4-ethoxy-2,3-difluoro-1,1'-biphenyl-4'-boronic acid | 470461-10-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-ethoxy-2,3-difluoro-1,1'-biphenyl-4'-boronic acid
• 英文别名: [4-(4-ethoxy-2,3-difluorophenyl)phenyl]boronic acid
• CAS: 470461-10-0
• 化学式: C₁₄H₁₃BF₂O₃
• 分子量: 278.063
• InChiKey: OLOOHRNUIBVNOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.71
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-ethoxy-2,3-difluoro-1,1'-biphenyl-4'-boronic acid 、 1-溴-3-氟-4-碘苯 在 bis-triphenylphosphine-palladium(II) chloride potassium carbonate 作用下， 以 Solmix A-11 、 水 、 甲苯 为溶剂， 反应 2.0h， 以82.8%的产率得到4'-bromo-4-ethoxy-2,3,2''-trifluoro-1,1'-terphenyl
  参考文献：
  名称：

  TETRA- OR PENTA-CYCLIC LIQUID CRYSTALLINE COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT

  摘要：

  公开号：

  EP2206695B1
• 作为产物：
  描述：

  硼酸三甲酯 、 4-bromo-4'-ethoxy-2,3-difluoro-1,1-biphenyl 在 正丁基锂 、 盐酸 、 水 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以81.1%的产率得到4-ethoxy-2,3-difluoro-1,1'-biphenyl-4'-boronic acid
  参考文献：
  名称：

  TETRA- OR PENTA-CYCLIC LIQUID CRYSTALLINE COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT

  摘要：

  公开号：

  EP2206695B1

文献信息

• Four- or five-ring liquid crystal compound having lateral fluorine, liquid crystal composition, and liquid crystal display device
  申请人：JNC Corporation

  公开号：US08187494B2

  公开（公告）日：2012-05-29

  The invention provides a liquid crystal compound having stability to heat, light and so forth, a wide temperature range of a nematic phase, a small viscosity, a suitable optical anisotropy, and a suitable elastic constant K33, and further having a suitable and negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds, and a liquid crystal composition having stability to heat, light and so forth, a low viscosity, a large optical anisotropy, a suitable and negative dielectric anisotropy, and a suitable elastic constant K33, a low threshold voltage, a high maximum temperature (phase-transition temperature on a nematic phase-isotropic phase) of a nematic phase, and a low minimum temperature of the nematic phase. The liquid crystal compound which has a specific structure having fluorine at a lateral position and also having phenylene in which hydrogen on the benzene ring is replaced by fluorine, and a liquid crystal composition containing the compound are prepared.

  该发明提供了一种具有对热、光等具有稳定性、具有宽温度范围的向列相、具有较小粘度、适当的光学各向异性和适当的弹性常数K33，并且具有适当且负的介电各向异性以及与其他液晶化合物具有良好的相容性的液晶化合物，以及具有对热、光等具有稳定性、低粘度、较大的光学各向异性、适当且负的介电各向异性、适当的弹性常数K33、低阈值电压、高向列相的最高温度（向列相-等向相的相变温度）和低向列相的最低温度的液晶组合物。制备了具有特定结构的液晶化合物，其在侧位具有氟，并且苯环上的氢被氟取代，以及含有该化合物的液晶组合物。
• FOUR- OR FIVE-RING LIQUID CRYSTAL COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：Kobayashi Masahide

  公开号：US20100309402A1

  公开（公告）日：2010-12-09

  The invention provides a liquid crystal compound having stability to heat, light and so forth, a wide temperature range of a nematic phase, a small viscosity, a suitable optical anisotropy, and a suitable elastic constant K 33 , and further having a suitable and negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds, and a liquid crystal composition having stability to heat, light and so forth, a low viscosity, a large optical anisotropy, a suitable and negative dielectric anisotropy, and a suitable elastic constant K 33 , a low threshold voltage, a high maximum temperature (phase-transition temperature on a nematic phase-isotropic phase) of a nematic phase, and a low minimum temperature of the nematic phase. The liquid crystal compound which has a specific structure having fluorine at a lateral position and also having phenylene in which hydrogen on the benzene ring is replaced by fluorine, and a liquid crystal composition containing the compound are prepared.

  本发明提供了一种液晶化合物，具有耐热、耐光等稳定性，广泛的向列相温度范围，低粘度，适当的光学各向异性和适当的弹性常数K33，进一步具有适当且负的介电各向异性和与其他液晶化合物优异的相容性，以及一种液晶组合物，具有耐热、耐光等稳定性，低粘度，大的光学各向异性，适当且负的介电各向异性，适当的弹性常数K33，低阈值电压，向列相的高最大温度（向列相-等向相相变温度）和低向列相的最低温度。制备了一种具有侧位氟和苯环上氢被氟取代的苯基的特定结构的液晶化合物以及含有该化合物的液晶组合物。
• TETRA- OR PENTA-CYCLIC LIQUID CRYSTALLINE COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT
  申请人：JNC Corporation

  公开号：EP2206695B1

  公开（公告）日：2013-09-18