3,3'-dichloro-4,4'-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone | 154023-65-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3'-dichloro-4,4'-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone
• 英文别名: 3,3'-dichloro-4,4'-dimethoxy-5,5'-di(methoxycarbonyl)benzophenone；3,3'-dichloro-4,4'-dimethoxy-5,5'-dimethoxycarbonylbenzophenone；3,3'-dicarbomethoxy-5,5'-dichloro-4,4'-dimethoxybenzophenone；Dimethyl 5,5'-carbonylbis(3-chloro-2-methoxybenzoate)；methyl 3-chloro-5-(3-chloro-4-methoxy-5-methoxycarbonylbenzoyl)-2-methoxybenzoate
• CAS: 154023-65-1
• 化学式: C₁₉H₁₆Cl₂O₇
• 分子量: 427.238
• InChiKey: KYGXJTBNOUDJLM-UHFFFAOYSA-N

物化性质

• 沸点：
  563.2±50.0 °C(Predicted)
• 密度：
  1.355±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3,3'-dichloro-4,4'-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone 在 lithium hydroxide 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 14.0h， 生成 3,3'-dichloro-4,4'-dimethoxy-5,5'-dicarboxybanzophenone
  参考文献：
  名称：

  Heterobifunctional pan-selectin inhibitors

  摘要：

  提供了用于调节体外和体内由选择素结合介导的过程的化合物和方法。更具体地描述了选择素调节剂及其用途，其中调节选择素介导功能的选择素调节剂包括特定的糖类似物，单独或与一类被称为BASAs（苯甲基氨基磺酸）的化合物或一类被称为BACAs（苯甲基氨基羧酸）的化合物中的成员相连。

  公开号：

  US20070054870A1
• 作为产物：
  描述：

  3,3'-dicarbomethoxy-5,5'-dichloro-4,4'-dimethoxydiphenylmethane 在 乙酸酐 、 重铬酸 作用下， 反应 15.0h， 生成 3,3'-dichloro-4,4'-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone
  参考文献：
  名称：

  Heterobifunctional pan-selectin inhibitors

  摘要：

  提供了用于调节体外和体内由选择素结合介导的过程的化合物和方法。更具体地描述了选择素调节剂及其用途，其中调节选择素介导功能的选择素调节剂包括特定的糖类似物，单独或与一类被称为BASAs（苯甲基氨基磺酸）的化合物或一类被称为BACAs（苯甲基氨基羧酸）的化合物中的成员相连。

  公开号：

  US20070054870A1
• 作为试剂：
  描述：

  3,3'-dichloro-4,4'-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone 、 5α-3β-<3'-(triphenylphosphonio)propyl>cholestane bromide 在 sodium hexamethyldisilazane 、 3,3'-dichloro-4,4'-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone 作用下， 生成 1,1-di(3β-cholestanyl)-3-hexene 、 5α-3β-<4',4'-(3",3"'-dicarbomethoxy-5",5"'-dichloro-4",4"'-dimethoxydiphenyl)-3'-butenyl>cholestane
  参考文献：
  名称：

  Design, Synthesis, and Biological Evaluation of Cosalane, a Novel Anti-HIV Agent Which Inhibits Multiple Features of Virus Reproduction

  摘要：

  Cosalane (3), a novel anti-HIV agent having a disalicylmethane unit linked to C-3 of cholestane by a three-carbon Linker, was synthesized from commercially available starting materials by a convergent route. Cosalane proved to be a potent inhibitor of HIV with a broad range of activity against a variety of laboratory, drug-resistant, and clinical HIV-1 isolates, HIV-2, and Rauscher murine leukemia virus. The cytotoxicity of cosalane is relatively low as reflected by an in vitro therapeutic index of > 100. Although cosalane inhibits HIV-1 reverse transcriptase and protease, time of addition experiments indicate that it prevents the cytopathic effect of HIV by acting earlier than reverse transcription in the viral replication cycle. The available evidence indicates that the primary mechanism of action of cosalane involves inhibition of gp120-CD4 binding as well as inhibition of a postattachment event prior to reverse transcription.

  DOI：

  10.1021/jm00045a008

文献信息

• The Biological Effects of Structural Variation at the Meta Position of the Aromatic Rings and at the End of the Alkenyl Chain in the Alkenyldiarylmethane Series of Non-Nucleoside Reverse Transcriptase Inhibitors
  作者：Guozhang Xu、Mark Micklatcher、Maximilian A. Silvestri、Tracy L. Hartman、Jennifer Burrier、Mark C. Osterling、Heather Wargo、Jim A. Turpin、Robert W. Buckheit,、Mark Cushman

  DOI：10.1021/jm010212m

  日期：2001.11.1

  In an effort to elucidate a set of structure-activity relationships in the alkenyldiarylmethane (ADAM) series of non-nucleoside reverse transcriptase inhibitors, a number of modifications were made at two locations: (1) the meta positions of the two aromatic rings and (2) the end of the alkenyl chain. Forty-two new ADAMs were synthesized and evaluated for inhibition of the cytopathic effect of HIV-1(RF)

  为了阐明在烯基二芳基甲烷（ADAM）系列非核苷类逆转录酶抑制剂中的一系列结构活性关系，在两个位置进行了许多修饰：（1）两个芳环的间位和（ 2）烯基链的末端。合成了42种新的ADAM，并评估了它们在CEM-SS细胞培养中对HIV-1（RF）的细胞病变作用的抑制作用以及对HIV-1逆转录酶的抑制作用。发现芳族取代基的大小会影响抗HIV活性，Cl，CH（3）和Br取代基具有最佳活性，而较小（H和F）或较大（I和CF（3）则具有减弱的活性。 ））取代基。还发现烯基链末端的取代基会影响抗病毒活性，具有与甲基或乙基酯基团相关的最大活性，并且由于被高级酯，酰胺，硫化物，亚砜，砜，砜，酯，缩醛，酮，氨基甲酸酯，脲和硫脲取代而导致的活性降低。十二个新的ADAM显示出亚微摩尔EC（50）值，可抑制CEM-SS细胞中HIV-1（RF）的细胞病变作用。将选定的ADAM 19和21与先前发布的ADAM 15和17的
• Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain
  作者：Agustin Casimiro-Garcia、Erik De Clercq、Christophe Pannecouque、Myriam Witvrouw、Tracy L. Stup、Jim A. Turpin、Robert W. Buckheit、Mark Cushman

  DOI：10.1016/s0968-0896(99)00269-2

  日期：2000.1

  Introduction of an amido group or an amino moiety into the alkenyl linker chain of cosalane (1) provided a new series of analogues 3-8. The new compounds were evaluated as inhibitors of the cytopathic effect of HIV-1 and HIV-2 in cell culture. The replacement of the 1' and 2' carbons in the linker chain of I by an amido group was generally tolerated. The length of the linker chain and the stereochemistry

  将氨基或氨基部分引入到al草烷（1）的烯基连接链中提供了一系列新的类似物3-8。新化合物被评估为在细胞培养物中抑制HIV-1和HIV-2的细胞病变作用。通常容许I的连接链中的1'和2'碳被酰胺基取代。连接链的长度和甾族环C-3处取代基的立体化学对抗病毒活性和效价都有重要影响。将氨基部分结合到接头中完全消除了抗HIV活性。在HIV复制周期中有几个步骤被提议作为治疗剂开发的目标（De Clercq，EJ Med。Chem。1995，38，2491; De Clercq，E.Pure Appl.Chem。1998，70， 567）。然而，当前批准的抗HIV药物仅针对病毒酶逆转录酶或蛋白酶（Carpenter。CCJ; MA菲斯切尔; SM汉默; Hirsch女士; DM雅各布森; DA; Katzenstein; JSG Montaner; DD里奇曼;密苏里州萨格（Saag）;密歇根州Scho
• WO2006/127906
  申请人：——

  公开号：——

  公开（公告）日：——
• Golebiewski, W. Marek; Cieniecka-Rosłonkiewicz; Szybinska, Pharmazie, 1999, vol. 54, # 1, p. 26 - 30
  作者：Golebiewski, W. Marek、Cieniecka-Rosłonkiewicz、Szybinska

  DOI：——

  日期：——
• Synthesis of substituted diarylmethylenepiperidines (DAMPs), a novel class of anti-HIV agents
  作者：Guozhang Xu、Arunachalam Kannan、Tracy L Hartman、Heather Wargo、Karen Watson、Jim A Turpin、Robert W Buckheit、Allison A Johnson、Yves Pommier、Mark Cushman

  DOI：10.1016/s0968-0896(02)00095-0

  日期：2002.8

  Substituted diarymethylenepiperidines (DAMPs) were synthesized as conformationally restricted analogues of the alkenyldiarylmethane (ADAM) class of non-nucleoside reverse transcriptase inhibitors (NNRTIs). Although, like the ADAMs, the DAMPs were found to inhibit the cytopathic effect of HIV-1(RF) in CEM-SS cells, they were completely inactive as inhibitors of HIV-1 reverse transcriptase. The DAMPs were assessed for inhibition of HIV attachment and fusion. DAMP 14 was active in both assays with IC50 values of 26.5 muM (TI 3.8) and 12.1 muM (TI: > 8), respectively. DAMP 15 also inhibited HIV fusion with all IC50 12.8 muM (TI: > 6), but not virus attachment. However, attempts to verity inhibition of virus attachment and fusion as antiviral targets using time-of-addition experiments failed to confirm these observations, and instead identified all antiviral target Occurring after completion of reverse transcription. DAMPs 11, 12, 14, and 15 were found to inhibit virus replication if added 8 h post virus exposure, and DAMP 11 was equipotent at inhibition of virus replication if added 24 It after Virus addition. DAMPs 11, 12, and 15 did not inhibit virus replication in TNF-alpha induced latently infected U1 cells, a model for post-integrative antiviral targets. When tested in both 3' end-processing and strand-transfer assays in the presence of HIV-1 integrase. none of the DAMPs showed any inhibitory activity, indicating that HIV-1 integrase is not involved in the mechanism of the antiviral action. Thus, the DAMPs are novel conformationally restricted analogues of the previously published ADAM series with all unidentified antiviral target bounded by the completion of reverse transcription and virus integration. (C) 2002 Elsevier Science Ltd. All rights reserved.