7,11-dimethylene-6,7,8,9-tetrahydro-5,9-propano-5H-benzocycloheptene | 73947-11-2

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 7,11-dimethylene-6,7,8,9-tetrahydro-5,9-propano-5H-benzocycloheptene
• 英文别名: 7,11-dimethylene-6,7,8,9-tetrahydro-5,9-propano-5H-benzocyloheptene；5,9-Propano-5H-benzocycloheptene, 6,7,8,9-tetrahydro-7,11-bis(methylene)-；10,13-dimethylidenetricyclo[6.3.3.02,7]tetradeca-2,4,6-triene
• CAS: 73947-11-2
• 化学式: C₁₆H₁₈
• 分子量: 210.319
• InChiKey: SDNJCJAPTDBOFQ-UHFFFAOYSA-N

物化性质

• 沸点：
  276.0±40.0 °C(Predicted)
• 密度：
  1.01±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  7,11-dimethylene-6,7,8,9-tetrahydro-5,9-propano-5H-benzocycloheptene 在 硫酸 、 sodium cyanoborohydride 、 溶剂黄146 、 硫脲 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 36.0h， 生成 N-benzyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride
  参考文献：
  名称：

  Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities

  摘要：

  The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.11.050
• 作为产物：
  描述：

  9,10-Benzo-bicyclo[3.3.2]dec-9-en-3,7-dion 、 亚甲基三苯基膦烷 、 二甲基硫 以63%的产率得到
  参考文献：
  名称：

  BISHOP, R.;BISHOP, A., AUSTRAL. J. CHEM., 1983, 36, N 12, 2465-2472

  摘要：

  DOI：

文献信息

• Amini; Bishop, Roger; Burgess, Graham, Australian Journal of Chemistry, 1989, vol. 42, # 11, p. 1919 - 1928
  作者：Amini、Bishop, Roger、Burgess, Graham、Craig, Donald C.、Dance, Ian G.、Scudder, Marcia L.

  DOI：——

  日期：——
• Ritter reactions. II. Reductive deamidation of N-bridgehead amides.
  作者：Roger Bishop、Graham Burgess

  DOI：10.1016/s0040-4039(01)81048-0

  日期：1987.1
• Amini; Bishop, Roger, Australian Journal of Chemistry, 1983, vol. 36, # 12, p. 2465 - 2472
  作者：Amini、Bishop, Roger

  DOI：——

  日期：——
• AMINI;BISHOP, ROGER;BURGESS, GRAHAM;CRAIG, DONALD C.;DANCE, IAN G.;SCUDDE+, AUSTRAL. J. CHEM., 42,(1989) N1, C. 1919-1928
  作者：AMINI、BISHOP, ROGER、BURGESS, GRAHAM、CRAIG, DONALD C.、DANCE, IAN G.、SCUDDE+

  DOI：——

  日期：——
• Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities
  作者：Eva Torres、María D. Duque、Marta López-Querol、Martin C. Taylor、Lieve Naesens、Chunlong Ma、Lawrence H. Pinto、Francesc X. Sureda、John M. Kelly、Santiago Vázquez

  DOI：10.1016/j.bmc.2011.11.050

  日期：2012.1

  The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein. (C) 2011 Elsevier Ltd. All rights reserved.