5α-pregnan-3β-ol | 4352-06-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5α-pregnan-3β-ol
• 英文别名: 3β-Hydroxy-5α-pregnan；5a-Pregnane-3b-ol；(3S,5S,8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 4352-06-1
• 化学式: C₂₁H₃₆O
• 分子量: 304.516
• InChiKey: CEBZORSAHLSRQW-DDYSHWNRSA-N

物化性质

• 熔点：
  137-138 °C
• 沸点：
  394.7±10.0 °C(Predicted)
• 密度：
  0.986±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5α-pregnan-3β-ol 在 chromium(VI) oxide 、 溶剂黄146 作用下， 以 氯仿 为溶剂， 生成 3α-Methoxy-5α-pregnane
  参考文献：
  名称：

  梨形肉球菌生物碱C

  摘要：

  摘要 早先从梨形肉球菌中分离的生物碱 C 已被证明是 3 a -甲氧基-20 a -二甲氨基-孕-5-烯。

  DOI：

  10.1016/s0031-9422(00)94070-6
• 作为产物：
  描述：

  别孕烯醇酮 在 sodium hydroxide 、 一水合肼 、 三乙二醇 作用下， 生成 5α-pregnan-3β-ol
  参考文献：
  名称：

  改良 Wolff--Kishner 法还原类固醇酮和其他羰基化合物

  摘要：

  根据Dutcher 和Wintersteiner2，在通常条件下通过Wow-Kishner 方法还原C3-类固醇酮主要产生相应的Cs-差向异构甲醇和少量预期的Cs-亚甲基产物。在α,P-不饱和酮、胆甾酮的情况下，还原遵循更复杂的过程。除了差向异构不饱和甲醇和少量正常产物A4-胆甾醇外，还分离出饱和甲醇、α-粪甾醇和P-胆甾醇。作者指出，异常还原可以通过以下假设来解释：腙或缩氨基脲部分水解为游离酮，然后被醇钠还原为仲醇。然而，这些可能性被修改后的 WolffKishner red ~ ction 消除，~ , ~ 其中水在加热期间蒸发。此外，该反应中使用过量的水合肼应将再生酮的浓度保持在较低水平。 2 事实上，迄今为止研究的所有 C3-甾体酮都通过改性的 Wolff-Kish20-二酮孕烷得到了正常的 C3-亚甲基化合物(I) 得到在 152-153' 熔化的还原产物，其中两个酮基中的一个未

  DOI：

  10.1021/ja01178a008

文献信息

• [EN] USE OF STEROID-DERIVED PHARMACEUTICAL COMPOSITIONS FOR TREATING DISORDERS RELATING TO PATHOLOGICAL PROCESSES IN LIPID RAFTS<br/>[FR] UTILISATION DE COMPOSITIONS PHARMACEUTIQUES DERIVEES DE STEROIDES POUR LE TRAITEMENT DE TROUBLES ASSOCIES A DES PROCESSUS PATHOLOGIQUES DANS LES RADEAUX LIPIDIQUES
  申请人：JADOLABS GMBH

  公开号：WO2006002907A1

  公开（公告）日：2006-01-12

  The present invention relates to the use of specific steroid derivatives in the preparation of medicaments for the treatment or prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.

  本发明涉及在制备用于治疗或预防和/或改善与脂质浮 rafts 中的病理过程相关的疾病的药物时使用特定类固醇衍生物。
• Separation and characterization of the alkaloids of sarcococca pruniformis
  作者：J.M. Kohli、A. Zaman、A.R. Kidwai

  DOI：10.1016/0040-4020(67)80030-9

  日期：——

  Two new steroidal alkaloids (A and B) isolated from Sarcococca pruniformis have been identified as 3α-dimethylamino-20α-methylacetylamino-5α-pregnane (I) and 3α-dimethylamino-20-methylacetyl amino-pregn-5-ene (II).

  从桔梗小球菌中分离出的两种新的甾体生物碱（A和B）已被鉴定为3α-二甲基氨基-20α-甲基乙酰氨基-5α-孕烯（I）和3α-二甲基氨基-20-甲基乙酰氨基-孕烯5-烯（II）。
• Pharmaceutical composition comprising 3-beta-hydroxy-5-alpha-pregnan-20-one with improved storage and solubility properties
  申请人：ASARINA PHARMA AB

  公开号：US11534446B2

  公开（公告）日：2022-12-27

  It is provided a pharmaceutical composition comprising 3-beta-hydroxy-5-alpha-pregnan-20-one, at least one sterol or an ester thereof and a mixture of acylglycerols with a solid fat content of less than 25% at 25° C. and 0% at 37° C. In addition it is provided a method for preparing the pharmaceutical composition.

  本发明提供了一种药物组合物，它包含 3-beta-羟基-5-α-孕甾-20-酮、至少一种甾醇或其酯以及酰基甘油混合物，其固体脂肪含量在 25° C 时低于 25%，在 37° C 时低于 0%。
• Ercoli; de Ruggieri, Il Farmaco, scienza e tecnica, 1952, vol. 7, p. 11,19
  作者：Ercoli、de Ruggieri

  DOI：——

  日期：——
• Facilitating Children's Understanding of Misinterpretation: Explanatory Efforts and Improvements in Perspective Taking
  作者：Bradford H. Pillow、Clay Mash、Samuel Aloian、Valerie Hill

  DOI：10.1080/00221320209598673

  日期：2002.6

  The authors investigated children's understanding of how mistaken beliefs can arise through misinterpretation of ambiguous information. Children (N = 91), aged 4 to 5 years, were given pre- and posttests on their ability to infer a puppet's interpretation of a restricted-view drawing after the puppet had been led to an erroneous expectation about the drawing's identity. Before the posttest, the children received either self-explanation training or other-explanation training in which they explained the source of their own or a puppet's misinterpretations of drawings; a control group received no training. The children who received training improved from pre- to posttest, and those who had practiced explaining misinterpretations by referring to previously viewed pictures or to features of a target picture showed the greatest improvement. These results indicate that learning to explain misinterpretations can help children recognize situations in which misinterpretations are likely to occur.