5-isopropyl-2-methyl-2,3-dihydro-pyrrole | 90203-91-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 5-isopropyl-2-methyl-2,3-dihydro-pyrrole
• 英文别名: 5-Isopropyl-2-methyl-2,3-dihydro-pyrrol；2-methyl-5-propan-2-yl-2,3-dihydro-1H-pyrrole
• CAS: 90203-91-1
• 化学式: C₈H₁₅N
• 分子量: 125.214
• InChiKey: KKTYNSJGDDKTHC-UHFFFAOYSA-N

物化性质

• 沸点：
  183.9±10.0 °C(Predicted)
• 密度：
  0.845±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-isopropyl-2-methyl-2,3-dihydro-pyrrole 生成 5-isopropyl-1,2-dimethyl-2,3-dihydro-pyrrole
  参考文献：
  名称：

  Wallach; Meyer,H.; Mittelstenscheid, Justus Liebigs Annalen der Chemie, 1901, vol. 319, p. 113

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 水 、 溴 作用下， 生成 5-isopropyl-2-methyl-2,3-dihydro-pyrrole
  参考文献：
  名称：

  Wallach, Justus Liebigs Annalen der Chemie, 1899, vol. 309, p. 29

  摘要：

  DOI：

文献信息

• NOVEL BENZYLAMINO SUBSTITUTED PYRIDOPYRIMIDINONES AND DERIVATIVES AS SOS1 INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20190194192A1

  公开（公告）日：2019-06-27

  The present invention encompasses compounds of formula (I) wherein the groups R 1 to R 4 , A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

  本发明涵盖了式(I)中的化合物，其中基团R1至R4、A和p的含义如索赔和规范中所述，它们作为SOS1的抑制剂的用途，含有这类化合物的药物组合物，以及它们作为药物/医疗用途的用途，特别是作为治疗和/或预防肿瘤疾病的药剂。
• [EN] NEW MACROCYCLIC COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS MACROCYCLIQUES ET LEURS DÉRIVÉS UTILISÉS EN TANT QU'INHIBITEURS D'EGFR
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2020260252A1

  公开（公告）日：2020-12-30

  The present invention encompasses compounds of formula (I) wherein the groups R1 to R3, A, B and L and p and q have the meanings given in the claims and specification, their use as inhibitors of mutant EGFR, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

  本发明涵盖了式（I）中的化合物，其中基团R1至R3、A、B和L以及p和q具有声明和规范中给定的含义，它们作为突变EGFR的抑制剂的用途，含有这类化合物的药物组合物以及它们作为药物/医用品的用途，特别是作为治疗和/或预防肿瘤疾病的药物。
• Benzylamino substituted pyridopyrimidinones and derivatives as SOS1 inhibitors
  申请人：Boehringer Ingelheim International GmbH

  公开号：US10829487B2

  公开（公告）日：2020-11-10

  The present invention encompasses compounds of formula (I) wherein the groups R1 to R4, A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

  本发明包括式 (I) 的化合物 其中基团 R1 至 R4、A 和 p 具有权利要求和说明书中给出的含义；它们作为 SOS1 抑制剂的用途；含有此类化合物的药物组合物；以及它们作为药物/医疗用途，特别是作为治疗和/或预防肿瘤疾病的药物的用途。
• 6-amino-quinolinone compounds and derivatives as BCL6 inhibitors
  申请人：Boehringer Ingelheim International GmbH

  公开号：US11001570B2

  公开（公告）日：2021-05-11

  The present invention encompasses compounds of formula (I), wherein the groups R1 to R5, X, Y and W have the meanings given in the claims and specification, their use as inhibitors of BCL6, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.

  本发明包括式（I）化合物（其中基团 R1 至 R5、X、Y 和 W 具有权利要求书和说明书中给出的含义）、其作为 BCL6 抑制剂的用途、含有此类化合物的药物组合物以及其作为药物的用途，特别是作为治疗和/或预防肿瘤疾病的药物。
• Process for the manufacture of 6-alkynyl-pyridine derivatives
  申请人：BOEHRINGER INGELHEIM INTERNATIONAL GMBH

  公开号：US11053237B2

  公开（公告）日：2021-07-06

  The application includes a description of novel intermediates, of new manufacturing steps resulting in a novel and improved process for producing the intermediates and the final compounds, i.e., 6-alkynyl-pyridine derivatives. The intermediates of the invention are useful to produce 6-alkynyl-pyridine derivatives, which compounds are useful for the treatment of cancer.

  该申请包括对新型中间体、新生产步骤的描述，这些新生产步骤产生了生产中间体和最终化合物（即 6-炔基吡啶衍生物）的新型改进工艺。本发明的中间体可用于生产 6-炔基吡啶衍生物，这种化合物可用于治疗癌症。