(S)-tert-butyl 2-amino-3-cyclohexylpropyl(methyl)carbamate | 942145-58-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-tert-butyl 2-amino-3-cyclohexylpropyl(methyl)carbamate
• 英文别名: tert-butyl (S)-2-amino-3-cyclohexylpropylmethylcarbamate；tert-butyl N-[(2S)-2-amino-3-cyclohexylpropyl]-N-methylcarbamate
• CAS: 942145-58-6
• 化学式: C₁₅H₃₀N₂O₂
• 分子量: 270.415
• InChiKey: LVFHJBJVTNWAFQ-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-tert-butyl 2-amino-3-cyclohexylpropyl(methyl)carbamate 、 N-氰亚胺基-S,S-二硫代碳酸二甲酯 以 乙腈 、 三乙胺 为溶剂， 反应 4.0h， 以to give (S)-tert-butyl 2-((cyanoimino)(methylthio)methylamino)-3-cyclohexylpropyl(methyl)carbamate (450 mg, 31%)的产率得到(S)-tert-butyl 2-((cyanoimino)(methylthio)methylamino)-3-cyclohexylpropyl(methyl)carbamate
  参考文献：
  名称：

  Aspartic Protease Inhibitors

  摘要：

  本发明涉及天冬氨酸蛋白酶抑制剂。本发明所述的某些天冬氨酸蛋白酶抑制剂可以用以下结构式或其药学上可接受的盐来表示。本发明还涉及包括所述天冬氨酸蛋白酶抑制剂的药物组合物。本发明还涉及在需要拮抗一种或多种天冬氨酸蛋白酶的主体中的方法，以及使用所述天冬氨酸蛋白酶抑制剂治疗天冬氨酸蛋白酶介导的疾病的方法。

  公开号：

  US20100048636A1

文献信息

• RENIN INHIBITORS
  申请人：Baldwin John J.

  公开号：US20100190829A1

  公开（公告）日：2010-07-29

  Described are compounds that bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compounds described herein in ameliorating or treating aspartic protease related disorders in a subject in need thereof.

  描述了结合到天冬氨酸蛋白酶以抑制其活性的化合物。它们在治疗或改善与天冬氨酸蛋白酶活性相关的疾病中很有用。还描述了在需要的受试者中使用这些化合物来改善或治疗与天冬氨酸蛋白酶相关的疾病的方法。
• Renin Inhibitors
  申请人：Baldwin John J.

  公开号：US20100144825A1

  公开（公告）日：2010-06-10

  The present invention is directed to aspartic protease inhibitors. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

  本发明涉及天冬氨酸蛋白酶抑制剂。本发明还涉及包含所述天冬氨酸蛋白酶抑制剂的制药组合物。本发明还涉及在需要拮抗一种或多种天冬氨酸蛋白酶的主体中拮抗一种或多种天冬氨酸蛋白酶的方法，以及使用所述天冬氨酸蛋白酶抑制剂治疗天冬氨酸蛋白酶介导的疾病的方法。
• Renin inhibitors
  申请人：Vitae Pharmaceuticals, Inc.

  公开号：US08106221B2

  公开（公告）日：2012-01-31

  The present invention is directed to aspartic protease inhibitors. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

  本发明涉及天冬氨酸蛋白酶抑制剂。本发明还涉及包含所披露的天冬氨酸蛋白酶抑制剂的制药组合物。本发明进一步涉及拮抗一种或多种需要其的天冬氨酸蛋白酶的方法，并使用所披露的天冬氨酸蛋白酶抑制剂治疗天冬氨酸蛋白酶介导的疾病的方法。
• Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
  申请人：Baldwin John J.

  公开号：US08487108B2

  公开（公告）日：2013-07-16

  The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

  本发明涉及天冬氨酸蛋白酶抑制剂。本发明的某些天冬氨酸蛋白酶抑制剂可以用以下结构式或其药学上可接受的盐来表示。本发明还涉及包含所述天冬氨酸蛋白酶抑制剂的制药组合物。本发明还涉及在需要拮抗一种或多种天冬氨酸蛋白酶的受体的主体中的方法，以及使用所述天冬氨酸蛋白酶抑制剂治疗天冬氨酸蛋白酶介导的疾病的方法。
• WO2007/70201
  申请人：——

  公开号：——

  公开（公告）日：——