p-methoxyphenyl(phenyl)methyl p-tolyl sulfone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-methoxyphenyl(phenyl)methyl p-tolyl sulfone
• 英文别名: 1-methoxy-4-(phenyl(tosyl)methyl)benzene；(4-methoxy-phenyl)-phenyl-(toluene-4-sulfonyl)-methane；(+/-)-[Phenyl-(4-methoxy-phenyl)-methyl]-p-tolyl-sulfon；(+/-)-p-Tolylsulfon-phenyl-(4-methoxy-phenyl)-methan；(4-Methoxy-phenyl)-phenyl-(toluol-4-sulfonyl)-methan；(+/-)-p-Tolyl-(4-methoxy-benzhydryl)-sulfon；1-[(4-Methoxyphenyl)-phenylmethyl]sulfonyl-4-methylbenzene；1-[(4-methoxyphenyl)-phenylmethyl]sulfonyl-4-methylbenzene
• 化学式: C₂₁H₂₀O₃S
• 分子量: 352.454
• InChiKey: GYTDVBBBQKXYFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲氧基二苯甲醇 在 氯仿 、 双氧水 、 溶剂黄146 作用下， 生成 p-methoxyphenyl(phenyl)methyl p-tolyl sulfone
  参考文献：
  名称：

  Balfe et al., Journal of the Chemical Society, 1946, p. 797,802

  摘要：

  DOI：

文献信息

• Copper-Catalyzed Nitrogen Loss of Sulfonylhydrazones: A Reductive Strategy for the Synthesis of Sulfones from Carbonyl Compounds
  作者：Xing-Wen Feng、Jian Wang、Ji Zhang、Jing Yang、Na Wang、Xiao-Qi Yu

  DOI：10.1021/ol101955x

  日期：2010.10.1

  An efficient method for the synthesis of sulfones via nitrogen loss of sulfonyl hydrazones is described. The reaction was performed in the presence of simple copper salt and base by utilization of sulfonyl hydrazones, which were easily prepared from carbonyl compounds. A wide variety of aryl and alkyl sulfones were obtained in moderate to good yields.

  描述了一种通过磺酰基的氮损失合成砜的有效方法。该反应在简单的铜盐和碱的存在下通过利用磺酰基来进行，所述磺酰基易于从羰基化合物制备。以中等至良好的产率获得了各种各样的芳基和烷基砜。
• Balfe et al., Journal of the Chemical Society, 1942, p. 605,610
  作者：Balfe et al.

  DOI：——

  日期：——
• Direct sulfonylation of Baylis–Hillman alcohols and diarylmethanols with TosMIC in ionic liquid-[Hmim]HSO4: an unexpected reaction
  作者：Garima、Vishnu P. Srivastava、Lal Dhar S. Yadav

  DOI：10.1016/j.tetlet.2011.06.096

  日期：2011.9

  A Bronsted acidic ionic liquid-[Hmim]HSO4 promoted unexpected reaction of Baylis-Hillman alcohols and diarylmethanols with p-toluenesulfonylmethyl isocyanide (TosMIC) affording the corresponding sulfone derivatives instead of N-tosylmethyl amides is reported. After isolation of the product, the ionic liquid [Hmim]HSO4 was easily recycled for further use. (C) 2011 Elsevier Ltd. All rights reserved.
• Palladium-catalyzed benzylic direct arylation of benzyl sulfones with aryl halides
  作者：Takashi Niwa、Hideki Yorimitsu、Koichiro Oshima

  DOI：10.1016/j.tet.2009.01.030

  日期：2009.3

  An effective palladium catalyst system for the direct arylation of benzyl sulfones with aryl halides has been developed. The catalytic reaction provides a facile route to diarylmethyl sulfones. The products can be transformed further via desulfonylative functionalization mediated by aluminum compounds. (C) 2009 Elsevier Ltd. All rights reserved.