1-甲氧基-4-[1-(4-甲氧基苯基)-2-甲基丙基]苯 | 4741-75-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-甲氧基-4-[1-(4-甲氧基苯基)-2-甲基丙基]苯
• 英文名称: 1,1-bis(4-methoxyphenyl)-2-methylpropane
• 英文别名: 1,1-bis-(4-methoxy-phenyl)-2-methyl-propane；1,1-Bis-(4-methoxy-phenyl)-2-methyl-propan；Benzene, 1,1'-(2-methylpropylidene)bis(4-methoxy-；1-methoxy-4-[1-(4-methoxyphenyl)-2-methylpropyl]benzene
• CAS: 4741-75-7
• 化学式: C₁₈H₂₂O₂
• mdl: MFCD01657563
• 分子量: 270.371
• InChiKey: AAIMXWKRWRKLOT-UHFFFAOYSA-N

物化性质

• 沸点：
  177-181 °C(Press: 1 Torr)
• 密度：
  1.010±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,1-bis(4-methoxypheny)ethanol 在 Ca zeolite 、 CaY zeolite 、 对甲苯磺酸 作用下， 以 乙醚 、 正己烷 、 苯 为溶剂， 反应 7.0h， 生成 1-甲氧基-4-[1-(4-甲氧基苯基)-2-甲基丙基]苯
  参考文献：
  名称：

  Activation Conditions Play a Key Role in the Activity of Zeolite CaY:  NMR and Product Studies of Brønsted Acidity

  摘要：

  CaY, activated under different conditions, was characterized with H-1, (31)p, and H-1/27AI double resonance MAS NMR. The H-1 MAS NMR spectra of CaY, calcined in an oven at 500 degrees C, shows resonances from H2O (bound to Ca2+ and the zeolite framework), CaOH+, aluminum hydroxides, silanols, and Bronsted acid sites. No evidence for Lewis acidity is observed on adsorption of trimethylphosphine, and an estimate of approximate to 16 Bronsted acid sites per unit cell is obtained for this sample. CaY activated in an oven at higher temperatures contains less water, but all the other species are still present. In contrast, CaY activated by slow ramping of the temperature under vacuum to 500 or 600 degrees C shows a; much lower concentration of Bronsted acid sites (<1/unit cell). Again, no evidence for Lewis acidity was observed. These NMR results have been utilized to understand the very different product distributions that are observed for reactions of 1,1- and 1,2-diarylethylenes in zeolite CaY activated in an oven (in air) and under vacuum. Samples with high concentrations of Bronsted acid sites react stoichiometrically with these sites, yielding diarylalkanes. At low concentrations, the Bronsted acid sites can act catalytically resulting in isomerization reactions.

  DOI：

  10.1021/jp980385w

文献信息

• Catalytic selective bis-arylation of imines with anisole, phenol, thioanisole and analogues
  作者：Cong-Rong Liu、Man-Bo Li、Cui-Feng Yang、Shi-Kai Tian

  DOI：10.1039/b800066b

  日期：——

  The first highly efficient double Friedel–Crafts reaction of N-tosyl imines with anisole, phenol, thioanisole and analogues has been developed to produce the corresponding symmetric diarylmethanes and triarylmethanes with high regioselectivity in the presence of a catalytic amount of Bi2(SO4)3–TMSCl at room temperature.

  首次开发了一种高效的N-甲苯磺酰亚胺与茴香醚、苯酚、硫代茴香醚及其类似物的双弗里德尔-克拉夫茨反应，在室温下，使用催化量的Bi2(SO4)3-TMSCl，以高区域选择性制备相应的对称二芳基甲烷和三芳基甲烷。
• Room-Temperature Bismuth-Catalyzed Bis-arylation of Carbonyl Compounds with Aryl Ethers and Phenols
  作者：Congrong Liu、Manbo Li

  DOI：10.1002/cjoc.201300522

  日期：2013.10

  Using Bi2(SO4)3 as the catalyst and TMSCl as the additive, a wide variety of aldehydes, ketones, and acetals were smoothly condensed with aryl ethers at room temperature to provide the corresponding diarylmethanes and triarylmethanes selectively in good to excellent yields.

  使用Bi 2（SO 4）3作为催化剂和TMSCl作为添加剂，在室温下将各种醛，酮和乙缩醛与芳基醚平稳缩合，以良好的收率选择性地提供相应的二芳基甲烷和三芳基甲烷。
• SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE
  申请人：Shionogi & Co., Ltd.

  公开号：EP2444400A1

  公开（公告）日：2012-04-25

  This invention provides compounds having antiviral activities especially inhibiting activity for influenza virus, more preferably provides substituted 3-hydroxy-4-pyridone derivatives having cap-dependent endonuclease inhibitory activity.

  本发明提供了具有抗病毒活性，特别是对流感病毒有抑制活性的化合物，更优选提供了具有帽依赖性内切酶抑制活性的取代 3-羟基-4-吡啶酮衍生物。
• Substituted polycyclic carbamoyl pyridone derivative prodrug
  申请人：Shionogi & Co., Ltd.

  公开号：US10202379B2

  公开（公告）日：2019-02-12

  The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3-hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory activity.

  本发明提供了一种具有抗病毒作用，特别是对流感病毒具有生长抑制活性的化合物，该化合物的一个优选实例是具有帽依赖性内切酶抑制活性的取代 3-羟基-4-吡啶酮衍生物原药。
• The Structure and Toxicity of DDT Insecticides
  作者：E. F. Rogers、H. D. Brown、I. M. Rasmussen、R. E. Heal

  DOI：10.1021/ja01108a060

  日期：1953.6