1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol | 173676-57-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol
• 英文别名: 1-phenyl-2-pyrrolidin-1-yl-propan-1-ol；1-phenyl-2-pyrrolidino-propan-1-ol；(1S,2R)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol；1-phenyl-2-pyrrolidin-1-ylpropan-1-ol
• CAS: 173676-57-8
• 化学式: C₁₃H₁₉NO
• 分子量: 205.3
• InChiKey: FZVHJGJBJLFWEX-UHFFFAOYSA-N

物化性质

• 沸点：
  321.3±22.0 °C(Predicted)
• 密度：
  1.075±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol 在 水 、 sodium hydroxide 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 1.0h， 生成 (1S,2R)-1-苯基-2-(1-吡咯烷基)-1-丙醇
  参考文献：
  名称：

  [EN] NOVEL PROCESS FOR PREPARATION OF OPTICALLY PURE NOREPHEDRINE AND ITS DERIVATIVES
  [FR] NOUVEAU PROCÉDÉ DE PRÉPARATION DE NORÉPHÉDRINE OPTIQUEMENT PURE ET DE SES DÉRIVÉS

  摘要：

  公开号：

  WO2015063795A3
• 作为产物：
  描述：

  α-pyrrolidinopropiophenone hydrochloride 在 水 、 钯 作用下， 生成 1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol
  参考文献：
  名称：

  Compounds Containing the Pyrrolidine Ring. Analogs of Sympathomimetic Amines

  摘要：

  DOI：

  10.1021/ja01110a033

文献信息

• [EN] PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE CARBAMATES CYCLIQUES
  申请人：LONZA AG

  公开号：WO2012048886A1

  公开（公告）日：2012-04-19

  The invention is directed to a process for the preparation of a cyclic carbamate starting with o-aminobenzyl alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgene and mixtures thereof, and in that the reaction carried out in the presence of an aqueous base, and a water-immiscible organic solvent, said organic solvent mainly comprising at least one compound selected from C2-5-alkyl C2-5-carboxylates and mixtures of at least one C2-5-alkyl C2-5-carboxylate with at least one C5-8-alkane.

  本发明涉及一种以邻氨基苄醇和/或适当的盐为起始物，通过选择光气、偶氮二磷、三光气及其混合物作为环化剂进行反应，并在水溶性碱和与水不混溶的有机溶剂存在下进行该反应的环状碳酸酯的制备方法，所述有机溶剂主要由至少一种C2-5-烷基C2-5-羧酸酯和至少一种C2-5-烷基C2-5-羧酸酯与至少一种C5-8-烷烃的混合物组成。
• Process for the synthesis of chiral propargylic alcohols
  申请人：Lonza Ltd

  公开号：EP2447247A1

  公开（公告）日：2012-05-02

  A process for the synthesis of chiral propargylic alcohols.

  手性丙炔醇的合成过程。
• Process for the synthesis of cyclic carbamates
  申请人：Lonza Ltd

  公开号：EP2447255A1

  公开（公告）日：2012-05-02

  The invention is directed to a process for the preparation of a cyclic carbamate starting with a chiral propargylic alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgene and mixtures thereof, and in that the reaction is carried out in the presence of an aqueous base, and a water-immiscible organic solvent, said organic solvent mainly comprising at least one compound selected from C2-5-alkyl C2-5-carboxylates and mixtures of at least one C2-5-alkyl C2-5-carboxylate with at least one C5-8-alkane. Another aspect of the invention is directed to a process for the synthesis of said cyclic carbamate starting described above, wherein also a process for the preparation of the chiral propargylic alcohol is provided.

  该发明涉及一种以手性丙炔醇和/或其适当盐为起始物，与从光气、二光气、三光气和它们的混合物中选择的环化试剂反应，且在水性碱和水不相溶的有机溶剂存在下进行反应的制备环氧羰基化合物的方法，所述有机溶剂主要包括至少一种选择自C2-5-烷基C2-5-羧酸酯和至少一种C5-8-烷烃的混合物的化合物。该发明的另一个方面涉及一种合成上述环氧羰基化合物的方法，其中还提供了一种制备手性丙炔醇的方法。
• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF A NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR<br/>[FR] PROCÉDÉ AMÉLIORÉ DE PRÉPARATION D'UN INHIBITEUR NON NUCLÉOSIDIQUE DE LA TRANSCRIPTASE INVERSE
  申请人：DISCOVERY INTERMEDIATES PRIVATE LTD

  公开号：WO2015118515A1

  公开（公告）日：2015-08-13

  The present invention relates to an improved process for the preparation of a non-nucleoside reverse transcriptase inhibitor. Specifically, the present invention relates to an improved process for the preparation of Efavirenz of Formula 1. The present invention also relates to a process for the preparation of compound of Formula 2, an intermediate used in the preparation of Efavirenz, wherein X is a halogen atom; X1 is a leaving group.

  本发明涉及一种改进的非核苷类逆转录酶抑制剂制备工艺。具体来说，本发明涉及一种改进的制备EFAVIRENZ（化学式1）的工艺。本发明还涉及一种制备化合物（化学式2）的工艺，该化合物是制备EFAVIRENZ时使用的中间体，其中X为卤原子；X1为离去基团。
• [EN] 1-ACYL-PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS<br/>[FR] DERIVES DE 1-ACYL-PYRROLIDINE DESTINES AU TRAITEMENT D'INFECTIONS VIRALES
  申请人：GLAXO GROUP LTD

  公开号：WO2004037818A1

  公开（公告）日：2004-05-06

  Anti-viral agents of Formula (I) wherein: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or optionally substituted C1-6alkyl; J represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl;and salts, solvates and esters thereof; provided that when A is esterified to form -OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl;processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.

  化学式（I）的抗病毒剂其中：A代表羟基；D代表芳基或杂芳基；E代表氢、C1-6烷基、芳基、杂芳基或杂环烷基；G代表氢或可选择地取代的C1-6烷基；J代表C1-6烷基、杂环烷基烷基、芳基烷基或杂芳基烷基；及其盐、溶剂合物和酯；提供它们的制备方法、包含它们的药物组合物以及在丙型肝炎病毒治疗中使用它们的方法。