2-((diallylamino)methyl)phenol | 60405-97-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((diallylamino)methyl)phenol
• 英文别名: 2-diallylaminomethylphenol；2-Diallylaminomethyl-phenol；2-[[bis(prop-2-enyl)amino]methyl]phenol
• CAS: 60405-97-2
• 化学式: C₁₃H₁₇NO
• 分子量: 203.284
• InChiKey: GGCJPFXOYISGOD-UHFFFAOYSA-N

物化性质

• 沸点：
  130 °C(Press: 0.4 Torr)
• 密度：
  1.013±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-((diallylamino)methyl)phenol 在 水 作用下， 以 various solvent(s) 为溶剂， 生成 水杨醇
  参考文献：
  名称：

  Kinetics of hydrolysis of o-aminomethylphenols and their ammonium salts

  摘要：

  DOI：

  10.1007/bf00954412
• 作为产物：
  描述：

  2-[N-(prop-2'-enyl)aminomethyl]phenol 、 3-溴丙烯 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以82%的产率得到2-((diallylamino)methyl)phenol
  参考文献：
  名称：

  Synthesis of Novel α-Substituted and α,α-Disubstituted Amino Acids by Rearrangement of Ammonium Ylides Generated from Metal Carbenoids

  摘要：

  [GRAPHICS]A new and general four-step synthesis of protected alpha-substituted and alpha,alpha-disubstituted amino acids has been developed. The key step involves intramolecular ammonium ylide generation from a copper carbenoid with concomitant [2,3] rearrangement. The aromatic template serves as a tether, protecting group, and activating group for peptide coupling. The ylide rearrangement products can be converted into protected cyclic amino acids by ring-closing metathesis.

  DOI：

  10.1021/ol017240j

文献信息

• HETEROARYL DERIVATIVES AND USES THEREOF
  申请人：Jacobus Pharmaceutical Company, Inc.

  公开号：US20140135320A1

  公开（公告）日：2014-05-15

  The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium , including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.

  本发明涉及抗疟疾化合物及其用于对抗疟原虫属Plasmodium的使用，包括对抗药物耐药Plasmodia菌株的使用。本发明还涉及含有这种化合物的组合物以及制备这些化合物的方法。
• Aryl Derivatives And Uses Thereof
  申请人：Jacobus Pharmaceutical Company, Inc

  公开号：US20140135360A1

  公开（公告）日：2014-05-15

  The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium , including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.

  本发明涉及抗疟疾化合物及其用于对抗疟原虫属Plasmodium，包括耐药性Plasmodia菌株的用途。本发明还涉及含有这种化合物的组合物以及制备这些化合物的方法。
• Brønsted acid catalysed chemo- and <i>ortho</i>-selective aminomethylation of phenol
  作者：Zhiqiong Tang、Dongdong Li、Yidi Yue、Dan Peng、Lu Liu

  DOI：10.1039/d1ob00820j

  日期：——

  We have developed a Brønsted acid catalysed highly ortho-selective functionalization of free phenols with readily available N,O-acetals under mild conditions, furnishing various corresponding aminomethylated phenol products in moderate to excellent yields. The salient features of this transformation include mild conditions, good substrate scope, excellent ortho-selectivity, high efficiency, and ease

  我们开发了一种布朗斯台德酸催化的游离酚的高度邻位选择性官能化，在温和条件下易于获得N，O-缩醛，以中等至优异的产率提供各种相应的氨甲基化苯酚产品。这种转化的显着特点包括条件温和、底物范围好、邻位选择性好、效率高、易于进一步转化。
• [EN] HETEROARYL DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS HÉTÉROARYLES ET LEURS UTILISATIONS
  申请人：JACOBUS PHARMACEUTICAL COMPANY INC

  公开号：WO2014074775A1

  公开（公告）日：2014-05-15

  The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.

  本发明涉及抗疟疾化合物及其对疟原虫属Plasmodium的使用，包括抗药性Plasmodia菌株。本发明还涉及含有这种化合物的组合物以及制备这种化合物的过程。
• PPE copolymers, preparation thereof, and resin composition utilizing the same
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：US20030225220A1

  公开（公告）日：2003-12-04

  PPE copolymers comprise three repeating units. The PPE copolymers are polymerized with 2,6-DMP, dialkenylamide or dialkenylamine phenol, and another phenol derivative. A resin composition having a low cross-linking temperature is also disclosed, which comprises the PPE copolymer and a free radical initiator.

  PPE 共聚物包含三个重复单元。PPE 共聚物与 2,6-DMP、二烯基酰胺或二烯基胺酚以及另一种酚衍生物共聚。还公开了一种低交联温度的树脂组合物，其中包括 PPE 共聚物和自由基引发剂。