-C.sub.4烷基或R.sub.4和R'.sub.4一起形成--(CH.sub.2).sub.2--或--(CH.sub.2).sub.3--链，一种--(CH.sub.2).sub.2--或--(CH.sub.2).sub.3--链，被一或两个C.sub.1-C.sub.4烷基取代，或被一或两个--CH.sub.2--NH.sub.2基团或被一或两个--CH.sub.2--NH.sub.2基团N-取代的C.sub.1-C.sub.4烷基取代，可用作药物。
• Glycerol valorization: Development of selective protocols for acetals production through tailor-made macroreticular acid resins
  作者：Assunta Marrocchi、Valeria Trombettoni、Filippo Campana、Valerio Passagrilli、Alireza Nazari、Maria Paola Bracciale、Maria Laura Santarelli、Luigi Vaccaro

  DOI：10.1016/j.cattod.2022.08.018

  日期：2022.8

  Bio-based glycerol and aldehydes have been valorised by acetalization reaction over novel macroporous sulfonated polystyrene-type resins (MR-SP20-SO3H and MR-SP50-SO3H). The influence of reactants molar ratio, catalyst amount, temperature, and reaction time on the activity and selectivity to acetals have been investigated. Results showed that MR-SP20-SO3H and MR-SP50-SO3H confirm a high performance

  生物基甘油和醛已通过缩醛化反应在新型大孔磺化聚苯乙烯型树脂（MR-SP20-SO 3 H 和 MR-SP50-SO 3 H）上获得价值。研究了反应物摩尔比、催化剂用量、温度和反应时间对缩醛活性和选择性的影响。结果表明，MR-SP20-SO 3 H 和 MR-SP50-SO 3 H 证实了在甘油衍生物 1,2-丙二醇、1,3-丙二醇、3-甲氧基-1,2-丙二醇的缩醛化中的高性能和单醋精；这些催化系统可实现回收和再利用。
• Sugar free confectionery; methods of making same; and use in preparing multilayered confectionery.
  申请人：Cadbury Adams USA LLC

  公开号：EP2316279A1

  公开（公告）日：2011-05-04

  Disclosed are sugar free confectionery products, methods of making, and multilayer structures prepared from the confectionery products and chewing gum.

  本发明公开了无糖糖果产品、制作方法以及由糖果产品和口香糖制备的多层结构。