5α-pregnanol-(3α) | 13164-12-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5α-pregnanol-(3α)
• 英文别名: (10S)-3t-Hydroxy-10r.13c-dimethyl-17c-aethyl-(5tH.8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；3α-Hydroxy-10.13-dimethyl-17β-aethyl-5α-gonan；5a-Pregnan-3a-ol；(3R,5S,8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 13164-12-0
• 化学式: C₂₁H₃₆O
• 分子量: 304.516
• InChiKey: CEBZORSAHLSRQW-PECKBWEZSA-N

物化性质

• 沸点：
  394.7±10.0 °C(Predicted)
• 密度：
  0.986±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5α-pregnan-3β-ol 在 chromium(VI) oxide 、 aluminum isopropoxide 、 溶剂黄146 、 异丙醇 作用下， 生成 5α-pregnanol-(3α)
  参考文献：
  名称：

  Facilitating Children's Understanding of Misinterpretation: Explanatory Efforts and Improvements in Perspective Taking

  摘要：

  The authors investigated children's understanding of how mistaken beliefs can arise through misinterpretation of ambiguous information. Children (N = 91), aged 4 to 5 years, were given pre- and posttests on their ability to infer a puppet's interpretation of a restricted-view drawing after the puppet had been led to an erroneous expectation about the drawing's identity. Before the posttest, the children received either self-explanation training or other-explanation training in which they explained the source of their own or a puppet's misinterpretations of drawings; a control group received no training. The children who received training improved from pre- to posttest, and those who had practiced explaining misinterpretations by referring to previously viewed pictures or to features of a target picture showed the greatest improvement. These results indicate that learning to explain misinterpretations can help children recognize situations in which misinterpretations are likely to occur.

  DOI：

  10.1080/00221320209598673

文献信息

• [EN] NEUROACTIVE STEROIDS AND METHODS OF PREPARATION<br/>[FR] STÉROÏDES NEUROACTIFS ET PROCÉDÉS DE PRÉPARATION
  申请人：DRAWBRIDGE PHARMACEUTICALS PTY LTD

  公开号：WO2020006596A1

  公开（公告）日：2020-01-09

  Disclosed are neuroactive steroid anaesthetic agents, methods for their preparation and compositions comprising the same. The invention provides scaled up and/or GMP methods for preparing neuroactive steroids, such as alfaxalone, alfadolone and alfadolone acetate.

  揭示了神经活性类固醇麻醉剂、其制备方法以及含有它们的组合物。该发明提供了用于制备神经活性类固醇（如阿法索醇、阿法醇和阿法醇醋酸酯）的放大和/或GMP方法。
• 3-beta-hydroxy-5-alpha-pregnan-20-one for use in medical treatment
  申请人：ASARINA PHARMA AB

  公开号：US11026954B2

  公开（公告）日：2021-06-08

  The present invention provides the steroid compound 3beta-hydroxy-5alpha-pregnan-20-one for use in treatment of Tourette's syndrome, obsessive compulsive disorder and/or gambling disorder, as well as methods for treating said disorders and pharmaceutical compositions for use in treatment of said disorders.

  本发明提供了用于治疗妥瑞症、强迫症和/或赌博障碍的类固醇化合物 3beta-羟基-5α-孕甾-20-酮，以及治疗上述障碍的方法和用于治疗上述障碍的药物组合物。
• METHODS AND COMPOSITIONS FOR INDUCING SLEEP
  申请人：COCENSYS, INC.

  公开号：EP0701444A1

  公开（公告）日：1996-03-20
• ALLOPREGNANOLONE IN A METHOD FOR ENHANCING NEUROLOGICAL FUNCTION (ALZHEIMER DISEASE)
  申请人：University Of Southern California

  公开号：EP2167098A1

  公开（公告）日：2010-03-31
• NEUROACTIVE STEROIDS AND METHODS OF PREPARATION
  申请人：Drawbridge Pharmaceuticals Pty Ltd

  公开号：EP3818068A1

  公开（公告）日：2021-05-12