Aethylenglykol-octylaether-benzylaether | 93541-24-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Aethylenglykol-octylaether-benzylaether
• 英文别名: (2-Octyloxy-ethoxymethyl)-benzene；2-octoxyethoxymethylbenzene
• CAS: 93541-24-3
• 化学式: C₁₇H₂₈O₂
• 分子量: 264.408
• InChiKey: XVKOWRUSWRBYGX-UHFFFAOYSA-N

物化性质

• 沸点：
  122 °C(Press: 0.1 Torr)
• 密度：
  0.932±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Aethylenglykol-octylaether-benzylaether 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 N-辛基单氧乙烯
  参考文献：
  名称：

  Synthesis and antiproliferative activity of alkylphosphocholines

  摘要：

  Alkylphosphocholines (APC) with one or more methylene groups in the alkyl chain replaced by oxygen atoms or carbonyl groups, or both have been assembled modularly using w-diols as central building blocks. Out of 25 new compounds of this kind, I I were evaluated for their antiproliferative activity on four cell lines and compared with miltefosine to evaluate their hemolytic activity (HA); and cytotoxicity on non-tumoral cells (MT2), used as markers of adverse effects. Compound 13 was more active on cancer cell lines than on non-tumoral cells and the data were similar for MTT and thymidine incorporation assays. It had less HA than miltefosine, Compound 13 could therefore be a candidate for the preparation of compounds with higher cytotoxicity on cancer cells and lower general toxicity. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

  DOI：

  10.1016/j.chemphyslip.2003.08.002
• 作为产物：
  描述：

  1-溴辛烷 在 sodium 作用下， 生成 Aethylenglykol-octylaether-benzylaether
  参考文献：
  名称：

  Konstitution und physikalische Eigenschaften von �thern, 7. Mitt.: Unterschiedlich substituierte Glykol- und Pentaerythrit�ther

  摘要：

  DOI：

  10.1007/bf00904461

文献信息

• Konstitution und physikalische Eigenschaften von �thern, 7. Mitt.: Unterschiedlich substituierte Glykol- und Pentaerythrit�ther
  作者：R. Riemschneider、P. Gros

  DOI：10.1007/bf00904461

  日期：——
• Synthesis and antiproliferative activity of alkylphosphocholines
  作者：Mandy Agresta、Paola D’Arrigo、Ezio Fasoli、Daniele Losi、Giuseppe Pedrocchi-Fantoni、Simona Riva、Stefano Servi、Davide Tessaro

  DOI：10.1016/j.chemphyslip.2003.08.002

  日期：2003.12

  Alkylphosphocholines (APC) with one or more methylene groups in the alkyl chain replaced by oxygen atoms or carbonyl groups, or both have been assembled modularly using w-diols as central building blocks. Out of 25 new compounds of this kind, I I were evaluated for their antiproliferative activity on four cell lines and compared with miltefosine to evaluate their hemolytic activity (HA); and cytotoxicity on non-tumoral cells (MT2), used as markers of adverse effects. Compound 13 was more active on cancer cell lines than on non-tumoral cells and the data were similar for MTT and thymidine incorporation assays. It had less HA than miltefosine, Compound 13 could therefore be a candidate for the preparation of compounds with higher cytotoxicity on cancer cells and lower general toxicity. (C) 2003 Elsevier Ireland Ltd. All rights reserved.