methyl-phenyl-dithiocarbamic acid ; compound with triethylamine | 83073-99-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl-phenyl-dithiocarbamic acid ; compound with triethylamine
• 英文别名: Methyl-phenyl-dithiocarbamidsaeure; Verbindung mit Triaethylamin；N,N-diethylethanamine;methyl(phenyl)carbamodithioic acid
• CAS: 83073-99-8
• 化学式: C₆H₁₅N*C₈H₉NS₂
• 分子量: 284.49
• InChiKey: FOUKCWFTRDGFMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.89
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl-phenyl-dithiocarbamic acid ; compound with triethylamine 在 2-bromo-3-methyl-4-phenylthiazolium fluorosulfonate 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以74%的产率得到N,N'-dimethyl-N,N'-diphenylthiuram sulfide
  参考文献：
  名称：

  Activation of dithiocarbamate by 2-halothiazolium salts

  摘要：

  DOI：

  10.1021/jo00245a025
• 作为产物：
  描述：

  二硫化碳 、 三乙胺 、 N-甲基苯胺 以 乙腈 为溶剂， 生成 methyl-phenyl-dithiocarbamic acid ; compound with triethylamine
  参考文献：
  名称：

  苯乙炔的无金属三官能化：高效的一锅两步合成吉姆-双（二硫代氨基甲酸酯）

  摘要：

  据报道，通过遵循一锅两步策略对苯乙炔体系进行无金属三官能化来合成苯甲酰双（二硫代氨基甲酸酯）。苯乙炔经历分子溴介导的氧化溴化，然后用新制备的二硫代氨基甲酸盐进行亲核取代，该盐是通过胺和CS 2在三乙胺碱存在下迅速反应而制备的。使用各种仲胺和含有不同取代基的苯乙炔体系制备了一系列偕双(二硫代氨基甲酸酯)。

  DOI：

  10.1039/d3ob00712j

文献信息

• Multicomponent synthesis of di-aryl dithiocarbamates <i>via</i> electron donor–acceptor photoactivation with thianthrenium salts
  作者：Min Liu、Yong Qian、Yanqi Wu、Fengzhi Zhang

  DOI：10.1039/d3gc00336a

  日期：——

  and alkyl amines without adding any photocatalysts, transition-metal catalysts, or ligands. A novel photoactivated electron donor–acceptor complex was proposed as the key intermediate. This protocol offers a new approach towards di-aryl dithiocarbamates, thus promising their potential applications in pharmaceutical chemistry and sulfur chemistry.

  在此，从现成的噻蒽盐中有效地开发了一种用于生成二芳基二硫代氨基甲酸酯的多组分、环境友好的方案。使用芳香胺和烷基胺均可顺利进行反应，无需添加任何光催化剂、过渡金属催化剂或配体。提出了一种新型光活化电子供体-受体复合物作为关键中间体。该协议为二芳基二硫代氨基甲酸酯提供了一种新方法，从而有望在药物化学和硫化学中发挥潜在应用。
• Novel dithiocarbamate carbapenems1 with anti-MRSA activity
  作者：Norikazu Ohtake、Hideaki Imamura、Hideo Kiyonaga、Hideki Jona、Masayuki Ogawa、Shigemitsu Okada、Aya Shimizu、Minoru Moriya、Hiroki Sato、Yushin Tominaga、Koji Yamada、Masato Nakano、Ryosuke Ushijima、Susumu Nakagawa

  DOI：10.1016/s0960-894x(97)00272-2

  日期：1997.7

  A new series of carbapenems, in which disubstituted-aminothiocarbonylthio moiety, directly attached to the C-2 position, were prepared and evaluated for their antibacterial potency. These analogs showed potent activity against high-level MRSA, Among them, 9e and 9i were found to exhibit good in vivo efficacy comparable to that of vancomycin, for mouse septicemia model with high-level MRSA. (C) 1997 Elsevier Science Ltd.
• Novel dithiocarbamate carbapenems with anti-MRSA activity
  作者：Norikazu Ohtake、Hideaki Imamura、Hideki Jona、Hideo Kiyonaga、Aya Shimizu、Minoru Moriya、Hiroki Sato、Masato Nakano、Ryosuke Ushijima、Susumu Nakagawa

  DOI：10.1016/s0968-0896(98)00069-8

  日期：1998.7

  A new series of 1 beta-methyl carbapenems, in which a disubstituted-aminothiocarbonylthio moiety was attached to the C-2 position of the carbapenem nucleus, were prepared and evaluated for anti-MRSA activity. These derivatives showed good in vitro antibacterial activity against high-level MRSA, and the finding of good affinity for PBP-2' supported these results. Some of the compounds having favorable protein-binding affinity showed excellent in vivo anti-MRSA activity. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Rhodium Dithiocarbamate Compounds as Metalloligands:  A Controlled Way for the Construction of Binuclear Complexes
  作者：Anabel Elduque、Cristina Finestra、José A. López、Fernando J. Lahoz、Francisco Merchán、Luis A. Oro、M. Teresa Pinillos

  DOI：10.1021/ic971053t

  日期：1998.2.23

  The preparation of N-methyl,N-phenyl-dithiocarbamate mononuclear rhodium(I) complexes is described, and their capability to act as metalloligands for the controlled construction of binuclear dithiocarbamate-bridged species of general formula [Rh-2mu-S2CN(Me)(Ph)}(COD)L-2]BF4 is investigated. Although in the mononuclear complexes the dithiocarbamate group coordinates as an S,S'-chelate ligand, in the reported binuclear compounds this ligand shows a novel bridging eta(2),eta(2)(S,S') coordination mode. EHT calculations based on these binuclear complexes indicate the intermetallic symmetric mu-eta,(2) eta(2)(S,S') coordination to be the most stable situation.
• US4468526A
  申请人：——

  公开号：US4468526A

  公开（公告）日：1984-08-28