2-丙-2-烯基硫基苯胺 | 77053-20-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 2-丙-2-烯基硫基苯胺
• 英文名称: 2-(2-propen-1-ylsulfanyl)aniline
• 英文别名: 2-amino-S-allylthiophenol；2-(allylthio)aniline；2-allylthioaniline；2-allylmercapto-aniline；2-Allylmercapto-anilin；2-Amino-thiophenol-allylaether；2-prop-2-enylsulfanylaniline
• CAS: 77053-20-4
• 化学式: C₉H₁₁NS
• mdl: MFCD06655714
• 分子量: 165.259
• InChiKey: HDIIJUUMINQFTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  2-丙-2-烯基硫基苯胺 在 titanium(III) chloride 、 lithium 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以47%的产率得到2-氨基苯硫醇
  参考文献：
  名称：

  Shadakshari; Talukdar; Chattopadhyay, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 10, p. 1007 - 1010

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基苯基苯甲基硫代醚 在 titanium(III) chloride 、 lithium 、 potassium carbonate 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 20.0h， 生成 2-丙-2-烯基硫基苯胺
  参考文献：
  名称：

  Shadakshari; Talukdar; Chattopadhyay, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 10, p. 1007 - 1010

  摘要：

  DOI：

文献信息

• Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
  申请人：AVENTIS PHARMA S.A.

  公开号：US20040248884A1

  公开（公告）日：2004-12-09

  The present invention relates to a cyclic urea compound of formula I: 1 as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use, as an inhibitor on a protein kinase. Thus, it is useful for preventing or treating a physiological disorder capable of being modulated by inhibiting the activity of a protein kinase, such as a solid tumor.

  本发明涉及一种如下式的环脲化合物： 1 如本文所定义。该发明还涉及其制备方法，包括它的药物组合物以及其作为蛋白激酶抑制剂的药用，因此，它对于预防或治疗能够通过抑制蛋白激酶活性而调节的生理紊乱是有用的，比如固体肿瘤。
• The Pschorr Cyclization of Aromatic Amines with<i>t</i>-Butyl Thionitrate in Nonaqueous Media
  作者：Shigeru Oae、Kazuyuki Iida、K\={o}ichi Shinhama、Toshikazu Takata

  DOI：10.1246/bcsj.54.2374

  日期：1981.8

  The Pschorr cyclization of various arylamines with t-butyl thionitrate under nonaqueous conditions gave the, corresponding cyclic products in moderate yields. The same reaction was also found to proceed readily with p-toluenesulfonyl nitrite at room temperature. Treatment of o-aminophenyl allyl ether or sulfide with t-butyl thionitrate resulted in the intramolecular Meerwein arylation to the olefinic bond affording 3-chlorochroman or -thiochroman, though the yield was low. The plausible mechanism of the Pschorr cyclization with t-butyl thionitrate is discussed.

  在非水条件下，使用叔丁基亚硝酸酯进行Pschorr环化反应，各种苯胺衍生物能以中等产率得到相应的环状产物。同样，在室温下，使用对甲苯磺酰亚硝酸酯也能容易地进行这一反应。将邻氨基苯基烯丙基醚或硫醚与叔丁基亚硝酸酯反应，可发生向烯键的Meerwein环化反应，得到3-氯色满或3-氯硫色满，尽管产率较低。本文还讨论了叔丁基亚硝酸酯参与Pschorr环化反应的可能机理。
• Indole derivatives as anti-inflammatory agents
  申请人：——

  公开号：US20030130337A1

  公开（公告）日：2003-07-10

  This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: 1 wherein A is a —CH 2 —, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents

  本发明涉及一类化合物，通常为抗炎和镇痛化合物，其由以下式I表示：其中A为—CH2—、—O—、—S—或—S(O)—；其他取代基如规范中定义；或其个别异构体、异构体混合物和其药用可接受盐。该发明还涉及含有这类化合物的药物组合物以及它们作为治疗剂的使用方法。
• Intramolecular Radical Carboaminoxylation of Aryl Amines
  作者：Armido Studer、Marcel Hartmann、Carolin Gerleve

  DOI：10.1055/s-0035-1560770

  日期：——

  Cyclizing radical carboaminoxylation of various aryl amines is presented. The aryl diazonium salts in situ generated from the corresponding aryl amines are reduced by tetra-n-butylammonium iodide (TBAI) to give the corresponding aryl radicals. These aryl radicals undergo 5-exo and 6-exo cyclization. Subsequent trapping with TEMPO or various other nitroxides provides the corresponding cyclized carboaminoxylated

  介绍了各种芳胺的环化自由基羧基氧基化。由相应的芳胺原位生成的芳基重氮盐被四正丁基碘化铵 (TBAI) 还原，得到相应的芳基。这些芳基经历 5-exo 和 6-exo 环化。随后用 TEMPO 或各种其他氮氧化物捕集以中等至非常好的产率提供相应的环化羧基氨基氧化产物。
• Synthesis of 4-(Phenylamino)quinoline-3-carboxamides as a Novel Class of Gastric H+/K+-ATPase Inhibitors.
  作者：Minoru UCHIDA、Kenji OTSUBO、Jun MATSUBARA、Tadaaki OHTANI、Seiji MORITA、Katsuya YAMASAKI

  DOI：10.1248/cpb.43.693

  日期：——

  In search for inhibitors of gastric H+/K+-ATPase, 4-(phenylamino)quinoline-3-carboxamides were synthesized and evaluated for antisecretory activity against histamine-induced gastric acid secretion in rats. These compounds were synthesized by condensation of aniline derivatives with N-substituted 4-chloroquinoline-3-carboxamides, which were obtained from treatment of 4(1H)-quinolinone-3-carboxylic acid

  为了寻找胃H + / K + -ATP酶的抑制剂，合成了4-（苯氨基）喹啉-3-羧酰胺并评估了其对组胺诱导的大鼠胃酸分泌的抗分泌活性。这些化合物是通过将苯胺衍生物与N-取代的4-氯喹啉-3-羧酰胺缩合而合成的，后者是由亚硫酰氯处理4（1H）-喹啉酮-3-羧酸而获得的。大多数化合物抑制大鼠中组胺诱导的胃酸分泌。其中，N-烯丙基-4-（2-乙基苯基氨基）喹啉-3-羧酰胺（4h）是最有效的抑制剂，并且作为候选抗溃疡药的分布最佳。该化合物显示出可逆的K +竞争性胃H + / K + -ATPase抑制活性。