4,4',4''-(pyridine-2,4,6-triyl)triphenol | 103504-13-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4,4',4''-(pyridine-2,4,6-triyl)triphenol
• 英文别名: 4-[2,6-Bis(4-hydroxyphenyl)pyridin-4-yl]phenol；4-[2,6-bis(4-hydroxyphenyl)pyridin-4-yl]phenol
• CAS: 103504-13-8
• 化学式: C₂₃H₁₇NO₃
• 分子量: 355.393
• InChiKey: DLLSVLONMLTGFQ-UHFFFAOYSA-N

物化性质

• 沸点：
  561.4±45.0 °C(Predicted)
• 密度：
  1.297±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,4',4''-(pyridine-2,4,6-triyl)triphenol 、 硫酸二甲酯 生成 2,4,6-tris(4-methoxyphenyl)pyridine
  参考文献：
  名称：

  Hopff et al., Chimia, 1959, vol. 13, p. 105

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4,6-tris(4-methoxyphenyl)pyridine 在 盐酸 作用下， 生成 4,4',4''-(pyridine-2,4,6-triyl)triphenol
  参考文献：
  名称：

  Dilthey, Journal fur praktische Chemie (Leipzig 1954), 1921, vol. <2>102, p. 226

  摘要：

  DOI：

文献信息

• Acidic ionic liquid immobilized on cellulose: an efficient and recyclable heterogeneous catalyst for the solvent-free synthesis of hydroxylated trisubstituted pyridines
  作者：Shailesh P. Satasia、Piyush N. Kalaria、Dipak K. Raval

  DOI：10.1039/c3ra23052j

  日期：——

  The synthesis of a novel cellulose supported acidic ionic liquid (Cell-IL) for the solvent-free synthesis of hydroxylated trisubstituted pyridines is reported. Cell-IL was prepared by immobilization of an acidic ionic liquid [1-butyl-3-(3-trimethoxypropyl)-1H-imidazol-3-ium hydrogen sulfate] on cellulose. The viability of this concept has been confirmed by FT-IR, TGA-DTG, 1H NMR and elemental analysis. The Cell-IL showed good thermal stability and exhibited a high catalytic activity in the synthesis of a series of hydroxylated trisubstituted pyridines. It was recovered and reused for the model reaction three times without an appreciable change in its activity.

  报道了一种新型纤维素支持的酸性离子液体（Cell-IL）的合成，用于无溶剂合成羟基化三取代吡啶。Cell-IL是通过将一种酸性离子液体（[1-丁基-3-(3-三甲氧基丙基)-1H-咪唑-3-ium氢硫酸盐]）固定在纤维素上制备的。通过FT-IR、TGA-DTG、1H NMR和元素分析确认了该概念的可行性。Cell-IL显示出良好的热稳定性，并在一系列羟基化三取代吡啶的合成中表现出高催化活性。它被回收并在模型反应中重复使用三次，其活性没有显著变化。
• Solvent- and catalyst-free synthesis of new hydroxylated trisubstituted pyridines under microwave irradiation
  作者：Guodong Yin、Qiong Liu、Junrui Ma、Nengfang She

  DOI：10.1039/c2gc35243e

  日期：——

  A facile solvent- and catalyst-free method for the synthesis of a series of new hydroxylated 2,4,6-trisubstituted pyridines under microwave irradiation was developed. The expected products were obtained through a simplified purification process without protection of the hydroxyl group. UV-Vis and fluorescence spectra of these conjugated multi-hydroxyl compounds were also investigated.

  开发了一种简便的无溶剂和无催化剂的方法，用于在微波辐射下合成一系列新的羟基化的2,4,6-三取代的吡啶。通过简化的纯化过程无需保护羟基即可获得预期的产物。还研究了这些共轭多羟基化合物的UV-Vis和荧光光谱。