Z-3-chloro-2-(benzylsulfinyl)propenamide | 1043925-81-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Z-3-chloro-2-(benzylsulfinyl)propenamide
• CAS: 1043925-81-0
• 化学式: C₁₀H₁₀ClNO₂S
• 分子量: 243.714
• InChiKey: UTDNTWVHGROOIA-TWGQIWQCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  60.16
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  Z-3-chloro-2-(benzylsulfinyl)propenamide 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Investigation of the chemoselective and enantioselective oxidation of α-thio-β-chloroacrylamides

  摘要：

  An investigation of the chemoselective and enantioselective oxidation of alpha-thio-beta-chloroacrylamides is described. The alpha-thio-beta-chloroacrylamides can be selectively oxidised to either the racemic sulfoxide or the sulfone very efficiently. The asymmetric sulfur oxidation of alpha-thio-beta-chloroacrylamides is also discussed, with sulfoxide enantioselectivities of up to 52% ee achieved using the Kagan oxidation, and up to 71% ee when the Bolm oxidation is employed. While the enantioselectivities achieved are modest, these are among the most highly functionalised sulfides investigated in catalytic asymmetric oxidation, and the resulting enantioenriched sulfoxides have significant synthetic potential. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.04.033
• 作为产物：
  描述：

  Z-3-chloro-2-(benzylthio)propenamide 在 Oxone 作用下， 以 水 、 丙酮 为溶剂， 反应 2.0h， 以46%的产率得到Z-3-chloro-2-(benzylsulfinyl)propenamide
  参考文献：
  名称：

  Investigation of the chemoselective and enantioselective oxidation of α-thio-β-chloroacrylamides

  摘要：

  An investigation of the chemoselective and enantioselective oxidation of alpha-thio-beta-chloroacrylamides is described. The alpha-thio-beta-chloroacrylamides can be selectively oxidised to either the racemic sulfoxide or the sulfone very efficiently. The asymmetric sulfur oxidation of alpha-thio-beta-chloroacrylamides is also discussed, with sulfoxide enantioselectivities of up to 52% ee achieved using the Kagan oxidation, and up to 71% ee when the Bolm oxidation is employed. While the enantioselectivities achieved are modest, these are among the most highly functionalised sulfides investigated in catalytic asymmetric oxidation, and the resulting enantioenriched sulfoxides have significant synthetic potential. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.04.033

文献信息

• 1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanes
  作者：Marie Kissane、Simon E. Lawrence、Anita R. Maguire

  DOI：10.1039/c002479a

  日期：——

  2-Thio-3-chloroacrylamides undergo 1,3-dipolar cycloadditions with diazoalkanes leading to a series of novel pyrazolines and pyrazoles. The mechanistic and synthetic features of the cycloadditions to the 2-thio-3-chloroacrylamides at both the sulfide and sulfoxide levels of oxidation are rationalised on the basis of the nature of the substituents.

  2-硫代-3-氯丙烯酰胺与重氮烷进行1,3-偶极环加成反应，生成一系列新颖的吡唑啉和吡唑。在两个表面上2-硫-3-氯丙烯酰胺的环加成反应的机理和合成特征硫化物 根据取代基的性质合理地确定氧化亚砜和亚砜的氧化水平。