2-(2-furyl)-1-phenylethan-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-furyl)-1-phenylethan-1-ol
• 英文别名: 2-(Furan-2-yl)-1-phenylethanol
• 化学式: C₁₂H₁₂O₂
• 分子量: 188.226
• InChiKey: VKTAFEHMHABLII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-furyl)-1-phenylethan-1-ol 在 2-碘酰基苯甲酸 作用下， 以 二甲基亚砜 为溶剂， 生成 phenacyl-2 furanne
  参考文献：
  名称：

  呋喃和噻吩与α,β-不饱和醛通过双重活化的化学和区域选择性不对称弗里德尔-克来福特反应

  摘要：

  已经开发了一种高度化学和区域选择性的呋喃和噻吩的 Friedel-Crafts 烷基化反应，该反应依赖于远程共轭 Mukaiyama 甲硅烷基烯醇醚基序的活化。在公认的手性仲胺亚胺离子催化下，与 α,β-不饱和醛反应通常可以获得优异的对映选择性。

  DOI：

  10.1055/s-0036-1588831
• 作为产物：
  描述：

  2-呋喃甲酰肼 在 potter's clay 、 铂 2-甲基呋喃 、 氢氧化钾 、 tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato)ytterbium 、 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 生成 2-(2-furyl)-1-phenylethan-1-ol
  参考文献：
  名称：

  Kishner's Reduction of 2-Furylhydrazone Gives 2-Methylene-2,3-dihydrofuran, a Highly Reactive Ene in the Ene Reaction

  摘要：

  The Kishner reduction of 2-furylhydrazone gives 2-methylene-2,3-dihydrofuran as the major abnormal reduction product. 2-Methylene-2,3-dihydrofuran is an excellent ene in the carbonyl-ene reaction, reacting with a variety of aldehydes. Most notable was the asymmetric carbonyl-ene reaction of 2-methylene-2,3-dihydrofuran and decanal using Ti(OCH(CH3)(2))(4)/(S)-BINOL to give the corresponding alcohol in 66% yield and 94% ee. The reaction of 2-methylene-2,3-dihydrofuran with 2 equiv of 1,4-benzoquinone unexpectedly gave a monoalkylated 1,4-hydroquinone/1,4-benzoquinone electron donor-acceptor complex.

  DOI：

  10.1021/jo0479112

文献信息

• Asymmetric transfer hydrogenation of heterocycle-containing acetophenone derivatives using N-functionalised [(benzene)Ru(II)(TsDPEN)] complexes
  作者：Jonathan Barrios-Rivera、Yingjian Xu、Guy J. Clarkson、Martin Wills

  DOI：10.1016/j.tet.2021.132562

  日期：2022.1

  The application of enantiomerically-pure ruthenium(II) catalysts containing N - functionalised TsDPEN ligand to the asymmetric transfer hydrogenation of 15 examples of α-heterocyclic acetophenone derivatives is reported. Products of up to 99% ee were formed.

  报道了含有 N-官能化 TsDPEN 配体的对映体纯钌 (II) 催化剂在 15 个 α-杂环苯乙酮衍生物实例的不对称转移氢化中的应用。形成高达 99% ee 的产物。
• INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF
  申请人：Deziel Robert

  公开号：US20080146623A1

  公开（公告）日：2008-06-19

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制组蛋白去乙酰化酶的技术。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物、前药及其方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
• Inhibitors of histone deacetylase and prodrugs thereof
  申请人：MethylGene Inc.

  公开号：EP2573069A2

  公开（公告）日：2013-03-27

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及组蛋白去乙酰化酶的抑制。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物、其原药和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
• Gold catalysis: benzanellation versus alkylidenecyclopentenone synthesis
  作者：A. Stephen K. Hashmi、Michael Wölfle

  DOI：10.1016/j.tet.2009.08.074

  日期：2009.10

  A series of different furan-yn-ols were prepared by a three-step sequence. Their reaction with Gagosz's catalyst Ph3PAuNTf2 depends strongly on the substitution pattern of the Substrate and the quality of the leaving group. Benzofurans, alkylidenecyclopentenones or Meyer-Schuster type products can be obtained. Improving the leaving group quality leads to the preferred formation of benzofurans. (C) 2009 Elsevier Ltd. All rights reserved.
• US8796330B2
  申请人：——

  公开号：US8796330B2

  公开（公告）日：2014-08-05