1-(2-甲氧基乙基)吡咯烷-2,5-二酮 | 56058-13-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1-(2-甲氧基乙基)吡咯烷-2,5-二酮
• 英文名称: 1-(2-methoxyethyl)-2,5-pyrrolidenedione
• 英文别名: 1-(2-methoxyethyl)-2,5-pyrrolidinedione；2,5-Pyrrolidinedione, 1-(2-methoxyethyl)-；1-(2-methoxyethyl)pyrrolidine-2,5-dione
• CAS: 56058-13-0
• 化学式: C₇H₁₁NO₃
• 分子量: 157.169
• InChiKey: HKVKIPAXYHDYKF-UHFFFAOYSA-N

物化性质

• 沸点：
  295.2±23.0 °C(Predicted)
• 密度：
  1.1764 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,4-丁二醇 、 2-甲氧基乙胺 在 C₂₁H₃₅BrMnN₂O₂P 、 potassium hydride 作用下， 以 甲苯 为溶剂， 反应 40.0h， 以67%的产率得到1-(2-甲氧基乙基)吡咯烷-2,5-二酮
  参考文献：
  名称：

  锰钳配合物催化二醇和胺的无受体脱氢偶联合成环状酰亚胺

  摘要：

  报告了碱金属催化的二醇和胺脱氢偶联形成环状酰亚胺的第一个例子。该反应由地球上丰富的锰的钳形络合物催化，并形成氢气作为唯一的副产品，使整个过程原子经济且环保。

  DOI：

  10.1021/jacs.7b08341

文献信息

• [EN] PHOTOCHROMIC AND ELECTROCHROMIC DIARYLETHENE COMPOUNDS WITH IMPROVED PHOTOSTABILITY AND SOLUBILITY<br/>[FR] COMPOSÉS DIARYLÉTHÈNE PHOTOCHROMIQUES ET ÉLECTROCHROMES PRÉSENTANT UNE PHOTOSTABILITÉ ET UNE SOLUBILITÉ AMÉLIORÉES
  申请人：SWITCH MAT INC

  公开号：WO2020198868A1

  公开（公告）日：2020-10-08

  A diarylethene compound reversibly convertible under photochromic and electrochromic conditions between a ring-open isomer of Formula (1A) and a ring-closed isomer of Formula (IB) wherein R5 is a substituted phenyl ring and Re is a substituted thiophene ring is provided. The photochromic-electrochromic diarylethene compound of Formula (1A)/(1B) have improved photochromic, electrochromic or photochromic and electrochromic properties, and is useful to provide variation of the light transmission properties of optical filters. The compound also possesses improved solubility making it suitable for incorporation in commercial products..

  一种二芳基乙烯化合物，在光致色变和电致色变条件下，在式（1A）的环开异构体和式（1B）的环闭异构体之间可逆转换，其中R5是取代苯环，Re是取代噻吩环。式（1A）/（1B）的光致-电致色变二芳基乙烯化合物具有改进的光致、电致或光致和电致性能，并可用于改变光学滤光片的透光性能。该化合物还具有改进的溶解性，适合用于商业产品中。
• [EN] MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS<br/>[FR] COMPLEXES À BASE DE MANGANÈSE ET LEURS UTILISATIONS SERVANT À UNE CATALYSE HOMOGÈNE
  申请人：YEDA RES & DEV

  公开号：WO2017137984A1

  公开（公告）日：2017-08-17

  The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di- lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

  本发明涉及新型锰配合物及其用途，包括但不限于在以下领域进行均相催化：（1）通过醇和胺的脱氢偶联制备亚胺；（2）使用腈作为迈克尔供体进行迈克尔加成反应中的C-C偶联；（3）将醇脱氢偶联以得到酯和氢气；（4）将酯加氢以形成醇（包括环酯（内酯）或环二酯（二内酯）或聚酯的加氢）；（5）将酰胺（包括环二肽、内酰胺、二酰胺、多肽和聚酰胺）加氢以得到醇和胺（或二胺）；（6）将有机碳酸酯（包括聚碳酸酯）加氢以得到醇或将氨基甲酸酯（包括聚氨基甲酸酯）或脲衍生物加氢以得到醇和胺；（7）将二级醇脱氢以得到酮；（8）酯的酰胺化（即从酯和胺合成酰胺）；（9）使用酯对醇进行酰化；（10）将醇与水和碱偶联以形成羧酸；以及（11）通过氨基醇与水和碱的偶联制备氨基酸或其盐。（12）通过醇和胺的脱氢偶联制备酰胺（包括甲酰胺、环二肽、二酰胺、内酰胺、多肽和聚酰胺）；（13）从二醇制备酰亚胺。
• Fungicidal Azolopyrimidines, Process for Their Preparation and Their Use For Controlling Harmful Fungi, and Also Compositions Comprising Them
  申请人：Dietz Jochen

  公开号：US20100160311A1

  公开（公告）日：2010-06-24

  The present invention relates to azolopyrimidines of the formula I in which the substituents are defined according to the description, to processes and intermediates for preparing these compounds, to compositions comprising them and to their use for controlling phytopathogenic harmful fungi.

  本发明涉及公式I的咪唑嘧啶类化合物，其中取代基根据描述进行定义，涉及制备这些化合物的方法和中间体，包括这些化合物的组合物以及它们用于控制植物病原真菌的用途。
• Hypolipicllemic Activity of Cyclic lmido Alkyl Ethers, Thioethers, Sulfoxides, and Sulfones
  作者：James M. Chapman、Walter J. Sowell、Ghassan Abdalla、Iris H. Hall、Oi T. Wong

  DOI：10.1002/jps.2600781105

  日期：1989.11

  sulfoxides, and sulfones of cyclic imides (e.g., phthalimide, saccharin, 1,8-naphthalimide, succinimide, and 2,3-dihydrophthalazine-1,4-dione) were shown to have potent hypolipidemic activity at doses of 10 and 20 mg/kg/d in rodents. These N-substitutions afforded no improvement over other known N-substitutions (e.g., butyl, 3-butanone, or the propionic acid derivatives of phthalimide, saccharin, and 2,3-

  N-取代的烷基酰亚胺的烷基醚，硫醚，亚砜和砜（例如邻苯二甲酰亚胺，糖精，1,8-萘二甲酰亚胺，琥珀酰亚胺和2,3-二氢邻苯二甲酰-1,4-二酮）具有有效的降血脂活性在啮齿动物中的剂量为10和20 mg / kg / d。与各自的母体相比，这些N-取代与其他已知的N-取代（例如，丁基，3-丁酮或邻苯二甲酰亚胺，糖精和2,3-二氢邻苯二甲酸-1,4-二酮的丙酸衍生物）没有任何改善。化合物。然而，2-（甲氧基乙基）-1H-苯并[de]异喹啉-1,3-（2H）二酮（3a），2- [2-甲基亚磺酰基]乙基-1H-苯并[de]异喹啉-1,3-（与母体化合物相比，2H）二酮（3c），1-（2-甲基亚磺酰基）-2,5-吡咯烷基二酮（4c）和1-（2-甲氧基乙基-2,5-吡咯烷基二酮（4a）显着提高了活性，以及以前报道的N-取代的类似物，可将血清胆固醇水平和甘油三酸酯水平降低40％。16天后，琥珀酰亚胺的硫
• 3-SUBSTITUTED-6-ARYL PYRIDINES
  申请人：Hutchinson Alan J.

  公开号：US20110281837A1

  公开（公告）日：2011-11-17

  3-substituted-6-aryl pyridines of Formula I are provided: wherein R 1 , R 2 , R 3 , R 8 , R 9 , A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3-substituted-6-aryl pyridines, which are useful as probes for the localization of C5a receptors.

  本发明提供了式I的3-取代-6-芳基吡啶化合物：其中R1、R2、R3、R8、R9、A和Ar的定义在此处。这些化合物是C5a受体的配体。式I的优选化合物具有高亲和力结合到C5a受体，并在C5a受体上表现出中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的制药组合物，以及将这些化合物用于治疗各种炎症、心血管和免疫系统疾病的用途。此外，本发明提供了标记的3-取代-6-芳基吡啶，可用作C5a受体定位的探针。