4-nitrophenylcarbamic acid cyclohexyl ester | 23294-39-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitrophenylcarbamic acid cyclohexyl ester
• 英文别名: Cyclohexyl N-(p-nitrophenyl)carbamate；Aniline, N-cyclohexyloxycarbonyl-4-nitro-；cyclohexyl N-(4-nitrophenyl)carbamate
• CAS: 23294-39-5
• 化学式: C₁₃H₁₆N₂O₄
• 分子量: 264.281
• InChiKey: MFDKGZMZEIOPIT-UHFFFAOYSA-N

物化性质

• 熔点：
  115.2-116.4 °C
• 沸点：
  372.7±25.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯基氨基甲酸环己酯 在 HSO₃ONO 、 硝酸 作用下， 以 溶剂黄146 为溶剂， 反应 1.5h， 生成 4-nitrophenylcarbamic acid cyclohexyl ester
  参考文献：
  名称：

  Velikorodov, Russian Journal of Organic Chemistry, 2000, vol. 36, # 2, p. 233 - 239

  摘要：

  DOI：

文献信息

• PRODUCTION METHOD OF CARBAMIC ACID ESTER
  申请人：NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：US20190185420A1

  公开（公告）日：2019-06-20

  A method of production of carbamic acid ester has a high yield and high selectivity and is superior in economy. The method of production of a carbamic acid ester includes reacting an amine, carbon dioxide, and an alkoxysilane compound in the presence of a catalyst containing a zinc compound or an alkali metal compound or in the presence of an ionic liquid. A carbamic acid ester is produced, for example by reacting aniline, carbon dioxide, and tetramethoxysilane at a temperature of 150 to 180° C. in the presence of zinc acetate and 2,2′-bipyridine.

  一种生产氨基甲酸酯的方法具有高产率和高选择性，并在经济上优越。生产氨基甲酸酯的方法包括在催化剂的存在下，将胺、二氧化碳和烷氧基硅烷化合物反应，所述催化剂含有锌化合物或碱金属化合物或存在于离子液体中。例如，通过在150至180°C的温度下，在锌醋酸和2,2'-联吡啶的存在下，将苯胺、二氧化碳和四甲氧基硅烷反应，可以生产氨基甲酸酯。
• METHOD FOR PRODUCING CARBAMIC ACID ESTER
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP3508473A1

  公开（公告）日：2019-07-10

  A method of production of carbamic acid ester has a high yield and high selectivity and is superior in economy. The method of production of a carbamic acid ester includes reacting an amine, carbon dioxide, and an alkoxysilane compound in the presence of a catalyst containing a zinc compound or an alkali metal compound or in the presence of an ionic liquid. A carbamic acid ester is produced, for example by reacting aniline, carbon dioxide, and tetramethoxysilane at a temperature of 150 to 180°C in the presence of zinc acetate and 2,2'-bipyridine.

  一种生产氨基甲酸酯的方法具有高产率和高选择性，而且经济性更好。氨基甲酸酯的生产方法包括在含有锌化合物或碱金属化合物的催化剂存在下，或在离子液体存在下，使胺、二氧化碳和烷氧基硅烷化合物发生反应。例如，在乙酸锌和 2,2'-联吡啶的存在下，苯胺、二氧化碳和四甲氧基硅烷在 150 至 180°C 的温度下发生反应，即可制得氨基甲酸酯。
• Production method of carbamic acid ester
  申请人：NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：US10752579B2

  公开（公告）日：2020-08-25

  A method of production of carbamic acid ester has a high yield and high selectivity and is superior in economy. The method of production of a carbamic acid ester includes reacting an amine, carbon dioxide, and an alkoxysilane compound in the presence of a catalyst containing a zinc compound or an alkali metal compound or in the presence of an ionic liquid. A carbamic acid ester is produced, for example by reacting aniline, carbon dioxide, and tetramethoxysilane at a temperature of 150 to 180° C. in the presence of zinc acetate and 2,2′-bipyridine.

  一种生产氨基甲酸酯的方法具有高产率和高选择性，而且经济性更好。氨基甲酸酯的生产方法包括在含有锌化合物或碱金属化合物的催化剂存在下，或在离子液体存在下，使胺、二氧化碳和烷氧基硅烷化合物发生反应。例如，在乙酸锌和 2,2′-联吡啶的存在下，苯胺、二氧化碳和四甲氧基硅烷在 150 至 180 摄氏度的温度下反应，可制得氨基甲酸酯。
• The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors
  作者：Anna Minkkilä、Mikko J. Myllymäki、Susanna M. Saario、Joel A. Castillo-Melendez、Ari M.P. Koskinen、Christopher J. Fowler、Jukka Leppänen、Tapio Nevalainen

  DOI：10.1016/j.ejmech.2009.01.007

  日期：2009.7

  A series of para-substituted phenolic N-alkyl carbamates were evaluated for their FAAH and MGL inhibitory activities. The compounds were generally selective for FAAH, with IC50 values in the nM range, whereas inhibition of MGL required concentrations three orders of magnitude higher. The most potent compounds, dodecylcarbamic acid 4-(4,5-dihydrothiazol-2-yl)phenyl (12) and 4-(1,2,3-thiadiazol-4-yl)phenyl (26) esters, inhibited FAAH and MGL with IC50 values at the low-nanomolar (IC(50)s: 0.0063 and 0.012 mu M) and the low-micromolar ranges (IC(50)s; 2.1 and 1.0 mu M), respectively. Compound 26 also inhibited both FAAH-dependent AEA uptake and AEA hydrolysis (IC50; 0.082 mu M) by intact RBL2H3 cells, and could also reduce 2-AG hydrolysis by these cells at concentrations >= 0.030 mu M. (C) 2009 Elsevier Masson SAS. All rights reserved.
• A New and Facile Synthesis of Alkyl<i>N</i>-Arylcarbamates
  作者：Rino Leardini、Giuseppe Zanardi

  DOI：10.1055/s-1982-29757

  日期：——