2-[(2-carboxyphenyl)diazenyl]benzoic acid | 635-54-1

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: 2-[(2-carboxyphenyl)diazenyl]benzoic acid
• 英文别名: 2,2'-(diazene-1,2-diyl)dibenzoic acid；azobenzoic acid
• CAS: 635-54-1
• 化学式: C₁₄H₁₀N₂O₄
• 分子量: 270.244
• InChiKey: OOGKXQSCDZDEFV-FOCLMDBBSA-N

物化性质

• 熔点：
  238-239 °C
• 沸点：
  533.9±35.0 °C(Predicted)
• 密度：
  1.35±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.32
• 氢给体数：
  2.0
• 氢受体数：
  4.0

安全信息

• 海关编码：
  2927000090
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  2,6-二叔丁基-4-甲基苯酚 、 2-[(2-carboxyphenyl)diazenyl]benzoic acid 以 甲醇 、 水 为溶剂， 生成 2,2'-dicarboxyhydrazobenzene
  参考文献：
  名称：

  Immunochemical assay method

  摘要：

  半抗原和抗原衍生物通过偶氮键与蛋白质偶联，形成共轭材料。将这种共轭物注射到实验动物体内，以产生对原始半抗原和抗原衍生物有用的抗体，用于免疫化学测定。免疫化学测定方法包括放射免疫测定和荧光方法。

  公开号：

  US04097586A1
• 作为产物：
  描述：

  对氨基苯甲酸 在 盐酸 作用下， 以 甲醇 为溶剂， 生成 2-[(2-carboxyphenyl)diazenyl]benzoic acid
  参考文献：
  名称：

  Immunochemical assay method

  摘要：

  半抗原和抗原衍生物通过偶氮键与蛋白质偶联，形成共轭材料。将这种共轭物注射到实验动物体内，以产生对原始半抗原和抗原衍生物有用的抗体，用于免疫化学测定。免疫化学测定方法包括放射免疫测定和荧光方法。

  公开号：

  US04097586A1

文献信息

• A three-dimensional Zn^IIcoordination framework: poly[[μ₂-(<i>E</i>)-1,2-bis(pyridin-4-yl)ethene][μ₄-(<i>E</i>)-2,2′-(diazene-1,2-diyl)dibenzoato][μ₂-(<i>E</i>)-2,2′-(diazene-1,2-diyl)dibenzoato]dizinc(II)]
  作者：Cai-Xia Yu、Feng Zhao、Min Zhou、Dan-Feng Zhi、Lei-Lei Liu

  DOI：10.1107/s2053229614001077

  日期：2014.3.1

  In the title coordination polymer, [Zn₂(C₁₄H₈N₂O₄)₂(C₁₂H₁₀N₂)]_n, the asymmetric unit contains one Zn^IIcation, two halves of 2,2′-(diazene-1,2-diyl)dibenzoate anions (denotedL²⁻) and half of a 1,2-bis(pyridin-4-yl)ethene ligand (denoted bpe). The three ligands lie across crystallographic inversion centres. Each Zn^IIcentre is four-coordinated by three O atoms of bridging carboxylate groups from threeL²⁻ligands and by one N atom from a bpe ligand, forming a tetrahedral coordination geometry. Two Zn^IIatoms are bridged by two carboxylate groups ofL²⁻ligands, generating a [Zn₂(CO₂)₂] ring. Each loop serves as a fourfold node, which links its four equivalent nodesviathe sharing of fourL²⁻ligands to form a two-dimensional [Zn₂L₄]_nnet. These nets are separated by bpe ligands acting as spacers, producing a three-dimensional framework with a 4⁶6⁴topology. Powder X-ray diffraction and solid-state photoluminescence were also measured.

  在标题配位聚合物[Zn2(C14H8N2O4)2(C12H10N2)]n 中，不对称单元包含一个 ZnIIcation、两半 2,2′-（重氮-1,2-二基）二苯甲酸阴离子（表示为 L2-）和一半 1,2-双（吡啶-4-基）乙烯配体（表示为 bpe）。这三种配体横跨晶体反转中心。每个 ZnII 中心与来自三个 L2 配体的桥接羧酸基团的三个 O 原子和来自一个 bpe 配体的一个 N 原子四配位，形成一个四面体配位几何。两个 ZnII 原子被 L2 配体的两个羧基桥接，形成一个 [Zn2(CO2)2] 环。每个环作为一个四重节点，将其四个等效节点与共享的四个 L2 配体连接起来，形成一个二维[Zn2L4]网。这些网由作为间隔物的 bpe 配体隔开，形成一个具有 4664 拓扑结构的三维框架。此外，还对粉末 X 射线衍射和固态光致发光进行了测量。
• Structure−Reactivity Correlation of Anilines in Acetic Acid
  作者：Chockalingam Karunakaran、Ramasamy Kamalam

  DOI：10.1021/jo0158433

  日期：2002.2.1

  The oxidation of aniline in glacial acetic acid with percarbonate, a dry carrier of hydrogen peroxide, is a second-order reaction conforming to the isokinetic relationship. The hitherto followed method of correlation of the reaction rates in terms of the structure-reactivity relationships is unsatisfactory and erroneous. But the reaction rates of molecular anilines, obtained for the first time, conform

  冰醋酸中苯胺与过碳酸盐（过氧化氢的干燥载体）的氧化是符合等动力学关系的二级反应。迄今为止按照结构-反应性关系进行反应速率相关的跟踪方法是不令人满意的并且是错误的。但是首次获得的分子苯胺的反应速率符合结构-反应性关系。
• Radioimmune method of assaying quantitatively for a hapten
  申请人：Biological Developments, Inc.

  公开号：US03940475A1

  公开（公告）日：1976-02-24

  A radioimmune method of assaying quantitatively for a hapten comprising contacting an aqueous sample containing the hapten under assay, a known quantity of a radioactively labeled marker which incorporates a hapten homologous to the hapten under assay, and an insolubilized antibody specific for the hapten under assay to competitively bind part of said labeled hapten and the hapten contained in said sample to the antibody; incubating the foregoing mixture until a two-phase system is produced comprising an insoluble or solid phase and an aqueous phase, and measuring the radioactivity of at least one of said two phases, the value of said radioactivity being a function of the concentration in said sample of the hapten under assay.

  一种放射免疫测定法，用于定量测定半抗原，包括将待测含有半抗原的水样与已知量的含有与待测半抗原同源的半抗原的放射性标记物和特异于待测半抗原的抗体的不溶化合物接触，使标记的半抗原的一部分和样品中含有的半抗原竞争性地与抗体结合；孵育上述混合物直至产生包含不溶性或固体相和水相的两相系统，并测量至少其中一相的放射性，所述放射性的值是样品中待测半抗原的浓度的函数。
• ORGANIC/INORGANIC HYBRID NANOPARTICULATES MADE FROM IRON CARBOXYLATES
  申请人：Horcajada-Cortes Patricia

  公开号：US20100209354A1

  公开（公告）日：2010-08-19

  The invention relates to nanoparticles made from organometallic hybrid materials made from iron carboxylates, used for example as contrast agents. The particles can also be used for the encapsulation and vectoring of molecules of interest such as active3 pharmaceutical agents, cosmetically interesting compounds and markers. Apart from the intrinsic properties thereof for imaging, said nanoparticles give good results in terms of capacity for loading with medicaments and in biocompatibility.

  该发明涉及由铁羧酸盐制成的有机金属混合材料制成的纳米颗粒，例如用作对比剂。这些颗粒还可用于封装和导向感兴趣的分子，如活性药物、具有化妆品特性的化合物和标记物。除了其成像的固有特性外，这些纳米颗粒在药物载荷能力和生物相容性方面也表现出良好的结果。
• REDUCIBLE POROUS CRYSTALLINE HYBRID SOLID FOR THE SEPARATION OF MIXTURES OF MOLECULES HAVING DIFFERENT DEGREES AND/OR A DIFFERENT NUMBER OF UNSATURATIONS
  申请人：Serre Christian

  公开号：US20110172412A1

  公开（公告）日：2011-07-14

  The present invention relates to reducible porous crystalline solids, constituted of a metal-organic framework (MOF), for the separation of mixtures of molecules having different unsaturation degrees and/or a different number of unsaturations with a selectivity that can be adjusted by controlling the reduction of the MOF. The MOF solids of the present invention, after reduction, have a strong affinity for molecules containing at least one unsaturation. They can be used in various separation processes, especially those relating to hydrocarbons.

  本发明涉及可还原的多孔晶体固体，由金属有机框架（MOF）构成，用于分离具有不同不饱和度和/或不同不饱和度数量的分子混合物，并且可以通过控制MOF的还原来调节选择性。本发明的MOF固体在还原后对至少含有一个不饱和度的分子具有很强的亲和力。它们可以用于各种分离过程，特别是与烃有关的过程。