2,4-dichlorobenzyl (pyridin-3-yl)-ketone | 84901-56-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dichlorobenzyl (pyridin-3-yl)-ketone
• 英文别名: 2-(2,4-dichlorophenyl)-1-(3-pyridinyl)-ethanone；2,4-dichlorobenzyl pyridin-3-yl ketone；2,4-dichlorobenzyl (3-pyridyl) ketone；2,4-dichlorobenzyl 3-pyridyl ketone；2-(2,4-dichlorophenyl)-1-pyridin-3-ylethanone
• CAS: 84901-56-4
• 化学式: C₁₃H₉Cl₂NO
• 分子量: 266.127
• InChiKey: PIODTJOXJJOIIK-UHFFFAOYSA-N

物化性质

• 沸点：
  408.0±35.0 °C(Predicted)
• 密度：
  1.338±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,4-dichlorobenzyl (pyridin-3-yl)-ketone 生成 sodium;2-[(Z)-2-(2,4-dichlorophenyl)-1-pyridin-3-ylethenoxy]propanoate
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二氯苯乙腈 在 硫酸 、 氨 、 sodium 、 溶剂黄146 作用下， 以 烟酸乙酯 、 乙醇 为溶剂， 生成 2,4-dichlorobenzyl (pyridin-3-yl)-ketone
  参考文献：
  名称：

  1,3-Dioxolane compounds and their use as fungicides

  摘要：

  本发明公开了式子 ##STR1## 中R为氢或C.sub.1-4烷基的1,3-二氧杂环己烷衍生物及其酸加成盐，以及它们的制备方法，包含这些化合物作为活性成分的杀真菌组合物，以及使用这些化合物或组合物在农业和园艺中对抗真菌的方法。

  公开号：

  US04380544A1

文献信息

• GLUCOCORTICOID RECEPTOR ANTAGONISTS
  申请人：Bailly Jacques

  公开号：US20090088425A1

  公开（公告）日：2009-04-02

  The present invention relates to compounds of formula I wherein A, n, R 1a to R 1e and R 2 to R 5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

  本发明涉及以下式I的化合物 其中A，n，R1a至R1e和R2至R5如描述和权利要求中所定义，并且其药学上可接受的盐。这些化合物是糖皮质激素受体拮抗剂，可用于治疗和/或预防疾病，如糖尿病，血脂异常，肥胖，高血压，心血管疾病，肾上腺失调或抑郁症。
• Certain 2,4-dichloro-phenyl(loweralkylidene) pyridines having fungicidal
  申请人：Ciba-Geigy Corporation

  公开号：US05036074A1

  公开（公告）日：1991-07-30

  The invention concerns new pyridine derivatives of the formula ##STR1## wherein X signifies a group ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the significances given in the description, and their N-oxides, N-amino salts, copper complexes and acid addition salts, processes for the manufacture of these substances, fungicidal compositions which contain these substances as the active ingredient and the use of such substances and compositions for the control of fungi in agriculture and in horticulture.

  该发明涉及一种新的吡啶衍生物，其化学式为##STR1## 其中X表示一个基团##STR2##，R.sup.1，R.sup.2，R.sup.3，R.sup.4和R.sup.5具有描述中给出的含义，以及它们的N-氧化物，N-氨基盐，铜络合物和酸加成盐，制造这些物质的过程，包含这些物质作为活性成分的杀真菌组合物，以及在农业和园艺中控制真菌的使用这些物质和组合物。
• Fungicidal pyridine derivatives for use in agriculture
  申请人：Hoffmann-La Roche Inc.

  公开号：US04699652A1

  公开（公告）日：1987-10-13

  The invention is directed to fungicidal pyridine derivatives and their N-amino salts and acid addition salts, said pyridine derivatives having the formula ##STR1## wherein R is mono-, di- or trisubstituted phenyl, wherein the substituents are the same or different and are selected from the group consisting of 1 to 3 halogen, 1 or 2 C.sub.1-3 -alkyl, 1 or 2 C.sub.1-3 -alkoxy and 1 or 2 trifluoromethyl moieties; R.sup.1 is hydrogen, C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl or C.sub.2-6 -alkynyl; R.sup.2 is hydrogen; R.sup.3 is selected from the group consisting of --CO--R.sup.4, --C(OR.sup.5).dbd.CHR.sup.6, --CH(R.sup.4)OR.sup.5, --C(R.sup.4).dbd.NOR.sup.7 and ##STR2## R.sup.4 is hydrogen or C.sub.1-5 -alkyl; R.sup.5 is C.sub.1-4 -alkyl; R.sup.6 and R.sup.7 are hydrogen or C.sub.1-4 -alkyl; n is 2 or 3; or R.sup.2 taken together with R.sup.4 is equal to the group --CH.dbd.CH-- (vinylene); as well as to fungicidal compositions containing these compounds as the active substance, and to the use of the fungicidal pyridine derivatives, their N-amino salts and their acid addition salts in a method of combatting the growth of fungi in agriculture and in horticulture.

  本发明涉及抗真菌性吡啶衍生物及其N-氨基盐和酸加成盐，所述吡啶衍生物具有以下式子：##STR1## 其中R为单取代、双取代或三取代苯基，所述取代基相同或不同，选自由1至3个卤素、1或2个C.sub.1-3烷基、1或2个C.sub.1-3烷氧基和1或2个三氟甲基基团的群；R.sup.1为氢、C.sub.1-6烷基、C.sub.2-6烯基或C.sub.2-6炔基；R.sup.2为氢；R.sup.3选自以下群：--CO--R.sup.4、--C(OR.sup.5).dbd.CHR.sup.6、--CH(R.sup.4)OR.sup.5、--C(R.sup.4).dbd.NOR.sup.7和##STR2## R.sup.4为氢或C.sub.1-5烷基；R.sup.5为C.sub.1-4烷基；R.sup.6和R.sup.7为氢或C.sub.1-4烷基；n为2或3；或R.sup.2与R.sup.4共同等于--CH.dbd.CH--（乙烯基）；以及含有这些化合物作为活性物质的抗真菌组合物，以及在农业和园艺中使用这些抗真菌性吡啶衍生物、它们的N-氨基盐和它们的酸加成盐的方法来对抗真菌的生长。
• Pyridine derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US04556661A1

  公开（公告）日：1985-12-03

  Novel pyridine and pyrazine derivatives of the formula ##STR1## wherein R.sup.4 is 3-pyridyl, 3-pyridyl-1-oxide, 2-pyrazinyl, 2-pyrazinyl-1-oxide, 2-pyrazinyl-4-oxide or 2-pyrazinyl-1,4-dioxide, and R, R.sup.1, R.sup.2 and R.sup.3 are as hereinafter set forth, processes for their preparation, fungicidal compositions containing said compounds, and methods for the use of such compounds or compositions for combatting fungi in agriculture and in horticulture are disclosed. Novel starting materials and fungicidal active substances of the formula ##STR2## wherein R.sup.4' is 3-pyridyl or 2-pyrazinyl, and R and R.sup.1" as hereinafter set forth, which are used for the preparation of the compounds of formula I, and their N-oxides, as well as fungicidal compositions containing these compounds as the active substance, are also described.

  本发明公开了化学式为##STR1##的新型吡啶和吡唑衍生物，其中R.sup.4为3-吡啶基，3-吡啶基-1-氧化物，2-吡嗪基，2-吡嗪基-1-氧化物，2-吡嗪基-4-氧化物或2-吡嗪基-1,4-二氧化物，R，R.sup.1，R.sup.2和R.sup.3如下所述，以及制备它们的方法，包含这些化合物的杀菌组合物，以及在农业和园艺中使用这些化合物或组合物对抗真菌的方法。还公开了化学式为##STR2##的新型起始材料和杀菌活性物质，其中R.sup.4'为3-吡啶基或2-吡嗪基，R和R.sup.1"如下所述，用于制备式I的化合物和它们的N-氧化物，以及包含这些化合物作为活性物质的杀菌组合物。
• Certain fungicidal alphabenzyl-3-pyridylmethanol, the corresponding
  申请人：Hoffmann-La Roche Inc.

  公开号：US04753947A1

  公开（公告）日：1988-06-28

  Novel pyridine and pyrazine derivatives of the formula ##STR1## wherein R.sup.4 is 3-pyridyl, 3-pyridyl-1-oxide, 2-pyrazinyl, 2-pyrazinyl-1-oxide, 2-pyrazinyl-4-oxide or 2-pyrazinyl-1,4-dioxide, and R, R.sup.1, R.sup.2 and R.sup.3 are as hereinafter set forth, processes for their preparation, fungicidal compositions containing said compounds, and methods for the use of such compounds or compositions for combatting fungi in agriculture and in horticulture are disclosed. Novel starting materials and fungicidal active substances of the formula ##STR2## wherein R.sup.4' is 3-pyridyl or 2-pyrazinyl, and R and R.sup.1" as hereinafter set forth, which are used for the preparation of the compounds of formula I, and their N-oxides, as well as fungicidal compositions containing these compounds as the active substance, are also described.

  本发明涉及一种新的吡啶和吡唑衍生物，其化学式为## STR1 ##其中R.sup.4为3-吡啶基，3-吡啶基-1-氧化物，2-吡唑基，2-吡唑基-1-氧化物，2-吡唑基-4-氧化物或2-吡唑基-1,4-二氧化物，而R，R.sup.1，R.sup.2和R.sup.3如下所述，揭示了制备这些化合物的过程，包含所述化合物的杀菌组合物，以及使用这些化合物或组合物在农业和园艺中对抗真菌的方法。还描述了化学式## STR2 ##中R.sup.4'为3-吡啶基或2-吡唑基，而R和R.sup.1"如下所述的新起始材料和杀菌活性物质，用于制备化学式I的化合物及其N-氧化物，以及包含这些化合物作为活性物质的杀菌组合物。