5-sulfamoyl-2-mercaptobenzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5-sulfamoyl-2-mercaptobenzimidazole
• 英文别名: 2-Sulfanylidene-1,3-dihydrobenzimidazole-5-sulfonamide
• 化学式: C₇H₇N₃O₂S₂
• 分子量: 229.283
• InChiKey: ZTBOGYHFAQFCPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,5-二溴戊烷 、 5-sulfamoyl-2-mercaptobenzimidazole 以86%的产率得到1,5-bis(5-sulfamoyl-2-benzimidazoylthio)pentane
  参考文献：
  名称：

  2-mercaptobenzimidazole derivatives and antihyperlipemic agent or

  摘要：

  以下公式所代表的2-巯基苯并咪唑衍生物，其类似物和盐被披露：##STR1## 这些2-巯基苯并咪唑衍生物可用作药物，如抗高脂血症药物或抗动脉粥样硬化药物，也可用作银卤化物感光材料、液晶等的添加剂。

  公开号：

  US05962493A1

文献信息

• LITHOGRAPHIC PRINTING PLATE PRECURSOR AND LITHOGRAPHIC PRINTING PROCESS
  申请人：OOHASHI Hidekazu

  公开号：US20110054212A1

  公开（公告）日：2011-03-03

  A lithographic printing plate precursor, which comprises: a support; an image-recording layer; and a protective layer, in this order, wherein at least one of the image-recording layer and the protective layer comprises a phosphonium salt having a specific structure, and a lithographic printing process, which comprises: exposing a lithographic printing plate precursor; supplying an oil-based ink and a fountain solution comprising a phosphonium salt having a specific structure to the exposed lithographic printing plate precursor on a printing machine to remove an unexposed area of an image-recording layer; and conducting printing.

  一种光刻印刷版前体，包括：支撑体；图像记录层；以及保护层，依次排列，其中图像记录层和保护层中至少有一层包含具有特定结构的磷酸铵盐；以及一种光刻印刷工艺，包括：曝光光刻印刷版前体；在印刷机上向曝光的光刻印刷版前体提供具有特定结构的磷酸铵盐的油墨和喷泉溶液，以去除图像记录层中未曝光区域；进行印刷。
• COMPOUNDS USEFUL AS ANTIBIOTIC TOLERANCE INHIBITORS
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US20160052890A1

  公开（公告）日：2016-02-25

  The disclosure provides compounds and pharmaceutical compositions of the compounds useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds and salts of general Formula VIII Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a patient, including Pseudomonas aeruginosa infections, are also provided by the disclosure.

  本公开提供了化合物和药物组合物，这些化合物对治疗慢性和急性细菌感染有用。其中一些化合物是通式VIII的化合物和盐。本公开的某些化合物是MvfR抑制剂。MvfR抑制剂减少抗生素耐药细菌株的形成，对治疗革兰氏阴性细菌感染和减少铜绿假单胞菌的毒性有用。本公开还提供了治疗患者细菌感染的方法，包括铜绿假单胞菌感染。
• Lithographic printing plate precursor and lithographic printing process
  申请人：Fuji Photo Film Co., Ltd.

  公开号：EP1754597A2

  公开（公告）日：2007-02-21

  A lithographic printing plate precursor, which comprises: a support; an image-recording layer; and a protective layer, in this order, wherein at least one of the image-recording layer and the protective layer comprises a phosphonium salt having a specific structure, and a lithographic printing process, which comprises: exposing a lithographic printing plate precursor; supplying an oil-based ink and a fountain solution comprising a phosphonium salt having a specific structure to the exposed lithographic printing plate precursor on a printing machine to remove an unexposed area of an image-recording layer; and conducting printing.

  一种平版印刷板前体，它依次包括：支撑物；图像记录层；和保护层，其中图像记录层和保护层中的至少一个包括具有特定结构的膦盐，以及一种平版印刷工艺，它包括：曝光平版印刷板前体；在印刷机上向曝光的平版印刷板前体提供油基油墨和包含具有特定结构的鏻盐的润版液，以去除图像记录层的未曝光区域；以及进行印刷。
• 2-MERCAPTOBENZIMIDAZOLE DERIVATIVE AND ANTIHYPERLIPEMIC OR ANTIARTERIOSCLEROTIC AGENT CONTAINING THE SAME
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0742210B1

  公开（公告）日：2001-11-21
• SATO, KOZO;KITAGUCHI, HIROSHI;TAKEUCHI, MASASHI;TSUKASE, MASAAKI;KATO, MA+
  作者：SATO, KOZO、KITAGUCHI, HIROSHI、TAKEUCHI, MASASHI、TSUKASE, MASAAKI、KATO, MA+

  DOI：——

  日期：——