(4bR,8aS,9S)-3,7-dimethoxy-11-methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-4,6-diol | 107989-08-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (4bR,8aS,9S)-3,7-dimethoxy-11-methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-4,6-diol
• 英文别名: 6β-hydroxy-7,8-dihydrosinomenine；ent-3,7α-dimethoxy-17-methyl-morphinane-4,6α-diol；ent-3,7α-Dimethoxy-17-methyl-morphinan-4,6α-diol；Dihydrosinomeninol-B
• CAS: 107989-08-2；108210-75-9；108210-76-0
• 化学式: C₁₉H₂₇NO₄
• 分子量: 333.428
• InChiKey: PHUHOTJSRRFTRH-OBQODUIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.68
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  62.16
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (4bR,8aS,9S)-3,7-dimethoxy-11-methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-4,6-diol 在 甲醇 、 silver nitrate 作用下， 生成 N-(9-hydroxy-1,2,3-trimethoxy-5,6,7,7b,8,9,10,10a-octahydro-benzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)-acetamide 、 3,7,3',7'-Tetramethoxy-17,17'-dimethyl-[1,1']bimorphinanyl-4,6,4',6'-tetraol
  参考文献：
  名称：

  Goto et al., Journal of the Agricultural Chemical Society of Japan, 1955, vol. 19, p. 1,3

  摘要：

  DOI：
• 作为产物：
  描述：

  6β-hydroxysinomenine 在 铂 作用下， 生成 (4bR,8aS,9S)-3,7-dimethoxy-11-methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-4,6-diol
  参考文献：
  名称：

  Liquid–liquid phase separation and crystallization behavior of poly(ethylene terephthalate)/poly(ether imide) blend

  摘要：

  The liquid-liquid (L-L) phase separation and crystallization behavior of poly(ethylene terephthalate) (PET)/poly(ether imide) (PEI) blend were investigated with optical microscopy, light scattering, and small angle X-ray scattering (SAXS). The thermal analysis showed that the concentration fluctuation between separated phases was controllable by changing the time spent for demixing before crystallization. The L-L phase-separated specimens at 130 C for various time periods were subjected to a temperature-jump of 180 C for the isothermal crystallization and then effects of L-L phase separation on crystallization were investigated. The crystal growth rate decreased with increasing L-L phase-separated time (t(s)). The slow crystallization for a long t(s) implied that the growth path of crystals was highly distorted by the rearrangement of the spinodal domains associated with coarsening. The characteristic morphological parameters at the lamellar level were determined by the correlation function analysis on the SAXS data. The blend had a larger amorphous layer thickness than the pure PET, indicating that PEI molecules in the PET-rich phase were incorporated into the interlamellar regions during crystallization. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0032-3861(02)00054-x

文献信息

• Sinomenine derivatives with embedment of nitrogen-containing heterocycles exhibiting potent TNF-αinhibitory activity
  作者：Meng Wang、LiYan Ma、YangTong Lou、Chao Bian、TingTing Zhou、HaiBin Zhou、HongZe Liao、Zhao Ma、DongSheng Yin、AiZhong Chen、ShaoZhong Wang、ZhenYu Yang、Bing Sun、ZhuJun Yao

  DOI：10.1007/s11426-012-4588-8

  日期：2012.12

  Inhibitory effect on tumor necrosis factor-α (TNF-α) production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work. Several new sinomenine derivatives having chlorophenyl substituent have been found to exhibit much more potent TNF-α inhibitory activity than natural sinomenine and other derivatives.

  本研究探讨了含有小型药物类氮杂环基团的盐酸缬草碱衍生物对肿瘤坏死因子-α（TNF-α）产生的抑制作用。发现几种具有氯苯基取代基的新型盐酸缬草碱衍生物展现出比天然盐酸缬草碱及其他衍生物更强的TNF-α抑制活性。