2-methylene-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-9,10-anthraquinone

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 2-methylene-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-9,10-anthraquinone
• 英文别名: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxymethyl]anthracene-9,10-dione
• 化学式: C₂₁H₂₂O₆
• 分子量: 370.402
• InChiKey: JTBBTIRMZIFRAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-羟甲基蒽醌 在 四溴化碳 、 sodium hydride 、 三苯基膦 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.5h， 生成 2-methylene-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-9,10-anthraquinone
  参考文献：
  名称：

  Anthraquinone derivatives as a new family of protein photocleavers

  摘要：

  Certain anthraquitiones, which are present in many biologically important natural products, effectively and randomly cleaved proteins (BSA or Lyso) during photoirradiation using a long wavelength UV light without any further additives. It was also found that this ability could be improved by the attachment of a suitable substituent into the anthraquinone core skeleton. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.137

文献信息

• Anthraquinone derivatives as a new family of protein photocleavers
  作者：Akane Suzuki、Masashi Hasegawa、Maiko Ishii、Shuichi Matsumura、Kazunobu Toshima

  DOI：10.1016/j.bmcl.2005.05.137

  日期：2005.10

  Certain anthraquitiones, which are present in many biologically important natural products, effectively and randomly cleaved proteins (BSA or Lyso) during photoirradiation using a long wavelength UV light without any further additives. It was also found that this ability could be improved by the attachment of a suitable substituent into the anthraquinone core skeleton. (c) 2005 Elsevier Ltd. All rights reserved.