2-[(2-hydroxyethyl)(methyl)-amino]-1,1-diphenylethanol | 134201-26-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2-hydroxyethyl)(methyl)-amino]-1,1-diphenylethanol
• 英文别名: 2-[(2-hydroxyethyl)(methyl)amino]-1,1-diphenylethanol；MeN(CH2CPh2OH)(CH2CH2OH)；(2-hydroxy-ethyl)-(2-hydroxy-2,2-diphenyl-ethyl)-methyl-amine；(2-Hydroxy-aethyl)-(2-hydroxy-2,2-diphenyl-aethyl)-methyl-amin；2-[2-hydroxyethyl(methyl)amino]-1,1-diphenylethanol
• CAS: 134201-26-6
• 化学式: C₁₇H₂₁NO₂
• 分子量: 271.359
• InChiKey: OHILFHVQPQXKLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[(2-hydroxyethyl)(methyl)-amino]-1,1-diphenylethanol 在 硫酸 作用下， 生成 4-methyl-2,2-diphenyl-morpholine
  参考文献：
  名称：

  Some 2-Substituted-4-methylmorpholines

  摘要：

  DOI：

  10.1021/ja01152a522
• 作为产物：
  描述：

  N-甲基-2-羟基乙胺 、 1,1-二苯基环氧乙烷 反应 35.0h， 以77%的产率得到2-[(2-hydroxyethyl)(methyl)-amino]-1,1-diphenylethanol
  参考文献：
  名称：

  二链烷醇胺配体的钛配合物：合成与结构

  摘要：

  标题化合物的合成，即。[RN(CH 2 CH 2 O)-(CHR 1 CR 2 R 3 O)]Ti(OiPr) 2 (13-15) 和[RN(CH 2 CH 2 O)-(CHR 1 CR 2 R 3 O) ] 2 Ti (18-28)，通过一或两当量的相应二烷醇胺 RN(CH 2 CH 2 OH)(CHR 1 CR 2 R 3 OH) (1-12) 与 Ti(OiPr) 4 的反应是报道。[RN(CH 2 CH 2 O)(CHR 1 CR 2 R 3 O)] 2 Ti的其他途径，例如Ti(CH 2 Ph) 4 与二烷醇胺的反应以及TiCl 4 (THF) 2 与还测试了二烷醇胺/Et 3 N。二聚钛烷16，[PhCH 2 N(CH 2 CH 2 O) 2 Ti-(OMe) 2 ] 2 ，由一当量二烷醇胺3与CpTi(OMe) 3 ，PhCH 2 N(CH 2 CH)反应获得2 O) 2 -Ti(OMenth)

  DOI：

  10.1002/ejic.200501154

文献信息

• Palladium complexes with stabilized germylene and stannylene ligands
  作者：Marina M. Kireenko、Kirill V. Zaitsev、Yuri F. Oprunenko、Andrei V. Churakov、Viktor A. Tafeenko、Sergey S. Karlov、Galina S. Zaitseva

  DOI：10.1039/c3dt32867h

  日期：——

  The syntheses of novel Pd complexes with germylene and stannylene ligands are reported. [MeN(CH2CH2NC6F5)2Sn]4Pd (2) and [MeN(CH2CPh2O)(CH2CH2O)Ge]4Pd (8) were obtained by different methods including ligand substitution in (Ph3P)4Pd or by the reaction of the free corresponding germylene or stannylene with (Ph3P)2PdCl2 or Pd(OAc)2. Crystal structures of complexes 2, 8 were determined by single crystal

  报道了具有亚二甲基和亚锡烷基配体的新型Pd配合物的合成。[MeN（CH 2 CH 2 NC 6 F 5）2 Sn] 4 Pd（2）和[MeN（CH 2 CPh 2 O）（CH 2 CH 2 O）Ge] 4 Pd（8）是通过不同的方法获得的，包括（Ph 3 P）4 Pd中的配体取代或通过游离的相应的亚二甲基或亚苯乙烯与（Ph 3 P）2 PdCl 2或Pd（OAc）2的反应。复合物的晶体结构2，8是由单晶X射线衍射分析来确定。配合物的催化活性的2，8在铃木-宫浦检查和的Heck交叉耦合。
• Stabilized germylenes based on dialkanolamines: Synthesis, structure, chemical properties
  作者：Mengmeng Huang、Marina M. Kireenko、Kirill V. Zaitsev、Yuri F. Oprunenko、Andrei V. Churakov、Judith A.K. Howard、Maxim V. Zabalov、Elmira Kh. Lermontova、Jörg Sundermeyer、Thomas Linder、Sergey S. Karlov、Galina S. Zaitseva

  DOI：10.1016/j.jorganchem.2012.01.018

  日期：2012.6

  dimeric in the solid state due to the formation of intermolecular Ge–O bonds, the complex 10 is monomeric, all compounds possess a transannular Ge–N bond. The reactivity of the germylenes synthesized was investigated in reactions of oxidative insertion (with halogenation reagents, MeI, disulfides), [1 + 4]-cycloaddition, oxidation and in reactions with water and acetic anhydride. Some reactions were investigated

  一系列新型的低的价锗化合物RN（CHR 2 CR 1 - [R 3 O）（CHR 4 CHR 5 O）的Ge 1 - 13（- [R  = Me中，pH值，BN; [R 1，- [R 2，- [R 3，- [R 4，通过Ge [N（SiMe 3）2 ]之间的反应获得R 5  ＝ H，Me，Ph，（CH 2）3，（CH 2）4，CH 2（C 6 H 4））。2和各种二链烷醇胺。通过元素分析，所有新化合物进行了表征1个H和13 C NMR光谱和在一些情况下通过X射线衍射分析（1，3，8，10）。化合物1，3，8是在固体状态二聚体由于分子间的Ge-O键的形成，该复合物10由于是单体，所有化合物均具有跨环的Ge–N键。在氧化插入（与卤化试剂，MeI，二硫化物），[1 + 4]-环加成，氧化以及与水和乙酸酐的反应中，研究了合成的亚甲基苯的反应性。通过DFT计算研究了一些反应。
• Synthesis and structures of new 1,3,6,2-dioxazaborocanes containing substituents in the ocane fragment
  作者：E. Kh. Lermontova、M. M. Huang、S. S. Karlov、M. V. Zabalov、A. V. Churakov、B. Neumüller、G. S. Zaitseva

  DOI：10.1007/s11172-008-0259-5

  日期：2008.9

  exemplified by the reaction of compound 6. The structures of erythro-MeN(CH2CH2O)(CHPhCHPhO)BPh (3), threo-MeN(CH2CH2O)(CHPhCHPhO)BPh (4), erythro-MeN(CH2CH2O)(CHPhCHPhO)B(4-MeC6H4) (8), and PhCH2N(CH2CH2O)2BF (13) were established by X-ray diffraction. The coordination polyhedra of the boron atoms in these complexes can be described as distorted tetrahedra. The boron-nitrogen distances (1.705(7)–1.723(3)

  新的 1,3,6,2-二氧杂硼烷 R1N(CHR3CR4R2O)(CHR6CHR5O)BX (1–11, X = Ph, 4-MeC6H4, Me; R1 = Me, Ph ; R2, R3, R4, R5, R6 = H , Ph) 是通过芳基或甲基硼酸与二链烷醇胺的反应合成的。(Me2N O)3B (15) 用 MeN( OH)(CH2CPh2OH) 处理得到 2-[2-(二甲-乙氨基) 乙氧基]-1,3,6,2-二氧杂硼烷 (12)。合成了 2-氟-1,3,6,2-二氧杂硼烷 R1N(CHR3CHR2O)( O)BF (13: R1 = Ph , R2 = R3 = H; 14: R1 = Me, R2 = R3 = Ph, threo)通过相应二烷醇胺的双（三甲基甲硅烷基）醚与 BF3·Et2O 反应。新的硼烷可用于合成相应的锗衍生物 Ph N( O)2GeX2
• The transannular interaction germanium–nitrogen in germocanes: The influence of substituents
  作者：Elmira Kh. Lermontova、Anastasia A. Selina、Sergey S. Karlov、Andrei V. Churakov、Judith A.K. Howard、Yuri F. Oprunenko、Mikhail Yu. Antipin、Jörg Sundermeyer、Galina S. Zaitseva

  DOI：10.1016/j.jorganchem.2006.08.011

  日期：2006.12

  The reaction of RN(CH2CH2OH)(CHRCRROH)-C-1-R-2-O-3 (1-8) with a stoichiometric amount of tetrachloro(bromo)germane leads to the corresponding RN(CH2CH2O)((CHRCRRO)-C-1-R-2-O-3)GeHal(2) (9-21). Difluorenylgermocane 22 was prepared by treatment of diethoxydifluorenylgermane with N-methyldiethanolamine. Different dialkanolamines were found to be successive precursors of dimethylgermocanes, RN(CH2CH2O)((CHRCRRO)-C-1-R-2-O-3)GeMe2 (23-26). The chemical properties of simple and easy to access germocanes RN(CH2CH2O)(2)GeX2 [X=OH, Br (28), Cl (29)] were studied and the difluoro (27), haloalkoxy (30-32), and dialkoxy (33, 34) derivatives were prepared. The structures of the compounds 16, 20-22, and 26 were confirmed by X-ray diffraction and the structural features in solution of 23 and 26 were studied by NMR spectroscopy (NOES). The relationship between the nature of substituents at different positions of the germocane skeleton and the strength of the intramolecular Ge <- N bond is discussed. (c) 2006 Elsevier B.V. All rights reserved.
• 4-Methyl-2,2-diarylmorpholines
  作者：T. A. Geissman、Murray Bassin、Ernest J. Zeilberger

  DOI：10.1021/ja01156a517

  日期：1951.12