3-(1-Hydroxy-2-pyrrolidinyl)pyridine | 125198-33-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(1-Hydroxy-2-pyrrolidinyl)pyridine
• 英文别名: 2-(pyridin-3-yl)pyrrolidin-1-ol；3-(1-Hydroxypyrrolidin-2-yl)pyridine；3-(1-hydroxypyrrolidin-2-yl)pyridine
• CAS: 125198-33-6
• 化学式: C₉H₁₂N₂O
• 分子量: 164.207
• InChiKey: ZEMOVSBXCGXRQN-UHFFFAOYSA-N

物化性质

• 沸点：
  323.2±31.0 °C(Predicted)
• 密度：
  1.223±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(1-Hydroxy-2-pyrrolidinyl)pyridine 在 palladium on activated charcoal 氢气 作用下， 以 溶剂黄146 为溶剂， 以70%的产率得到3-(吡咯烷-2-基)吡啶
  参考文献：
  名称：

  Tungstate-catalyzed oxidation of secondary amines to nitrones. .alpha.-Substitution of secondary amines via nitrones

  摘要：

  DOI：

  10.1021/jo00293a013
• 作为产物：
  描述：

  (4-Methylsulfonyloxy-4-pyridin-3-ylbutyl) methanesulfonate 在 盐酸羟胺 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 以134 mg的产率得到3-(1-Hydroxy-2-pyrrolidinyl)pyridine
  参考文献：
  名称：

  一种合成尼古丁和大麻素类似物的新方法

  摘要：

  通过将甲磺酰化 1-(3-吡啶基)-1,4 和 1,5-二醇衍生物环化形成吡咯烷基或哌啶基片段，建立了一种直接而实用的合成尼古丁和 anabasine 类似物的方法。尼古丁类似物 ( S ) -15使用先进的非外消旋( R )-1-吡啶-3-基-丁烷-1,4-二醇的氮杂环化方法制备，具有良好的对映选择性，该方法是通过硼烷介导的酮还原获得的12在衍生自二苯基脯氨醇和乙二醇的螺硼酸酯存在下。J. 杂环化学，（2009 年）。

  DOI：

  10.1002/jhet.233

文献信息

• CATALYSTS AND METHODS FOR POLYMER SYNTHESIS
  申请人：NOVOMER, INC.

  公开号：US20130144032A1

  公开（公告）日：2013-06-06

  The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to the active metal center of the complex.

  本发明提供了在二氧化碳和环氧化物的共聚合中具有增强活性的单分子金属配合物。还提供了使用这种金属配合物在合成聚合物中的方法。根据一个方面，本发明提供了包括与具有共催化活性的活化物种相耦合的多齿配体的金属配合物，该多齿配体与复合物的活性金属中心配位。
• PROCESS FOR PREPARING RACEMIC NICOTINE
  申请人：Tian Guanghui

  公开号：US20140031554A1

  公开（公告）日：2014-01-30

  Provided is a process for preparing racemic nicotine from 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof using one-pot process. The process comprises the following steps: 1) in a reaction vessel, reacting 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof in the presence of a suitable solvent and a strong acid by heat; after the reaction is complete, cooling the same and adjusting the pH to 7-8 with alkali; and 2) directly adding a reductant into the above vessel, and after the reaction, purifying the product so as to obtain high purity racemic nicotine or a salt thereof.

  提供了一种使用一锅法从1-甲基-3-烟酰基-2-吡咯酮或其盐制备外消旋尼古丁的方法。该方法包括以下步骤：1）在反应釜中，在适当的溶剂和强酸存在下通过加热反应1-甲基-3-烟酰基-2-吡咯酮或其盐；反应完成后，冷却并用碱调节pH值至7-8；2）直接向上述釜中加入还原剂，在反应后，纯化产物以获得高纯度的外消旋尼古丁或其盐。
• Antibody-catalyzed oxidative degradation of nicotine using riboflavin
  作者：Tobin J. Dickerson、Noboru Yamamoto、Kim D. Janda

  DOI：10.1016/j.bmc.2004.07.006

  日期：2004.9

  Tobacco abuse remains a major cause of death worldwide despite ample evidence linking nicotine to various disease states. Consequently, immunopharmacotherapeutic approaches for the treatment of nicotine abuse have received increasing attention. Although a number of nicotine-binding antibodies have been disclosed, no antibody catalysts exist which efficiently degrade nicotine into pharmacologically inactive substances. Herein, we report the first catalytic antibodies which can oxidatively degrade nicotine. These biocatalysts use the micronutrient riboflavin and visible light as a source of singlet oxygen for the production of reactive oxygen species. Along with various known nicotine metabolites, antibody-catalyzed nicotine oxidations produce two novel nicotine oxidation products that were also detected in control ozonation reactions of nicotine. The reaction is efficient, with multiple turnovers of catalyst observed and total consumption of nicotine attained. These results demonstrate the potential of harnessing riboflavin as an endogenous sensitizer for antibody-catalyzed oxidations and demonstrate a new approach for the development of an active vaccine for the treatment of nicotine addiction using in vivo catalytically active antibodies. (C) 2004 Elsevier Ltd. All rights reserved.
• METHOD FOR PREPARING ARTIFICIALLY SYNTHETIC (R,S)-NICOTINE SALT
  申请人：FEELLIFE HEALTH INC.

  公开号：US20210300889A1

  公开（公告）日：2021-09-30

  The present invention discloses a method for preparing an artificially synthetic (R,S)-nicotine salt, comprising: S1, reacting 4-methylamino-1-(3-pyridine)-butanone hydrochloride and an alkaline substance at −5 to 5° C.; S2, concentrating a reactant obtained in step S1, and adding a first refining solvent for refining to obtain 1-methyl-2-(3-pyridine)-2-pyrrolidinol; S3, adding a reducing agent into 1-methyl-2-(3-pyridine)-2-pyrrolidinol, and reacting at 15 to 35° C.; and S4, concentrating a reactant obtained in step S3, adding a second refining solvent for refining, and then adding an acid for reaction, to obtain the artificially synthetic (R,S)-nicotine salt. The present invention innovatively proposes a two-step method to synthesize the (R,S)-nicotine salt, and the prepared (R,S)-nicotine salt does not contain any other harmful tobacco compounds. The method of the present invention is simple in process, high in product, and suitable for large-scale industrial production.
• US8633123B2
  申请人：——

  公开号：US8633123B2

  公开（公告）日：2014-01-21