4-肼基-6-甲基-2-(甲硫基)嘧啶 | 1980-54-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 4-肼基-6-甲基-2-(甲硫基)嘧啶
• 英文名称: 4-hydrazino-6-methyl-2-(methylsulfanyl)pyrimidine
• 英文别名: 6-methyl-2-methylsulfanylpyrimidin-4-ylhydrazine；4-hydrazino-6-methyl-2-methylsulfanyl-pyrimidine；(6-methyl-2-methylsulfanyl-pyrimidin-4-yl)-hydrazine；(6-Methyl-2-methylmercapto-pyrimidin-4-yl)-hydrazin；(2-Methylmercapto-4-methyl-6-pyrimidinyl)-hydrazin；2-Methylmercapto-4-hydrazino-6-methyl-pyrimidin；4-Hydrazino-6-methyl-2-(methylthio)pyrimidine；(6-methyl-2-methylsulfanylpyrimidin-4-yl)hydrazine
• CAS: 1980-54-7
• 化学式: C₆H₁₀N₄S
• mdl: MFCD08691666
• 分子量: 170.238
• InChiKey: IICQWDJYVKCOTB-UHFFFAOYSA-N

物化性质

• 熔点：
  142-143 °C
• 沸点：
  309.0±25.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  89.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-肼基-6-甲基-2-(甲硫基)嘧啶 在 potassium hydroxide 作用下， 以 乙醇 、 水 、 正丁醇 为溶剂， 反应 4.0h， 生成 4,4'-((4-nitrophenyl)methylene)bis(3-methyl-1-(6-methyl-2-(methylthio)pyrimidin-4-yl)-1H-pyrazol-5-ol) compound with diethylamine (1:1)
  参考文献：
  名称：

  1-(Pyrimidin-4-yl)pyrazol-5(4H)-one derivatives: I. Synthesis of 3-methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-pyrazol-5-ol and specificity of its Knoevenagel reaction

  摘要：

  3-Methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-1H-pyrazol-5-ol available via cyclocondensation of 6-methyl-2-methylsulfanylpyrimidin-4-ylhydrazine with ethyl acetoacetate reacted with aromatic aldehydes to give two kinds of products, 4-arylmethylidene-5-oxo-4,5-dihydropyrazole and arylbis(5-hydroxypyrazol-4-yl)methane derivatives, depending on the substituent in the aromatic aldehyde.

  DOI：

  10.1134/s1070363211020186
• 作为产物：
  描述：

  6-甲基-2-甲硫基-4-氯嘧啶 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以48%的产率得到4-肼基-6-甲基-2-(甲硫基)嘧啶
  参考文献：
  名称：

  1-(Pyrimidin-4-yl)pyrazol-5(4H)-one derivatives: I. Synthesis of 3-methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-pyrazol-5-ol and specificity of its Knoevenagel reaction

  摘要：

  3-Methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-1H-pyrazol-5-ol available via cyclocondensation of 6-methyl-2-methylsulfanylpyrimidin-4-ylhydrazine with ethyl acetoacetate reacted with aromatic aldehydes to give two kinds of products, 4-arylmethylidene-5-oxo-4,5-dihydropyrazole and arylbis(5-hydroxypyrazol-4-yl)methane derivatives, depending on the substituent in the aromatic aldehyde.

  DOI：

  10.1134/s1070363211020186

文献信息

• Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates
  申请人：DowElanco

  公开号：EP0343752A1

  公开（公告）日：1989-11-29

  Alkoxy substituted 1,2,4-triazolo[1,5-c]­pyrimidine-2-sulfonamides are general and selective pre- and postemergence herbicides. These compounds are disclosed which are prepared from alkoxy substituted 1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonyl halides by condensation with substituted N-trialkylsilylanilines and by other methods.

  烷氧基取代的 1,2,4-三唑并[1,5-c]嘧啶-2-磺酰胺类化合物是一般的和选择性的芽前和芽后除草剂。已公开的这些化合物是由烷氧基取代的 1,2,4-三唑并[1,5-c]嘧啶-2-磺酰卤通过与取代的 N-三烷基硅烷胺缩合或通过其他方法制备而成。
• Claesen; Vanderhaeghe, Bulletin des Societes Chimiques Belges, 1959, vol. 68, p. 30,55
  作者：Claesen、Vanderhaeghe

  DOI：——

  日期：——
• 5-Aryl-1-[pyrimidin-2(4)-yl]-3-phenyl-4,5-dihydro-1H-pyrazoles. Synthesis from substituted 2(4)-hydrazinopyrimidines and fragmentation under positive electrospray ionization
  作者：A. V. Erkin、O. S. Yuzikhin、V. I. Krutikov

  DOI：10.1134/s1070428016080133

  日期：2016.8

  Reaction of substituted 2(4)-hydrazinopyrimidines with 3-aryl-1-phenyl-2-propen-1-ones in the presence of a base results prevailingly in 5-aryl-1-[pyrimidin-2(4)-yl]-3-phenyl-4,5-dihydro-1H-pyrazoles. The fragmentation path of these compounds under positive electrospray ionization consists in simultaneous decomposition of their heterocyclic fragments.
• BROWN D. J.; NAGAMATSU T., AUSTRAL. J. CHEM., 1979, 32, NO 7, 1585-1593
  作者：BROWN D. J.、 NAGAMATSU T.

  DOI：——

  日期：——
• Abdel-Fattah Abdel-Samei M., Sherif Sherif M., Youssef Mohamed M., Ahmed +, J. Chem. Res. Synop, (1994) N 11, S 412-413
  作者：Abdel-Fattah Abdel-Samei M., Sherif Sherif M., Youssef Mohamed M., Ahmed +

  DOI：——

  日期：——

表征谱图