4-chloro-4'-(chloromethyl)benzophenone | 22494-67-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-4'-(chloromethyl)benzophenone
• 英文别名: 4-(p-Chlorbenzoyl)-benzylchlorid；[4-(Chloromethyl)phenyl]-(4-chlorophenyl)methanone
• CAS: 22494-67-3
• 化学式: C₁₄H₁₀Cl₂O
• 分子量: 265.139
• InChiKey: IGCDHHWVMXVOAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-chloro-4'-(chloromethyl)benzophenone 在 盐酸 、 sodium hydride 、 lithium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.5h， 生成 (+/-)-2-<4-(4-chlorobenzoyl)-2-trifluoromethyl>propionic acid
  参考文献：
  名称：

  Haydock; Mulholland; Telford, European Journal of Medicinal Chemistry, 1984, vol. 19, # 3, p. 205 - 214

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯-4-甲基苯甲酮 在 sodium hypochlorite 、 苄基三乙基氯化铵 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以76%的产率得到4-chloro-4'-(chloromethyl)benzophenone
  参考文献：
  名称：

  Development of a Versatile Methodology for the Synthesis of Poly(2,5-benzophenone) Containing Coil−Rod−Coil Triblock Copolymers

  摘要：

  A short, simple, versatile methodology was developed for the synthesis of poly(2,5-benzophenone) containing coil-rod-coil triblock copolymers. After a model study, poly(2,5-benzophenone) macroinitiators were synthesized via end-capping poly(2,5-dichlorobenzophenone) synthesized by Ni(0)-catalyzed polymerization and functionalization of the chain ends utilizing phase transfer chlorination. Varying molecular weights of polystyrene-b-poly(2,5-benzophenone)-b-polystyrene were synthesized using the macroinitiators in the atom transfer radical polymerization of styrene. The materials were characterized by gel permeation chromatography, nuclear magnetic resonance, differential scanning calorimetry, and transmission electron microscopy. Applications were explored through dynamic mechanical analysis and the construction of a distributed junction photovoltaic device.

  DOI：

  10.1021/ma0352983

文献信息

• Threefold and chemoselective couplings of triarylbismuths with benzylic chlorides and iodides using palladium catalysis
  作者：Maddali L. N. Rao、Ritesh J. Dhanorkar

  DOI：10.1039/c3ra46672h

  日期：——

  This paper describes the palladium-catalyzed studies on threefold coupling of triarylbismuth reagents with benzylic chlorides and iodides. The optimized protocol conditions are operationally simple, delivering threefold coupling of a variety of triarylbismuths in combination with benzylic chlorides and iodides. The two optimized protocols allowed the synthesis of a diverse range of unsymmetrical diarylmethanes in an efficient manner. As part of this study, chemoselective transformation of benzylic chlorides and iodides was also achieved.

  本文描述了对三芳基铋试剂与苄基氯和碘进行三重偶联的钯催化研究。经过优化的实验条件操作简单，使得多种三芳基铋与苄基氯和碘的三重偶联得以实现。这两种优化的实验方案使得不对称二芳基甲烷的合成变得高效。在本研究的过程中，还实现了苄基氯和碘的化学选择性转化。
• Benzophenone hydrazone derivatives as insecticides
  申请人：NIHON BAYER AGROCHEM K.K.

  公开号：EP0742202A2

  公开（公告）日：1996-11-13

  Summary Of The Invention Novel benzophenonehydrazone derivatives represented by the formula (I): wherein, R1 is halogen; R2 is hydrogen or C1-4 alkyl; R3 is cyano, optically substituted C1-4 alkyl, C2-4 alkenyl, C3-4 alkynyl, C1-4 alkyl-carbonyl or C1-4 alkoxy-thiocarbonyl; R4 is hydrogen, phenyl, optionally substituted C1-6 alkyl, optionally substituted C2-8 alkenyl, -CO-R8, -CO-O-R9 or R5 is hydrogen, formyl, phenyl, optionally substituted C1-8 alkyl, optionally substituted C2-8 alkenyl, optionally substituted C3-8 alkynyl, optionally substituted C1-8 alkyl-carbonyl, optionally substituted C1-6 alkyl-oxalyl, optionally substituted C1-8 alkoxy-carbonyl, optionally substituted C1-8 alkoxy-oxalyl, optionally substituted C3-8 cycloalkyl-carbonyl, optionally substituted C2-8 alkenyl-carbonyl or optionally substituted benzoyl; R6 is hydrogen or halogen; R7 is hydrogen, halogen or C1-2 alkyl, C1-4 alkyl-carbonyl or C1-4 alkoxy-thiocarbonyl; n is 0, 1 or 2, provided that n is 0 when R3 is cyano, C1-4 alkyl-carbonyl or C1-4 alkoxy-thiocarbonyl, is a single bond of Anti form or of Syn form. The benzophenonehydrazone derivatives of the formula (I) have excellent insecticidal activities.

  发明概述 由式(I)代表的新型二苯甲酮腙衍生物： 其中，R1 是卤素；R2 是氢或 C1-4 烷基；R3 是氰基、被光学取代的 C1-4 烷基、C2-4 烯基、C3-4 炔基、C1-4 烷基-羰基或 C1-4 烷氧基-硫代羰基；R4 是氢、苯基、任选取代的 C1-6 烷基、任选取代的 C2-8 烯基、-CO-R8、-CO-O-R9 或 R5 是氢、甲酰基、苯基、任选取代的 C1-8 烷基、任选取代的 C2-8 烯基、任选取代的 C3-8 烷炔基、任选取代的 C1-8 烷基-羰基、任选取代的 C1-6 烷基-氧羰基、任选取代的 C1-8 烷氧基-羰基、任选取代的 C1-8 烷氧基-氧羰基、任选取代的 C3-8 环烷基-羰基、任选取代的 C2-8 烯基-羰基或任选取代的苯甲酰基；R6是氢或卤素；R7是氢、卤素或C1-2烷基、C1-4烷基-羰基或C1-4烷氧基-硫代羰基；n是0、1或2，但当R3是氰基、C1-4烷基-羰基或C1-4烷氧基-硫代羰基时，n为0，是Anti形式或Syn形式的单键。 式（I）的二苯甲酮腙衍生物具有优异的杀虫活性。
• TRIFLUORO METHYLTHIOMETHYL BENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
  申请人：IHARA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP1000933B1

  公开（公告）日：2006-08-02
• US6077866A
  申请人：——

  公开号：US6077866A

  公开（公告）日：2000-06-20
• US6225505B1
  申请人：——

  公开号：US6225505B1

  公开（公告）日：2001-05-01