2-methyltetradecan-1-ol | 38231-91-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methyltetradecan-1-ol
• CAS: 38231-91-3
• 化学式: C₁₅H₃₂O
• mdl: MFCD21671594
• 分子量: 228.418
• InChiKey: CGTBUYCHHZHYBU-UHFFFAOYSA-N

物化性质

• 熔点：
  32.0-32.2 °C
• 沸点：
  134 °C(Press: 2 Torr)
• 密度：
  0.833±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  16
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险性防范说明：
  P264,P280,P302+P352,P305+P351+P338,P332+P313,P337+P313,P362
• 危险性描述：
  H315,H319
• 储存条件：
  2-8°C，干燥

反应信息

• 作为反应物：
  描述：

  2-methyltetradecan-1-ol 在 磷化氢 、 碘 作用下， 生成 1-iodo-2-methyl-tetradecane
  参考文献：
  名称：

  Asano et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1950, vol. 70, p. 202,207

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基肉豆蔻酸 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 2-methyltetradecan-1-ol
  参考文献：
  名称：

  Enantioselective transesterifications of 2-methyl-1-alcohols catalysed by lipases from Pseudomonas

  摘要：

  Racemic beta-methyl-2-thiophenepropanol was resolved (E approximate to 200) via transesterification catalysed by lipase from Pseudomonas fluorescens using an excess of vinyl acetate in chloroform at an initial water activity: a(W) = 0.32. When trying to resolve rac-2-methyl-1-alkanols more modest E-values were obtained (E approximate to 10) and were of the same order of magnitude irrespective of substrate chainlength, water activity, immobilization, acyl donor or other Pseudomonas derived lipases. However, the reaction rates are affected by variations of these parameters. Both the rates and E-values were influenced by the nature of the solvent.

  DOI：

  10.1016/s0957-4166(00)86227-8

文献信息

• [EN] PYRROLE DERIVATIVES AS ACC INHIBITORS<br/>[FR] DÉRIVÉS DE PYRROLE UTILISÉS EN TANT QU'INHIBITEURS D'ACC
  申请人：ALMIRALL SA

  公开号：WO2020245291A1

  公开（公告）日：2020-12-10

  Novel pyrrole derivatives of Formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Acetyl-CoA carboxylase (ACC).

  公开了式（I）的新吡咯衍生物；以及它们的制备方法，包括它们的药物组合物和它们作为乙酰辅酶A羧化酶（ACC）抑制剂在治疗中的用途。
• Lack of the neighboring group rate effect in solvolytic reactions that proceed via participation
  作者：Sandra Jurić、Olga Kronja

  DOI：10.1002/poc.1290

  日期：2008.2

  In order to investigate the influence of solvent polarity on the rate effect of double bonds in reactions that proceed via an extended π-participation mechanism, the solvolysis rates (kU) of the benzyl chloride derivative 1 and tertiary chloride 2 that have doubly unsaturated side chains were measured in absolute ethanol, 80% v/v. aq. ethanol and 97% wt. aq. trifluoroethanol. The rates of the corresponding

  为了调查关于双键的速率影响溶剂极性的反应，其通过扩展继续影响π -participation机构，所述溶剂分解速率（ķ ü的苄基氯衍生物）1和叔氯化物2具有双不饱和侧在80％v / v的无水乙醇中测量链。水 乙醇和97％wt。水 三氟乙醇。相应的饱和类似物1S和2S（k S）的比率是在80％水溶液中测量的。乙醇和97％wt。水 三氟乙醇，而纯乙醇中的那些是根据LFER方程log k  =  s计算的f（E f  + N f）。在具有中等电离能力的溶剂（乙醇和80％乙醇水溶液）中，可以获得预期的速率影响（k U / k S > 1），而在具有高电离能力的溶剂（2,2,2-三氟乙醇）中则没有观察率效应（ķ û / ķ小号≈1），这表明在ķ小号处理过渡状态的溶剂化是非常重要的，而在ķ Δ过程中的C的断裂Cl键不会明显在过渡开发状态和溶剂作用是微不足道的。版权所有©2007 John Wiley＆Sons，Ltd
• ORGANIC ELECTROLUMINESCENT DEVICE AND DISPLAY MEDIUM
  申请人：IMAI Akira

  公开号：US20100276672A1

  公开（公告）日：2010-11-04

  An organic electroluminescent device includes: a pair of electrodes including a positive electrode and a negative electrode, at least one of the electrodes being transparent or semi-transparent; and an organic compound layer including one or more layers interposed between the pair of electrodes, at least one layer included in the organic compound layer containing one or more compounds represented by the following formula (I): in formula (I), R 1 s each independently representing a linear alkyl, linear alkoxy, branched alkyl, or branched alkoxy group having from 3 to 20 carbon atoms; and R 2 s each independently representing a hydrogen atom, a linear alkyl group having from 1 to 20 carbon atoms, a linear alkoxy group having from 1 to 20 carbon atoms, a branched alkyl group having from 3 to 20 carbon atoms, or a branched alkoxy group having from 3 to 20 carbon atoms.

  一种有机电致发光器件包括：一对电极，包括一个正电极和一个负电极，其中至少一个电极是透明或半透明的；以及一个有机化合物层，包括夹在一对电极之间的一个或多个层，有机化合物层中至少包含一个含有一个或多个以下式(I)所代表的化合物的层：在式(I)中，R1分别独立地表示具有3至20个碳原子的直链烷基，直链烷氧基，支链烷基或支链烷氧基；R2分别独立地表示氢原子，具有1至20个碳原子的直链烷基，具有1至20个碳原子的直链烷氧基，具有3至20个碳原子的支链烷基，或具有3至20个碳原子的支链烷氧基。
• Reductive Opening of Oxetanes Catalyzed by Frustrated Lewis Pairs: Unexpected Aryl Migration via Neighboring Group Participation
  作者：Luning Tang、Yu Zang、Wengang Guo、Zhengyu Han、Hai Huang、Jianwei Sun

  DOI：10.1021/acs.orglett.2c01088

  日期：2022.5.6

  B(C6F5)3 was found to catalyze an unusual double reduction of oxetanes by hydrosilane with aryl migration via neighboring group participation. Control experiments suggested that the phenonium ion serves as the key intermediate. Minor modification of this protocol also led to simple hydrosilylative opening of oxetanes.

  发现B(C 6 F 5 ) 3催化氢硅烷对氧杂环丁烷的异常双重还原，其中芳基迁移通过相邻基团参与。对照实验表明铼离子是关键的中间体。该协议的微小修改也导致了氧杂环丁烷的简单氢化开环。
• Antiretroviral furan ketones
  申请人：Merrell Dow Pharmaceuticals

  公开号：US04980371A1

  公开（公告）日：1990-12-25

  Furan ketone derivatives thereof having antiretrovirus activity and effective in a method of treatment of a retrovirus infection, have the formula ##STR1## wherein Y is a bond, oxygen or divalent sulfur; n is 0 or 1; R is a straight or branched C.sub.8-20 alkyl chain or a straight or branched C.sub.8-20 alkenyl chain having from 1 to 4 double bonds; and R.sub.1 is C.sub.1-6 alkyl.

  具有抗逆转录病毒活性并在逆转录病毒感染的治疗方法中有效的呋喃酮衍生物具有以下式子：##STR1## 其中，Y是键，氧或二价硫；n为0或1；R是直链或支链C.sub.8-20烷基链或具有1至4个双键的直链或支链C.sub.8-20烯基链；R.sub.1为C.sub.1-6烷基。