2-benzyl-4-methyl-3,6-dihydro-2H-pyran

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 2-benzyl-4-methyl-3,6-dihydro-2H-pyran
• 化学式: C₁₃H₁₆O
• 分子量: 188.269
• InChiKey: IBMHTGFRRBSTFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-甲基-3-丁烯-1-醇 、 氧化苯乙烯 在 indium(III) chloride 作用下， 以 氯仿 为溶剂， 反应 5.0h， 以83%的产率得到2-benzyl-4-methyl-3,6-dihydro-2H-pyran
  参考文献：
  名称：

  Synthesis of tetrahydropyran derivatives via a novel indium trichloride mediated cross-cyclization between epoxides and homoallyl alcohols

  摘要：

  A cross-cyclization between epoxides and homoallyl alcohols catalyzed by indium chloride generates tetrahydropyran derivatives in high yields. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)02114-6

文献信息

• An efficient synthesis of dihydro- and tetrahydropyrans via oxonium–ene cyclization reaction
  作者：Somasekhar Bondalapati、Udagandla C. Reddy、Pipas Saha、Anil K. Saikia

  DOI：10.1039/c1ob00033k

  日期：——

  An efficient method has been developed for the synthesis of 2,3-dihydropyrans and 4-methylenetetrahydropyrans from aldehydes and substituted homoallyl alcohols in benzene mediated by boron trifluoride etherate in good yields. The reaction proceeds viaoxonium–ene reaction.

  已开发出一种有效的方法，用于从醛和取代的烯丙基醇中合成2，3-二氢吡喃和4-亚甲基四氢吡喃。 苯 由...介导 三氟化硼醚化物丰产。该反应通过-烯反应进行。
• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANIQUES
  申请人：GIVAUDAN SA

  公开号：WO2020079052A1

  公开（公告）日：2020-04-23

  The present invention refers to dihydropyran derivatives, and to a process of making the same. The invention further refers to perfume compositions and fragranced articles comprising them.

  本发明涉及二氢吡喃衍生物及其制备方法。该发明还涉及香水组合物和含有它们的香气制品。
• ORGANIC COMPOUNDS
  申请人：Givaudan SA

  公开号：US20210355411A1

  公开（公告）日：2021-11-18

  The present invention refers to dihydropyran derivatives, and to a process of making the same. The invention further refers to perfume compositions and fragranced articles comprising them.
• Synthesis of tetrahydropyran derivatives via a novel indium trichloride mediated cross-cyclization between epoxides and homoallyl alcohols
  作者：Jianke Li、Chao-Jun Li

  DOI：10.1016/s0040-4039(00)02114-6

  日期：2001.1

  A cross-cyclization between epoxides and homoallyl alcohols catalyzed by indium chloride generates tetrahydropyran derivatives in high yields. (C) 2001 Elsevier Science Ltd. All rights reserved.