3β-propyloxycarbonyloxycholestene-5 | 38577-26-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-propyloxycarbonyloxycholestene-5
• 英文别名: propyl-cholesteryl carbonate；Kohlensaeure-propylester-cholesterylester；Propyl-cholesteryl-carbonat；(3beta)-Cholest-5-en-3-yl propyl carbonate；[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] propyl carbonate
• CAS: 38577-26-3
• 化学式: C₃₁H₅₂O₃
• 分子量: 472.752
• InChiKey: HDCRAXGDAFODLS-GTPODGLVSA-N

物化性质

• 沸点：
  550.5±20.0 °C(Predicted)
• 密度：
  1.01±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  cholesterol 、 氯甲酸丙酯 在 吡啶 、 苯 作用下， 生成 3β-propyloxycarbonyloxycholestene-5
  参考文献：
  名称：

  Daeumer,E., Diss. S. 27

  摘要：

  DOI：

文献信息

• Implants for localized drug delivery and methods of use thereof
  申请人：The Regents of the University of California

  公开号：US10912933B2

  公开（公告）日：2021-02-09

  Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.

  本文提供了一种向目标组织输送疏水活性剂的植入物。该植入物可包括界定第一表面和与第一表面相对的第二表面的支架，其中支架基本上不渗透疏水活性剂，以及具有可渗透活性剂壁的硅胶管，其中硅胶管的第一长度贴在支架的第一表面上，其中硅胶管的两端从第一表面延伸，并且第一长度内的第二长度的硅胶管所勾勒的路径是迂回的。此外，还提供了一种使用植入物向目标组织局部递送疏水活性剂的方法，以及可用于实施本方法的试剂盒。
• Robberecht, Bulletin des Societes Chimiques Belges, 1938, vol. 47, p. 597,614
  作者：Robberecht

  DOI：——

  日期：——
• COATINGS FOR IMPLANTABLE MEDICAL DEVICES FOR LIPOSOME DELIVERY
  申请人：Miv Therapeutics Inc.

  公开号：EP2136856A1

  公开（公告）日：2009-12-30
• IMPLANTS FOR LOCALIZED DRUG DELIVERY AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：EP3183026A1

  公开（公告）日：2017-06-28
• Implants for Localized Drug Delivery and Methods of Use Thereof
  申请人：KIRIAKIS Jim

  公开号：US20170224970A1

  公开（公告）日：2017-08-10

  Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.