2,2-二氯环丙基苯砜 | 38435-04-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,2-二氯环丙基苯砜
• 英文名称: 1,1-Dichloro-2-(phenylsulfonyl)cyclopropane
• 英文别名: 1,1-Dichloro-2-phenylsulfonylcyclopropane；1,1-Dichlor-2-phenyl-sulfonylcyclopropan；1.1-Dichlor-2-phenylsulfonyl-cyclopropan；2,2-Dichlorocyclopropyl phenyl sulfone；(2,2-dichlorocyclopropyl)sulfonylbenzene
• CAS: 38435-04-0
• 化学式: C₉H₈Cl₂O₂S
• mdl: MFCD00100733
• 分子量: 251.133
• InChiKey: XPHUXLOBBBGMAU-UHFFFAOYSA-N

物化性质

• 熔点：
  83-88 °C
• 密度：
  1.3934 (estimate)
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2904909090
• 安全说明：
  S24/25
• 储存条件：
  存于阴凉干燥处

SDS

Name:	2 2-Dichlorocyclopropyl phenyl sulfone Material Safety Data Sheet
Synonym:	[(2,2-Dichlorocyclopropyl)sulfonyl]benzen
CAS:	38435-04-0

Section 1 - Chemical Product MSDS Name:2 2-Dichlorocyclopropyl phenyl sulfone Material Safety Data Sheet
Synonym:[(2,2-Dichlorocyclopropyl)sulfonyl]benzen

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
38435-04-0	2,2-Dichlorocyclopropyl phenyl sulfone	ca. 100	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.Hygroscopic (absorbs moisture from the air).Moisture sensitive.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Antidote: None reported.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam. Do NOT get water inside containers.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation. Do not get water inside containers.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Do not allow contact with water. Keep from contact with moist air and steam.
Storage:
Store in a tightly closed container. Keep under a nitrogen blanket.
Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 38435-04-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 87 - 88 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C9H8Cl2O2S
Molecular Weight: 251.13

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, moisture.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 38435-04-0 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2,2-Dichlorocyclopropyl phenyl sulfone - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 38435-04-0: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 38435-04-0 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 38435-04-0 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2,2-二氯环丙基苯砜 在 盐酸 作用下， 生成 3-(苯磺酰)丙酸
  参考文献：
  名称：

  Reaction of 1,1-dichloro-2-phenylsulfonylcyclopropanes with sodium alkoxides

  摘要：

  DOI：

  10.1021/jo00947a025
• 作为产物：
  描述：

  2,2-二氯环丙基苯硫醚 在 双氧水 作用下， 以 溶剂黄146 为溶剂， 生成 2,2-二氯环丙基苯砜
  参考文献：
  名称：

  Reactions of Enol Ethers with Carbenes. III.¹ Vinyl Sulfides and Δ³-Dihydrothiapyran²

  摘要：

  DOI：

  10.1021/jo01031a025

文献信息

• Reactions of Organic Anions; CXLIX.¹Reactions of<i>gem</i>-Dichlorocyclopropanes Containing an Electron-Withdrawing Substituent with Organic Anions Generated with Phase-Transfer Catalysis
  作者：Michał Fedoryński、Agnieszka Dybowska、Andrzej Jończyk

  DOI：10.1055/s-1988-27635

  日期：——

  gem- Dichlorocyclopropanes 1 react with C-H, O-H and S-H acids in the presence of concentrated sodium hydroxide solution and a phase-transfer catalyst to give gem-disubstituted cyclopropanes 2 or chain products 3 in 44-95% yield.

  双氯环丙烷1在浓氢氧化钠溶液和相转移催化剂的存在下，与碳氢、氧氢和硫氢酸反应，生成双取代环丙烷2或链状产物3，产率可达44-95%。
• A new approach to synthesis of gem-difluorocyclopropanes substituted with electron withdrawing group
  作者：Andrzej Jończyk、Grzegorz Kaczmarczyk

  DOI：10.1016/0040-4039(96)00739-3

  日期：1996.6

  gem-Dichlorocyclopropanes 1 react with tetra-n-butylammonium fluoride trihydrate in DMF or with potassium fluoride and tetra-n-butylammonium hydrogen sulphate in acetonitrile/water mixture, to afford gem-difluorocyclopropanes 2, in moderate yields.

  宝石-二氯环丙烷1与DMF中的四正丁基氟化铵三水合物或在乙腈/水混合物中与氟化钾和硫酸四正丁基铵在乙腈/水混合物中反应，以中等收率得到宝石-二氟环丙烷2。
• Prilezhaeva,E.P. et al., Doklady Chemistry, 1962, vol. 144, p. 533 - 535
  作者：Prilezhaeva,E.P. et al.

  DOI：——

  日期：——
• Reaction of 1,1-dichloro-2-phenylsulfonylcyclopropanes with sodium alkoxides
  作者：William E. Parham、William D. McKown、Victor Nelson、Shoji Kajigaeshi、Norio Ishikawa

  DOI：10.1021/jo00947a025

  日期：1973.4
• Reactions of Enol Ethers with Carbenes. III.¹ Vinyl Sulfides and Δ³-Dihydrothiapyran²
  作者：William E. Parham、Lynette Christensen、Siemen H. Groen、R. M. Dodson

  DOI：10.1021/jo01031a025

  日期：1964.8