3-溴-7H-苯并[DE]苯并[4,5]咪唑并[2,1-A]异喹啉-7-酮 | 26559-67-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 中文名称: 3-溴-7H-苯并[DE]苯并[4,5]咪唑并[2,1-A]异喹啉-7-酮
• 英文名称: 3-bromo-7H-benz[de]benzimidazo[2,1-a]isoquinoline-7-one
• 英文别名: 3-bromobenzo[d,e]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one；3-Bromo-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one；17-bromo-3,10-diazapentacyclo[10.7.1.02,10.04,9.016,20]icosa-1(20),2,4,6,8,12,14,16,18-nonaen-11-one
• CAS: 26559-67-1
• 化学式: C₁₈H₉BrN₂O
• 分子量: 349.186
• InChiKey: GMHAZZMVKAUVPL-UHFFFAOYSA-N

物化性质

• 熔点：
  276-278 °C
• 沸点：
  641.5±57.0 °C(Predicted)
• 密度：
  1.70±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P264,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P362,P403+P233,P501
• 危险性描述：
  H315,H319,H335
• 储存条件：
  存储条件：2-8℃，干燥。

反应信息

• 作为反应物：
  描述：

  3-溴-7H-苯并[DE]苯并[4,5]咪唑并[2,1-A]异喹啉-7-酮 以 甲醇 、 二氯甲烷 为溶剂， 反应 71.5h， 生成 3,3'-((2-((7-oxo-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-3-yl)amino)ethyl)azanediyl)bis(N-(2-aminoethyl)propanamide)
  参考文献：
  名称：

  The synthesis and study of fluorescent PAMAM-based dendritic molecules

  摘要：

  New water soluble and fluorescent PAMAM-based dendritic molecules based on the naphthalimide derivative 7H-benz[de]benzimidazo[2,1-a]isoquinoline-7-one as the fluorescent unit, have been prepared and their photophysical properties studied in aqueous solution over a wide pH range. The dendrons are all strongly fluorescent through an intramolecular charge transfer (ICT) excited state, but this can be modulated by photoinduced electron transfer (PeT) processes, which increases with higher PAMAM dendron generation. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.07.054
• 作为产物：
  描述：

  苊 在 N-溴代丁二酰亚胺(NBS) 、 sodium dichromate 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 10.0h， 生成 3-溴-7H-苯并[DE]苯并[4,5]咪唑并[2,1-A]异喹啉-7-酮
  参考文献：
  名称：

  Naphthalimide-based optical turn-on sensor for monosaccharide recognition using boronic acid receptor

  摘要：

  一种荧光受体/GO纳米平台。利用新设计的功能发展的PET在葡萄糖感应中具有35倍的响应增强（从关闭到开启）。增强发生在快速选择性GO脱附过程中。

  DOI：

  10.1039/c9ra01757g

文献信息

• Reagents and methods for direct labeling of nucleotides
  申请人：Naleway John J.

  公开号：US20130150254A1

  公开（公告）日：2013-06-13

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活重氮衍生物以用于标记核苷酸的系统和方法。通过将可检测基团的稳定的肼酰肼衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成核苷酸的标记。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，所有类型的核苷酸都可以在不经过扩增或改变的情况下进行标记。
• USE OF SUBSTITUTED PERYLENES IN ORGANIC SOLAR CELLS
  申请人：KÖNEMANN Martin

  公开号：US20110308592A1

  公开（公告）日：2011-12-22

  The present invention relates to an organic solar cell with a photoactive region which comprises at least one organic donor material in contact with at least one organic acceptor material, wherein the donor material and the acceptor material form a donor-acceptor heterojunction and wherein the photoactive region comprises at least one substituted perylene.

  本发明涉及一种有机太阳能电池，其具有包括至少一种有机给体材料与至少一种有机受体材料接触的光活性区域，其中给体材料和受体材料形成给体-受体异质结，且光活性区域包括至少一种取代的苝。
• TERRYLENE COMPOUNDS, PREPARATION THEREOF AND USE THEREOF IN ORGANIC SOLAR CELLS
  申请人：Könemann Martin

  公开号：US20120234380A1

  公开（公告）日：2012-09-20

  A terrylene compound of formula I: wherein R 1 to R 4 are each independently an unsubstituted or substituted alkyl, aryl, thiophenyl or oligothiophenyl group, or a hydrogen atom. Two adjacent radicals selected from R 1 to R 4 , together with the carbon atoms of the benzene ring to which they are bonded, may also form a fused ring system having 1 to 8 additional rings. With the carbon atoms to which it is bonded, A forms a fused monocyclic, dicyclic, tricyclic, tetracyclic, pentacyclic or hexacyclic ring system which optionally contains one or more independently selected substituents. A process for preparing the terrylene compound. An organic solar cell with a photoactive region including at least one organic donor material in contact with at least one organic acceptor material, the donor material and the acceptor material forming a donor-acceptor heterojunction, and the photoactive region including at least one such terrylene compound.

  公式I的苯基化合物：其中R1至R4分别独立地是未取代或取代的烷基、芳基、噻吩基或寡噻吩基，或氢原子。从R1至R4中选择的相邻基团，与它们结合的苯环的碳原子一起，也可以形成具有1至8个额外环的融合环系统。与它结合的碳原子一起，A形成一个融合的单环、双环、三环、四环、五环或六环系统，该系统可以选择性地包含一个或多个独立选择的取代基。一种制备苯基化合物的方法。一种有机太阳能电池，其光活性区域包括至少一种有机给体材料与至少一种有机受体材料接触，给体材料和受体材料形成给受体异质结，光活性区域包括至少一种这样的苯基化合物。
• [EN] TERRYLENE COMPOUNDS, PREPARATION THEREOF AND USE THEREOF IN ORGANIC SOLAR CELLS<br/>[FR] COMPOSÉS TERRYLÈNES, LEUR PRÉPARATION ET LEUR UTILISATION DANS DES CELLULES SOLAIRES ORGANIQUES
  申请人：BASF SE

  公开号：WO2012123888A1

  公开（公告）日：2012-09-20

  A terrylene compound of the formula I and processes for preparation thereof are disclosed, (I) in which R1, R2, R3 and R4 are each independently selected from hydrogen and in each case unsubstituted or substituted alkyl, aryl, thiophenyl and oligothiophenyl; or in each case at least two adjacent radicals selected from the R1, R2, R3 and R4 radicals, together with the carbon atoms of the benzene ring to which they are bonded, may also be a fused ring system having 1, 2, 3, 4, 5, 6, 7 or 8 further rings, and A with the carbon atoms to which it is bonded is a fused monocyclic, dicyclic, tricyclic, tetracyclic, pentacyclic or hexacyclic ring system which optionally bears one or more independently selected substituents. Further disclosed is an organic solar cell with a photoactive region which comprises at least one organic donor material in contact with at least one organic acceptor material, wherein the photoactive region comprises at least one such terrylene compound.

  本公开了一种化学式I的苝基化合物及其制备方法，其中R1、R2、R3和R4分别独立地选自氢和未取代或取代的烷基、芳基、噻吩基和寡硫代噻吩基；或者在R1、R2、R3和R4基团中至少有两个相邻基团，连同它们结合的苯环的碳原子，也可以是具有1、2、3、4、5、6、7或8个进一步环的融合环系统；以及与其结合的碳原子的A是一个融合的单环、双环、三环、四环、五环或六环环系统，可选地带有一个或多个独立选择的取代基。此外，还公开了一种有机太阳能电池，其具有至少一个有机给体材料与至少一个有机受体材料接触的光活性区域，其中光活性区域至少包含一个这样的苝基化合物。
• Fructose recognition using new “Off–On” fluorescent chemical probes based on boronate-tagged 1,8-naphthalimide
  作者：Sanaz Seraj、Shohre Rouhani、Farnoush Faridbod

  DOI：10.1039/c8nj05092a

  日期：——

  synthesis of small chemical receptors. Two new water-soluble fluorescent selectophores have been successfully synthesized and their selectivity has been studied in sensing saccharides. The synthesized selectophores indicated selectivity toward fructose compared to other tested saccharides within the range of 0.16 to 50 mM at the physiological pH 7.4. The designed fluorescent probes were used to measure the

  最近发现，遗传性果糖不耐受症（HFI）和血糖水平可能是糖尿病或某些代谢性疾病的重要指标。随着时间的流逝，荧光有机分子已广泛用于选择性识别各种分析物。这项工作引入了基于硼酸酯标记的1,8-萘二甲酰亚胺的新型合成分子，该分子具有平面结构和高融合环，可用于果糖的快速光学检测。与二醇形成五元硼酸酯的硼酸在合成小型化学受体中已变得越来越流行。已经成功地合成了两种新的水溶性荧光选择基，并且已经研究了它们在糖类传感中的选择性。与其他测试的糖相比，在生理pH 7.4范围内，合成的选择基表明对果糖的选择性在0.16至50 mM范围内。设计的荧光探针用于测量果糖玉米糖浆中果糖的百分比。结果表明，（2-（（（2-（（7-oxo-7H-苯并[ d，e ]苯并[4,5]咪唑并[2,1 - a ]异喹啉-3-基）氨基）乙基）氨基）甲基）苯基）硼酸（NONB）探针能够确定浓度果糖含量令人满意，表明该探针可潜在地用于实际样品中果糖的定量检测。