3β,17β-Dihydroxy-5α-pregnan | 601-08-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β,17β-Dihydroxy-5α-pregnan
• 英文别名: 5α,17α-Pregnan-3β,17β-diol；17α-Ethyl-5α-androstandiol-(3β,17β)；5α.17βH-pregnanediol-(3β.17)；3β.17β-Dihydroxy-10.13-dimethyl-17α-aethyl-5α-gonan；(10S)-3c.17c-Dihydroxy-10r.13c-dimethyl-17t-aethyl-(5tH.8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；5α.17βH-Pregnandiol-(3β.17)；(3S,5S,8R,9S,10S,13S,14S,17S)-17-ethyl-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol
• CAS: 601-08-1
• 化学式: C₂₁H₃₆O₂
• 分子量: 320.516
• InChiKey: HXUOGRLXGBMRIY-FJCZRMHDSA-N

物化性质

• 沸点：
  431.7±18.0 °C(Predicted)
• 密度：
  1.053±0.06 g/cm3(Predicted)
• 熔点：
  181-183 °C

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3β,17β-Dihydroxy-5α-pregnan 在 chromium(VI) oxide 、 copper(II) sulfate 、 溶剂黄146 、 铂 作用下， 140.0 ℃ 、1.33 Pa 条件下， 生成 5α-pregnan-3β-ol
  参考文献：
  名称：

  Facilitating Children's Understanding of Misinterpretation: Explanatory Efforts and Improvements in Perspective Taking

  摘要：

  The authors investigated children's understanding of how mistaken beliefs can arise through misinterpretation of ambiguous information. Children (N = 91), aged 4 to 5 years, were given pre- and posttests on their ability to infer a puppet's interpretation of a restricted-view drawing after the puppet had been led to an erroneous expectation about the drawing's identity. Before the posttest, the children received either self-explanation training or other-explanation training in which they explained the source of their own or a puppet's misinterpretations of drawings; a control group received no training. The children who received training improved from pre- to posttest, and those who had practiced explaining misinterpretations by referring to previously viewed pictures or to features of a target picture showed the greatest improvement. These results indicate that learning to explain misinterpretations can help children recognize situations in which misinterpretations are likely to occur.

  DOI：

  10.1080/00221320209598673
• 作为产物：
  描述：

  3β-Acetoxy-5α,17α-pregnan-17β-ol 在 1,4-二氧六环 、 氢氧化钾 作用下， 生成 3β,17β-Dihydroxy-5α-pregnan
  参考文献：
  名称：

  关于肾上腺皮质成分及相关物质。两种异构的20，21-氧基-allopregnan-二醇（3β，17β）的制备及反应; 两个同素异戊二烯四元醇与相应的同素-孕三胞胎的构型连接

  摘要：

  DOI：

  10.1002/hlca.19470300702

文献信息

• Ouannes,C. et al., Bulletin de la Societe Chimique de France, 1964, p. 776 - 782
  作者：Ouannes,C. et al.

  DOI：——

  日期：——
• Dvolaitzky,M.; Jacques,J., Bulletin de la Societe Chimique de France, 1963, p. 2793 - 2800
  作者：Dvolaitzky,M.、Jacques,J.

  DOI：——

  日期：——
• DE643978
  申请人：——

  公开号：——

  公开（公告）日：——
• Sexualhormone X. Herstellung des 17-Methyl-testosterons und anderer Androsten- und Androstanderivate. Zusammenhänge zwischen chemischer Konstitution und männlicher Hormonwirkung
  作者：L. Ruzicka、M. W. Goldberg、H. R. Rosenberg

  DOI：10.1002/hlca.193501801203

  日期：——
• Reduction Studies on Unsaturated Steroids
  作者：Eugene P. Oliveto、Lois Weber、E. B. Hershberg

  DOI：10.1021/ja01646a067

  日期：1954.9