5-(4-bromophenyl)-4-(4-bromophenylsulfonyl)-2,2-diphenyl-2,3-dihydrofuran | 1293912-72-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-bromophenyl)-4-(4-bromophenylsulfonyl)-2,2-diphenyl-2,3-dihydrofuran
• 英文别名: 5-(4-bromophenyl)-4-(4-bromophenyl)sulfonyl-2,2-diphenyl-3H-furan
• CAS: 1293912-72-7
• 化学式: C₂₈H₂₀Br₂O₃S
• 分子量: 596.339
• InChiKey: YDWYAIIAMNDVTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(4-bromophenyl)-4-(4-bromophenylsulfonyl)-2,2-diphenyl-2,3-dihydrofuran 、 2-氨基苯甲腈 在 18-冠醚-6 、 palladium diacetate 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以71%的产率得到2-(4-{2-[4-(2-cyanophenylamino)phenyl]-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl}phenylamino)benzonitrile
  参考文献：
  名称：

  Efficient one-pot double Buchwald–Hartwig coupling reaction on 5-phenyl-4-phenylsulfonyl-2,3-dihydrofuran derivatives

  摘要：

  We report a new and efficient method of conducting a one-pot double Buchwald-Hartwig coupling reaction on 2,3-dihydrofuran derivatives bearing two bromine atoms. This rapid and convenient synthesis allows us to access a great variety of original mixed dicoupled compounds. The strategy appears promising for combinatorial chemistry and pharmacomodulation studies. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.049
• 作为产物：
  描述：

  2,4'-二溴苯乙酮 在 copper diacetate 、 manganese triacetate 、 碳酸氢钠 、 sodium sulfite 作用下， 以 水 、 溶剂黄146 为溶剂， 反应 2.08h， 生成 5-(4-bromophenyl)-4-(4-bromophenylsulfonyl)-2,2-diphenyl-2,3-dihydrofuran
  参考文献：
  名称：

  Efficient one-pot double Buchwald–Hartwig coupling reaction on 5-phenyl-4-phenylsulfonyl-2,3-dihydrofuran derivatives

  摘要：

  We report a new and efficient method of conducting a one-pot double Buchwald-Hartwig coupling reaction on 2,3-dihydrofuran derivatives bearing two bromine atoms. This rapid and convenient synthesis allows us to access a great variety of original mixed dicoupled compounds. The strategy appears promising for combinatorial chemistry and pharmacomodulation studies. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.049

文献信息

• Efficient one-pot double Buchwald–Hartwig coupling reaction on 5-phenyl-4-phenylsulfonyl-2,3-dihydrofuran derivatives
  作者：Ahlem Bouhlel、Christophe Curti、Omar Khoumeri、Patrice Vanelle

  DOI：10.1016/j.tetlet.2011.02.049

  日期：2011.4

  We report a new and efficient method of conducting a one-pot double Buchwald-Hartwig coupling reaction on 2,3-dihydrofuran derivatives bearing two bromine atoms. This rapid and convenient synthesis allows us to access a great variety of original mixed dicoupled compounds. The strategy appears promising for combinatorial chemistry and pharmacomodulation studies. (C) 2011 Elsevier Ltd. All rights reserved.