2-(4-溴苯基)-4-甲基吡啶 | 656257-50-0

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(4-溴苯基)-4-甲基吡啶
• 英文名称: 2-(4-bromophenyl)-4-methylpyridine
• CAS: 656257-50-0
• 化学式: C₁₂H₁₀BrN
• 分子量: 248.122
• InChiKey: DEGAQWXCUKVJBR-UHFFFAOYSA-N

物化性质

• 沸点：
  333.7±27.0 °C(Predicted)
• 密度：
  1.375±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-溴苯基)-4-甲基吡啶 在 哌啶 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  [EN] COMPOUNDS
  [FR] COMPOSES

  摘要：

  公开号：

  WO2004013134A3
• 作为产物：
  描述：

  2-溴-4-甲基吡啶 、 4-溴苯硼酸 在 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 15.0h， 以80%的产率得到2-(4-溴苯基)-4-甲基吡啶
  参考文献：
  名称：

  一种黄绿光苯基吡啶铱配合物及其制备方法和应用

  摘要：

  本发明涉及一种黄绿光苯基吡啶铱配合物，该配合物具有如下结构式其中，R1可独立的为甲基、乙基、叔丁基或异丙基等，R2可独立的为3,5‑二(三氟甲基)苯基、3,5‑二氟苯基、苯基、4‑氟苯基或4‑三氟甲基苯基，辅助配体可独立的为2‑(3‑(三氟甲基)‑1H‑1,2,4‑三唑‑5‑基)吡啶、吡啶‑2‑甲酸、乙酰丙酮。发明黄绿光铱(III)配合物具有溶解性好，黄绿光发射等特性，可以用作电致发光磷光材料应用于湿法有机电致发光器件。

  公开号：

  CN108467412A

文献信息

• [EN] 2-PHENYLPYRIDIN-4-YL DERIVATIVES AS ALK5 INHIBITORS<br/>[FR] DERIVES DE C2-PHENYLPYRIDINE-4-YL EN TANT QU'INHIBITEURS D'ALK5
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004013135A1

  公开（公告）日：2004-02-12

  This invention relates to novel 2-phenylpyridin-4-yl heterocyclyl derivatives which are inhibitors of the transforming growth factor, ('TGF')-ß signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ('ALK')-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  本发明涉及一类新颖的2-苯基吡啶-4-基杂环衍生物，这些衍生物是转化生长因子('TGF')-β信号通路的抑制剂，特别是TGF-β I型或激活素样激酶('ALK')-5受体介导的smad2或smad3磷酸化的抑制剂，以及这些衍生物的制备方法和在医学上的应用，特别是在治疗和预防由该通路介导的疾病状态方面的应用。
• 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors
  申请人：Dodic Nerina

  公开号：US20050245520A1

  公开（公告）日：2005-11-03

  This invention relates to novel 2-phenylpyridin-4-yl heterocyclyl derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  本发明涉及新型的2-苯基吡啶-4-基杂环基衍生物，其是转化生长因子（“TGF”）-β信号通路的抑制剂，特别是通过TGF-β type I或激活素样激酶（“ALK”）-5受体对smad2或smad3的磷酸化，本发明还涉及其制备方法以及在医学上的使用，具体用于治疗和预防由该通路介导的疾病状态。
• Compounds
  申请人：Dodic Nerina

  公开号：US20060004051A1

  公开（公告）日：2006-01-05

  The invention relates to novel aminothiazole derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  本发明涉及一种新型的氨基噻唑衍生物，该衍生物是转化生长因子（“TGF”）-β信号通路的抑制剂，特别是抑制TGF-β类型I或类激活素样激酶（“ALK”）-5受体对smad2或smad3的磷酸化，以及该衍生物的制备方法和在医学上的应用，具体地用于治疗和预防由该通路介导的疾病状态。
• ANTHRACENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT USING THE SAME
  申请人：JNC CORPORATION

  公开号：US20150014671A1

  公开（公告）日：2015-01-15

  This organic electroluminescent element is manufactured by using an anthracene derivative having a pyridyl aryl group substituted with an alkyl represented by formula (1) as an electron transport material, and satisfies characteristics such as the following in an adequate and well-balanced manner: improves the external quantum efficiency of the light-emitting element, which is generally required by the electron transport material; reduces the drive voltage of the light-emitting element; and increases the life of the element. (In formula (1), Ar is a divalent or trivalent benzene or naphthalene; R is hydrogen or an alkyl with a carbon number of 1 to 6, but all of the Rs never simultaneously form hydrogen; and R 1 to R 4 are, individually, hydrogen, an alkyl with a carbon number of 1 to 6, a cycloalkyl with a carbon number of 3 to 6, or an aryl with a carbon number of 6 to 20.)

  这种有机电致发光元件是通过使用一个含有吡啶基芳基取代的烷基的蒽衍生物作为电子传输材料来制造的，它以适当且平衡的方式满足以下特性：提高通常由电子传输材料要求的发光元件的外部量子效率；降低发光元件的驱动电压；并延长元件的使用寿命。（在公式（1）中，Ar是二价或三价苯或萘；R是氢或碳数为1到6的烷基，但所有的R从不同时形成氢；R1到R4分别是氢，碳数为1到6的烷基，碳数为3到6的环烷基或碳数为6到20的芳基。）
• Solution-processable high-efficiency bis(trifluoromethyl)phenyl functionalized phosphorescent neutral iridium(III) complex for greenish yellow electroluminescence
  作者：Hongxin Li、Peng Tao、Yanan Xu、Xinwen Zhang、Shujuan Liu、Qiang Zhao

  DOI：10.1016/j.tetlet.2018.03.073

  日期：2018.5

  A novel and highly efficient bis(trifluoromethyl)phenyl functionalized iridium(III) complex is designed and synthesized. The complex shows intensive greenish yellow phosphorescence (525 nm with 563 nm as shoulder), high photoluminescence efficiency (0.90) and moderate full width at half maximum (72 nm). The bulky bis(trifluoromethyl)phenyl moiety introduced into the complex provides the excellent solubility and effective steric hindrance for solution-processed organic light-emitting diodes. The maximum power efficiency and current efficiency of electroluminescence are 4.13 lm/W and 9.54 cd/A, respectively. (C) 2018 Elsevier Ltd. All rights reserved.