N-cyclopentyl-2-methyl-benzenesulfonamide | 1344994-13-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-cyclopentyl-2-methyl-benzenesulfonamide
• 英文别名: N-cyclopentyl-2-methylbenzenesulfonamide
• CAS: 1344994-13-3
• 化学式: C₁₂H₁₇NO₂S
• 分子量: 239.338
• InChiKey: IJLCTYJWALYOCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻,对甲苯磺酰胺 、 环戊烯 在 silica gel supported triflic acid 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以88%的产率得到N-cyclopentyl-2-methyl-benzenesulfonamide
  参考文献：
  名称：

  The hydroamination of alkenes with sulfonamides catalyzed by the recyclable silica gel supported triflic acid

  摘要：

  The vast applications of triflic acid (TfOH) in catalysis are severely limited by its corrosive and fuming properties. Immobilization of TfOH on silica gel well solves these problems and affords efficient recovery and reusability of TfOH. Two types of supported TfOH, the prepared silica gel supported TfOH and the in situ silica gel adsorbed TfOH, both exhibit good catalytic activity and reusability in the hydroamination of alkene with sulfonamide. The in situ silica gel adsorbed catalyst has been used for 5 runs with maintained reactivities and yields, which are superior to the performance of the prepared silica gel supported TfOH. For a series of alkenes and various sulfonamides, the heterogeneous hydroamination reactions catalyzed by both types of silica gel supported TfOH to afford similar moderate to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.025

文献信息

• The hydroamination of alkenes with sulfonamides catalyzed by the recyclable silica gel supported triflic acid
  作者：Pei Nian Liu、Fei Xia、Zheng Le Zhao、Qing Wei Wang、Yu Jie Ren

  DOI：10.1016/j.tetlet.2011.09.025

  日期：2011.11

  The vast applications of triflic acid (TfOH) in catalysis are severely limited by its corrosive and fuming properties. Immobilization of TfOH on silica gel well solves these problems and affords efficient recovery and reusability of TfOH. Two types of supported TfOH, the prepared silica gel supported TfOH and the in situ silica gel adsorbed TfOH, both exhibit good catalytic activity and reusability in the hydroamination of alkene with sulfonamide. The in situ silica gel adsorbed catalyst has been used for 5 runs with maintained reactivities and yields, which are superior to the performance of the prepared silica gel supported TfOH. For a series of alkenes and various sulfonamides, the heterogeneous hydroamination reactions catalyzed by both types of silica gel supported TfOH to afford similar moderate to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.