3,4,5-trimethoxy-N-(3-nitrobiphenyl-4-yl)benzamide | 1352637-78-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4,5-trimethoxy-N-(3-nitrobiphenyl-4-yl)benzamide
• 英文别名: 3,4,5-trimethoxy-N-(2-nitro-4-phenylphenyl)benzamide
• CAS: 1352637-78-5
• 化学式: C₂₂H₂₀N₂O₆
• 分子量: 408.411
• InChiKey: FZTFYRFVODKCGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,4,5-trimethoxy-N-(3-nitrobiphenyl-4-yl)benzamide 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以50%的产率得到3,4-dihydroxy-5-methoxy-N-(3-nitrobiphenyl-4-yl)benzamide
  参考文献：
  名称：

  Potent Galloyl-Based Selective Modulators Targeting Multidrug Resistance Associated Protein 1 and P-glycoprotein

  摘要：

  The multifactorial nature of chemotherapy failure in controlling cancer is often associated with the occurrence of multidrug resistance (MDR), a phenomenon likely related to the increased expression of members of the ATP binding cassette (ABC) transporter superfamily. In this respect, the most extensively characterized MDR transporters include ABCB1 (also known as MDR1 or P-glycoprotein) and ABCC1 (also known as MRP1) whose inhibition remains a priority to circumvent drug resistance. Herein, we report how the simple galloyl benzamide scaffold can be easily and properly decorated for the preparation of either MRP1 or P-gp highly selective inhibitors. In particular, some gallamides and pyrogallol-l-monomethyl ethers showed remarkable affinity and selectivity toward MRP1. On the other hand, trimethyl ether galloyl anilides, with few exceptions, exhibited moderate to very high and selective P-gp inhibition.

  DOI：

  10.1021/jm201305y
• 作为产物：
  描述：

  4-溴-2-硝基苯胺 在 四(三苯基膦)钯 、 potassium carbonate 、 N,N-二甲基甲酰胺 作用下， 以 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.42h， 生成 3,4,5-trimethoxy-N-(3-nitrobiphenyl-4-yl)benzamide
  参考文献：
  名称：

  Potent Galloyl-Based Selective Modulators Targeting Multidrug Resistance Associated Protein 1 and P-glycoprotein

  摘要：

  The multifactorial nature of chemotherapy failure in controlling cancer is often associated with the occurrence of multidrug resistance (MDR), a phenomenon likely related to the increased expression of members of the ATP binding cassette (ABC) transporter superfamily. In this respect, the most extensively characterized MDR transporters include ABCB1 (also known as MDR1 or P-glycoprotein) and ABCC1 (also known as MRP1) whose inhibition remains a priority to circumvent drug resistance. Herein, we report how the simple galloyl benzamide scaffold can be easily and properly decorated for the preparation of either MRP1 or P-gp highly selective inhibitors. In particular, some gallamides and pyrogallol-l-monomethyl ethers showed remarkable affinity and selectivity toward MRP1. On the other hand, trimethyl ether galloyl anilides, with few exceptions, exhibited moderate to very high and selective P-gp inhibition.

  DOI：

  10.1021/jm201305y

文献信息

• GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS
  申请人：Universita' Degli Studi di Bari

  公开号：EP2986286A1

  公开（公告）日：2016-02-24
• [EN] GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS<br/>[FR] COMPOSÉS À BASE DE GALLOYL BENZAMIDE UTILISÉS EN TANT QUE MODULATEURS DE JNK
  申请人：UNIVERSIT DEGLI STUDI DI BARI

  公开号：WO2014170706A1

  公开（公告）日：2014-10-23

  The present invention relates to the use of compounds having a galloyl benzamide structure in the treatment and/or prevention of medical conditions mediated through c-Jun N-terminal kinases (JNKs) and to pharmaceutical compositions comprising said compounds.