2-Butoxymethyl-tetrahydro-furan | 19114-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 2-Butoxymethyl-tetrahydro-furan
• 英文别名: Furan, 2-(butoxymethyl)tetrahydro-；2-(butoxymethyl)oxolane
• CAS: 19114-88-6
• 化学式: C₉H₁₈O₂
• 分子量: 158.241
• InChiKey: PGZISVXTYZWYPK-UHFFFAOYSA-N

物化性质

• 沸点：
  194.5-196 °C(Press: 723 Torr)
• 密度：
  0.9150 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 储存条件：
  2-8℃

SDS

2-(丁氧甲)四氫呋喃MSDS英文版

反应信息

• 作为产物：
  描述：

  四氢糠醇 、 正溴丁烷 在 氢氧化钾 作用下， 生成 2-Butoxymethyl-tetrahydro-furan
  参考文献：
  名称：

  ALPHA-TETRAHYDROFURFURYL CHLORIDE AND ALPHA-TETRAHYDROFURFURYL ETHERS

  摘要：

  DOI：

  10.1021/ja01371a034

文献信息

• Catalytic Transfer Hydrogenation of Furfural over CuNi@C Catalyst Prepared from Cu–Ni Metal-Organic Frameworks
  作者：Feng Li、Shanshan Jiang、Yue Wang、Jin Huang、Cuiqin Li

  DOI：10.1134/s0036024421010143

  日期：2021.1

  between Cu and Ni in the CuNi@C significantly enhanced the furfural transfer hydrogenation activity and raised the furfural selectivity. The reaction conditions of furfural transfer hydrogenation such as catalyst dosage, hydrogen donor, reaction temperature, and reaction time were studied. The catalytic mechanism for CTH of FF over CuNi@C catalyst was discussed.

  摘要 以1,3,5-三羧酸苯（H 3 BTC）为有机配体，通过溶剂热法制备Cu / Ni基金属有机骨架（CuNi @ BTC），然后在N 2下煅烧气氛下形成C涂层的CuNi催化剂（CuNi @ C）。TEM表明，CuNi @ C表面的碳材料为石墨烯状结构。然后，以醇为氢供体，对由CuNi @ C催化的糠醛的转移加氢进行了测试，以优化Cu：Ni比，金属：有机配体比，溶剂热合成和煅烧条件。发现在CuNi @ C中Cu和Ni之间的强协同作用显着增强了糠醛转移氢化活性并提高了糠醛选择性。研究了糠醛转移加氢的反应条件，如催化剂用量，氢供体，反应温度和反应时间。讨论了CuNi @ C催化剂上FF对CTH的催化机理。
• [EN] CATALYTIC SYNTHESIS OF REDUCED FURAN DERIVATIVES<br/>[FR] SYNTHÈSE CATALYTIQUE DE DÉRIVÉS DE FURANE RÉDUITS
  申请人：ARCHER DANIELS MIDLAND CO

  公开号：WO2014175989A1

  公开（公告）日：2014-10-30

  The present invention relates to catalytic synthesis of furan derivatives from alkoxymethylfurfural ethers or acyloxymethylfurfural esters. More particularly, the invention pertains to furan derivatives obtained by use of a multifunctional catalyst system to carry out both hydrogenation of furan starting material and hydrolysis of the reduced furan derivative in a single reaction. The process allows recovering and recycling of alcohol or acid from the reaction product.

  本发明涉及利用多功能催化剂系统从烷氧甲基糠醛醚或酰氧甲基糠醛酯合成呋喃衍生物。更具体地，该发明涉及通过使用多功能催化剂系统，在单一反应中既进行糠醛起始原料的加氢，又进行还原后的呋喃衍生物的水解，从而获得呋喃衍生物。该过程允许从反应产物中回收和循环利用醇或酸。
• Alkylation of amines and amides
  申请人：ETHYL CORPORATION

  公开号：EP0240631A1

  公开（公告）日：1987-10-14

  The invention provides the use of a B-subgroup metal oxide alkylation catalyst in alkylating an amino or amido group-containing compound using an ether alkylation agent. Thus, amines and amides may be N,N-cyclodialkylated by reaction with an unstrained cyclic ether in the presence of a B-subgroup metal oxide alkylation catalyst, preferably a Group IV-B metal oxide such as titanium dioxide.

  本发明提供了在使用醚烷基化剂烷基化含氨基或酰胺基化合物时使用B族金属氧化物烷基化催化剂的方法。因此，在B族金属氧化物烷基化催化剂的存在下，可以通过与非张力环状醚反应来进行氨基和酰胺的N,N-环状烷基化，最好使用IV-B族金属氧化物如二氧化钛。
• Synthesis of beta-L-2-Deoxy nucleosides
  申请人：Novartis AG

  公开号：EP2157095A2

  公开（公告）日：2010-02-24

  An improved process for the preparation of 2'-modified nucleosides and 2'-deoxynucleosides, such as, β-L-2'-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2'-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2' anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2'-anhydro-1-furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2'-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2'-deoxynucleosides in good yields. The compounds made according to the present invention may be used as intermediates in the preparation of other nucleoside analogues, or may be used directly as antiviral and/or antineoplastic agents.

  本发明提供了一种改进的方法，用于制备2'-修饰核苷和2'-去氧核苷，例如β-L-2'-去氧胸腺嘧啶（LdT）。特别是，改进的方法针对合成一种2'-去氧核苷，该方法可以利用不同的起始材料，但是通过氯代糖中间体或2,2'无水-1-呋喃基-核碱中间体进行。当使用2,2'-无水-1-呋喃基碱中间体时，采用还原剂（如Red-Al）和隔离剂（如15-冠-5醚），引起分子内位移反应并形成所需的核苷产物，产率良好。本发明的另一种替代方法利用无隔离剂的2,2'-无水-1-呋喃基碱中间体，以获得良好的2'-去氧核苷收率。根据本发明制备的化合物可以用作制备其他核苷类似物的中间体，或者可以直接用作抗病毒和/或抗肿瘤剂。
• Absorption refrigerant compositions for use in absorption refrigeration systems
  申请人：Daikin Kogyo Co., Ltd.

  公开号：EP0030127A1

  公开（公告）日：1981-06-10

  An absorption refrigerant composition for use in absorption refrigeration systems comprising 1,1,1,2-tetrafluoroethane and an organic solvent capable of dissolving the ethane.

  一种用于吸收式制冷系统的吸收式制冷剂组合物，由 1,1,1,2-四氟乙烷和一种能溶解乙烷的有机溶剂组成。