Bromdiphenylessigsaeure-ethylester | 57225-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bromdiphenylessigsaeure-ethylester
• 英文别名: bromo-diphenyl-acetic acid ethyl ester；Brom-diphenyl-essigsaeure-aethylester；Ethyl 2-bromo-2,2-diphenylacetate
• CAS: 57225-94-2
• 化学式: C₁₆H₁₅BrO₂
• 分子量: 319.198
• InChiKey: WSHKKOXMIQVCRM-UHFFFAOYSA-N

物化性质

• 沸点：
  375.3±37.0 °C(Predicted)
• 密度：
  1.353±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Bromdiphenylessigsaeure-ethylester 在 盐酸 、 铜 作用下， 以 氯仿 、 苯 为溶剂， 反应 8.0h， 生成 <4-<(Ethoxycarbonyl)phenylmethyl>phenyl>diphenylessigsaeure-ethylester
  参考文献：
  名称：

  Neumann, Wilhelm P.; Stapel, Ralf, Chemische Berichte, 1986, vol. 119, # 11, p. 3422 - 3431

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴-2,2-二苯基乙酸 在 氢溴酸 作用下， 生成 Bromdiphenylessigsaeure-ethylester
  参考文献：
  名称：

  Salkind; Peschekerowa, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1914, vol. 46, p. 486

  摘要：

  DOI：

文献信息

• Process for the preparation of copolymers of ethylene with at least one other 1-alkene
  申请人：STAMICARBON B.V.

  公开号：EP0044119A2

  公开（公告）日：1982-01-20

  Process for the preparation of copolymers consisting of 25-85% by wt. of ethylene, 15-75% by wt. of at least one other 1-alkene and optionally up to 20% by wt. of a polyunsaturated compound with application of a catalyst system containing a compound of a metal from sub-groups IV-VI of the periodic system and a compound of a metal from groups I-III of the periodic system, in which at least one hydrocarbon group is bound directly to the metal atom via a carbon atom, the polymerization being carried out in the presence of a halogen-containing compound of the general formula where A is a phenyl group which may contain one or two substituent halogen atoms or alkyl groups, or is a thienyl, furyl, pyrollyl, N-alkylpyrollyl or pyridyl group, which group is bound to the carbon atom directly or via a carbonyl group, X is a chlorine or bromine atom, Y is a chlorine, bromine or hydrogen atom or a hydrocarbon group with 1-8 carbon atoms, and Z is a nitrile group, a carboxyl group, an ester group, a hydrocarbyloxyalkylcarboxyl group, an carboxylic acid halide group, an amide group, a benzoyl group, a carboxyphenyl group or a carboxylhydrocarbylphenyl group.

  制备由 25-85%（重量百分比）乙烯、15-75%（重量百分比）至少一种其他 1-烯烃和（任选）最多 20%（重量百分比）多不饱和化合物组成的共聚物的工艺，其中催化剂体系含有周期系第Ⅳ-Ⅵ亚族金属化合物和周期系第Ⅰ-Ⅲ族金属化合物。聚合反应是在通式如下的含卤素化合物存在下进行的 其中 A 是苯基，可含有一个或两个取代卤素原子或烷基，或者是噻吩基、呋喃基、吡咯基、 N-烷基吡咯基或吡啶基，该基团直接或通过羰基与碳原子结合；X 是氯原子或溴原子；Y 是氯、Z 为腈基、羧基、酯基、烃基羧基、羧酸卤化基、酰胺基、苯甲酰基、羧基苯基或羧基氢羧基苯基。
• Rhodanine derivatives, a process for their preparation, and aldose reductase inhibitors containing such derivatives
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0045165A1

  公开（公告）日：1982-02-03

  Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing such derivatives. A rhodanine derivative of the general formula: is disclosed wherein R' represents a hydrogen atom, an alkyl group of 1-12 carbon atoms, an aralkyl group of 7-13 carbon atoms, a cycloalkyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, or a phenyl group which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms, or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms; R2 and R3, which may be the same or different, each represents a hydrogen atom, an alkyl group of 1-4 carbon atoms, or a phenyl group which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms, or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms; R4 represents an alkyl group of 1-4 carbon atoms, a cycloalkyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, a phenyl or benzyl group which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms, or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms, a naphthyl group, an anthracenyl group, or a heterocyclic group containing at least one of nitrogen, oxygen and sulfur atoms which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms; or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms; R5 represents a hydrogen atom, an alkyl group of 1-4 carbon atoms, a cycloalkyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, a phenyl or benzyl group which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms, or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms, a naphthyl group, an anthracenyl group, or a heterocyclic group containing at least one of nitrogen, oxygen and sulfur atoms which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms, or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms, with the proviso that when R5 represents a hydrogen atom, R4 does not represent an alkyl group of 1-4 carbon atoms; n is 0, 1 or 2; or when R' represents a hydrogen atom, a non-toxic salt of the acid. The derivatives of formula I and their non-toxic acid salts possess a strong inhibitory activity on aldose reductase, and are useful for the prevention and treatment of nerve disturbances such as neuralgia, retinopathy, diabetic cataract and renal disturbances such as tubular nephropathy.

  罗丹宁衍生物、其制备工艺以及含有此类衍生物的醛糖还原酶抑制剂。本发明公开了一种通式如下的罗丹宁衍生物： 其中 R'代表氢原子、1-12 个碳原子的烷基、7-13 个碳原子的芳烷基、未被取代或被至少一个 1-4 个碳原子的烷基取代的 4-7 个碳原子的环烷基、或未被取代或被至少一个卤原子、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基或 1-4 个碳原子的烷基、烷氧基或烷硫基取代的苯基；R2 和 R3（可以相同或不同）分别代表氢原子、1-4 个碳原子的烷基或未被取代或被至少一个卤素原子、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基或 1-4 个碳原子的烷基、烷氧基或烷硫基取代的苯基；R4 代表 1-4 个碳原子的烷基、未被取代或被至少一个 1-4 个碳原子的烷基取代的 4-7 个碳原子的环烷基、未被取代或被至少一个卤原子取代的苯基或苄基、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基取代的氨基、或 1-4 个碳原子的烷基、烷氧基或烷硫基、萘基、蒽基、或含有至少一个氮、氧和硫原子的杂环基团，该杂环基团未被取代或被至少一个卤素原子、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基取代的氨基取代；或 1-4 个碳原子的烷基、烷氧基或烷硫基；R5 代表氢原子、1-4 个碳原子的烷基、未被取代或被至少一个 1-4 个碳原子的烷基取代的 4-7 个碳原子的环烷基、未被取代或被至少一个卤素原子取代的苯基或苄基、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基或 1-4 个碳原子的烷基、烷氧基或烷硫基取代的氨基、萘基、蒽基，或含有至少一个氮、氧和硫原子的杂环基团，该杂环基团未被取代或被至少一个卤素原子、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基或 1-4 个碳原子的烷基、烷氧基或烷硫基取代，但当 R5 代表氢原子时，R4 不代表 1-4 个碳原子的烷基；n 为 0、1 或 2；或当 R' 代表氢原子时，为该酸的无毒盐。 式 I 的衍生物及其无毒酸盐对醛糖还原酶具有很强的抑制活性，可用于预防和治疗神经紊乱，如神经痛、视网膜病变、糖尿病性白内障和肾功能紊乱，如肾小管肾病。
• Process for producing copolymer
  申请人：Kawashima Jun

  公开号：US20050014914A1

  公开（公告）日：2005-01-20

  There are provided (I) a process for producing a copolymer of ethylene, an α-olefin having from 3 to 20 carbon atoms and optionally a polyene, which comprises the step of copolymerizing those monomers in a polymerization reactor by feeding the following components (A), (B), (C1) and (D) to the polymerization reactor: (A) a transition metal complex, (B) an organic aluminum compound, (C1) a halogen-containing compound, and (D) a Lewis base, wherein those components are fed to the polymerization reactor without a preliminary contact of (1) the component (A) with the component (B), (2) the component (A) with the component (C1), (3) the component (B) with the component (C1), and (4) the component (B) with the component (D); and (II) a process for producing said copolymer, which comprises the step of copolymerizing those monomers in a polymerization reactor (i) by feeding to the polymerization reactor the components (A), (B), (D), (C2) a halogen-containing compound, which is a derivative of an aryl group-containing carboxylic acid, and (C3) a halogen-containing compound, which is not a derivative of a carboxylic acid, or (ii) by feeding thereto the components (A), (B), (D), (C3), and (C4) a halogen-containing compound, which is a derivative of a carboxylic acid containing an unsaturated bond-carrying linear organic group.

  提供了(I)一种生产乙烯、具有 3 至 20 个碳原子的α-烯烃和任选的一种聚烯的共聚物的工艺，该工艺包括在聚合反应器中通过向聚合反应器加入下列组分(A)、(B)、(C1)和(D)使这些单体共聚的步骤：(A)过渡金属络合物，(B)有机铝化合物，(C1)含卤素化合物，和(D)路易斯碱，其中这些组分在送入聚合反应器时不需要(1)组分(A)与组分(B)，(2)组分(A)与组分(C1)，(3)组分(B)与组分(C1)，和(4)组分(B)与组分(D)的初步接触；和(II) 生产所述共聚物的工艺，该工艺包括在聚合反应器(i)中通过向聚合反应器加入组分(A)、(B)、(D)、(C2)含卤素化合物（含芳基羧酸的衍生物）来共聚这些单体的步骤、和 (C3) 含卤化合物，它不是羧酸的衍生物，或 (ii) 向反应器中加入组分 (A)、(B)、(D)、(C3) 和 (C4) 含卤化合物，它是含有不饱和键载线性有机基团的羧酸的衍生物。
• US2387447
  申请人：——

  公开号：——

  公开（公告）日：——
• NEUMANN W. P.; STAPEL R., CHEM. BER., 119,(1986) N 11, 3422-3431
  作者：NEUMANN W. P.、 STAPEL R.

  DOI：——

  日期：——