6-bromo-1,1-diphenyl-hexane | 637031-09-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-bromo-1,1-diphenyl-hexane
• 英文别名: 6-Brom-1,1-diphenyl-hexan；1-bromo-6,6-diphenylhexane；(6-Bromo-1-phenylhexyl)benzene
• CAS: 637031-09-5
• 化学式: C₁₈H₂₁Br
• 分子量: 317.269
• InChiKey: UQFYCCWAYGUHBT-UHFFFAOYSA-N

物化性质

• 沸点：
  232 °C(Press: 20 Torr)
• 密度：
  1.195±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  6-bromo-1,1-diphenyl-hexane 在 sodium sulfite 作用下， 以 乙醇 、 水 为溶剂， 反应 2.5h， 生成 6,6-diphenylhexane-1-sulfonic acid sodium salt
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS FOR CONTROLLING BACTERIAL VIRULENCE
  [FR] COMPOSES ET PROCEDES DE LUTTE CONTRE LA VIRULENCE DES BACTERIES

  摘要：

  已发现，新型磺化同源丝氨酸内酯化合物I可作为群体感应抑制剂。因此，它们可能在治疗细菌感染方面具有用处。

  公开号：

  WO2003106445A1
• 作为产物：
  描述：

  (6,6-diphenyl-hexyl)-phenyl ether 在 氢溴酸 、 溶剂黄146 作用下， 生成 6-bromo-1,1-diphenyl-hexane
  参考文献：
  名称：

  Nutrition in Cancer Prevention: An Integrated Approach

  摘要：

  There is considerable evidence that the war on cancer is not being won. There is, however, strong evidence that a substantial fraction of cancer can be prevented by using existing nutritional knowledge. In this paper we discuss strategies for reducing cancer incidence by implementing this knowledge. The most obvious route for persuading large numbers to change their diets is by individual counseling in a health-care setting, public education campaigns and interventions at the worksite. However, such health promotion actions have met with only limited success. For efforts to change population diets to be successful, a vital component must include changes in government policies. Examples of the tools that need to be employed are restrictions on advertising and marketing. Effective action will likely require an economic dimension, namely the employment of taxation and subsidies, for instance, by taxing unhealthy food choices and by subsidizing fruit and vegetables.

  DOI：

  10.1080/07315724.2002.10719197

文献信息

• Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers
  作者：Po-wai Yuen、Robert M. Schelkun、Balazs Szoke、Katalin Tarczy-Hornoch

  DOI：10.1016/s0960-894x(98)00440-5

  日期：1998.9

  Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N-type VACC's have been identified. Their synthesis and preliminary pharmacology are discussed herein. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Nutrition in Cancer Prevention: An Integrated Approach
  作者：Norman J. Temple、Audrey L. Balay-Karperien

  DOI：10.1080/07315724.2002.10719197

  日期：2002.4

  There is considerable evidence that the war on cancer is not being won. There is, however, strong evidence that a substantial fraction of cancer can be prevented by using existing nutritional knowledge. In this paper we discuss strategies for reducing cancer incidence by implementing this knowledge. The most obvious route for persuading large numbers to change their diets is by individual counseling in a health-care setting, public education campaigns and interventions at the worksite. However, such health promotion actions have met with only limited success. For efforts to change population diets to be successful, a vital component must include changes in government policies. Examples of the tools that need to be employed are restrictions on advertising and marketing. Effective action will likely require an economic dimension, namely the employment of taxation and subsidies, for instance, by taxing unhealthy food choices and by subsidizing fruit and vegetables.
• [EN] COMPOUNDS AND METHODS FOR CONTROLLING BACTERIAL VIRULENCE<br/>[FR] COMPOSES ET PROCEDES DE LUTTE CONTRE LA VIRULENCE DES BACTERIES
  申请人：QSI PHARMA AS

  公开号：WO2003106445A1

  公开（公告）日：2003-12-24

  Novel sulfonated homoserine lactones formula I have been found to act ac quorum sensing inhibitors. As such, they may be useful in the treatment of bacterial infections.

  已发现，新型磺化同源丝氨酸内酯化合物I可作为群体感应抑制剂。因此，它们可能在治疗细菌感染方面具有用处。