4-(1-甲基-1-苯基-乙基)-苯甲醚 | 6623-93-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(1-甲基-1-苯基-乙基)-苯甲醚
• 英文名称: 4-(1-methyl-1-phenyl-ethyl)-anisole
• 英文别名: 1-methoxy-4-(2-phenylpropan-2-yl)benzene
• CAS: 6623-93-4
• 化学式: C₁₆H₁₈O
• 分子量: 226.318
• InChiKey: QFRZPXZJXKYCIW-UHFFFAOYSA-N

物化性质

• 沸点：
  154-156 °C(Press: 3 Torr)
• 密度：
  1.0424 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909309090

反应信息

• 作为反应物：
  描述：

  4-(1-甲基-1-苯基-乙基)-苯甲醚 在 氢溴酸 作用下， 生成 4-肉桂苯酚
  参考文献：
  名称：

  Highlights of Drought Policy and Related Science in Australia and the U.S.A.

  摘要：

  Patterns of water supply and use in Australia and the U.S.A. differ in many ways. This results in different perceptions concerning the nature of drought and policy approaches to its management. This paper discusses the differences and similarities and explores lessons that policy makers in both countries can learn from one another. A key difference between the two countries is that whereas drought is perceived in Australia essentially in terms of its impact on agriculture, in the U.S. both perceptions and policy are also heavily influenced by the impact of drought on urban communities. This has led to different policy emphases. In 1992 Australia established its National Drought Policy; the U.S. is presently considering the adoption of a national drought policy. These policies highlight drought being accepted as part of natural climate variability, rather than as a natural disaster. They also emphasize the protection of the natural resource base.

  DOI：

  10.1080/02508060108686927
• 作为产物：
  描述：

  2-苯基-2-丙醇 在 盐酸 、 三氯化铝 、 sodium 作用下， 生成 4-(1-甲基-1-苯基-乙基)-苯甲醚
  参考文献：
  名称：

  Reactions of t-Butylperoxy Isopropyl Carbonate with Aromatic Compounds under Friedel-Crafts Conditions¹

  摘要：

  DOI：

  10.1021/jo01346a007

文献信息

• Versatile Friedel-Crafts-Type Alkylation of Benzene Derivatives Using a Molybdenum Complex/ortho-Chloranil Catalytic System
  作者：Yoshihiko Yamamoto、Kouhei Itonaga

  DOI：10.1002/chem.200801105

  日期：——

  molybdenum complexes catalyze Friedel-Crafts-type alkylation reactions of benzene derivatives with alkenes and alcohols in the presence of an organic oxidant, o-chloranil. The utilization of [Mo(CO)(6)] and two equivalents of o-chloranil catalytically furnished the hydroarylation product of norbornene with p-xylene at 80 degrees C, whereas [Cr(CO)(6)] and [W(CO)(6)] failed to catalyze the same reaction, thus

  在有机氧化剂邻氯苯甲醛的存在下，多种钼配合物催化苯衍生物与烯烃和醇的弗里德-克来福特（Friedel-Crafts）型烷基化反应。利用[Mo（CO）（6）]和两当量的邻氯苯甲酰在80℃催化降冰片烯与对二甲苯的加氢芳基化产物，而[Cr（CO）（6）]和[W（CO） ）（6）]未能催化相同的反应，因此表明了钼源的重要性。当使用钼（II）配合物[CpMoCl（CO）（3）]（Cp =环戊二烯基）作为预催化剂时，可获得最佳结果。加氢芳基化反应也发生在苯乙烯，环己烯和1-己烯作为烯烃底物的情况下。亲电取代机理是基于邻位/对位选择性和对水合产物的马尔可夫尼科夫选择性提出的。在[CpMoCl（CO）（3）] /邻氯苯甲腈催化体系存在下，仲醇，苄醇或烯丙基醇以相似的选择性参与了苯的烷基化，这一事实进一步证实了我们的假设。
• Molybdenum-Catalyzed Aromatic Substitution with Olefins and Alcohols
  作者：Isao Shimizu、Kuok Meng Khien、Miki Nagatomo、Takayuki Nakajima、Akio Yamamoto

  DOI：10.1246/cl.1997.851

  日期：1997.9

  A new type of electrophilic aromatic substitution without using organic halides has been realized by using Mo(CO)6 catalyst.

  使用Mo(CO)6催化剂实现了一种新型无机卤化物的电芳香取代反应。
• Cationic Iron(III) Porphyrin Catalyzed Dehydrative Friedel-Crafts Reaction of Alcohols with Arenes
  作者：Takuya Kurahashi、Seijiro Matsubara、Satoru Teranishi

  DOI：10.1055/s-0033-1339640

  日期：——

  Alcohols react with arenes in the presence of cationic iron(III) porphyrin catalyst. The reaction involves the formation of the C–C bond via dehydration, which is formal Lewis acid catalyzed Friedel–Crafts reaction.

  醇在阳离子铁 (III) 卟啉催化剂存在下与芳烃反应。该反应涉及通过脱水形成 C-C 键，这是正式的路易斯酸催化的弗里德尔-克拉夫茨反应。
• Ligand‐Enabled Nickel‐Catalyzed Redox‐Relay Migratory Hydroarylation of Alkenes with Arylborons
  作者：Yuli He、Chuang Liu、Lei Yu、Shaolin Zhu

  DOI：10.1002/anie.202001742

  日期：2020.6.2

  A redox-relay migratory hydroarylation of isomeric mixtures of olefins with arylboronic acids catalyzed by nickel complexes bearing diamine ligands is described. A range of structurally diverse 1,1-diarylalkanes, including those containing a 1,1-diarylated quaternary carbon, were obtained in excellent yields and with high regioselectivity. Preliminary experimental evidence supports the proposed non-dissociated

  描述了由带有二胺配体的镍配合物催化的烯烃与芳基硼酸的异构体混合物的氧化还原-中继迁移氢化芳基化。以优异的产率和高区域选择性获得了一系列结构多样的1，1-二芳基烷烃，包括那些含有1，1-二芳基化季碳的烷烃。初步的实验证据支持了在苄基位置进行选择性还原消除之前，芳烃-镍（II）-氢化物物种沿着烯烃的烷基链的非离解链走动。证明低至0.5mol％的催化剂负载量对于大规模合成是足够的，同时保持高反应性，突出了该转化的实用价值。
• Highly efficient iodine-catalyzed hydroarylation of arenes with styrenes
  作者：Cheng-Ming Chu、Wan-Ju Huang、Ju-Tsung Liu、Ching-Fa Yao

  DOI：10.1016/j.tetlet.2007.07.178

  日期：2007.9

  Iodine mediates the hydroarylation of styrenes with arenes and heteroarenes to afford 1,1-diarylalkanes in good to high yields. Details regarding the substrate scope and selectivity of this hydroarylation reaction are discussed.

  碘介导苯乙烯与芳烃和杂芳烃的加氢芳基化反应，从而以高收率或高收率提供1,1-二芳基烷烃。讨论了有关该加氢芳基化反应的底物范围和选择性的细节。

表征谱图