(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-N-(4-methoxyphenyl)penta-2,4-dienamide | 1087058-32-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-N-(4-methoxyphenyl)penta-2,4-dienamide
• 英文别名: (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid p-anisidide；(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(4-methoxyphenyl)penta-2,4-dienamide
• CAS: 1087058-32-9
• 化学式: C₁₉H₁₇NO₄
• 分子量: 323.348
• InChiKey: FQXRYPRMUOTMLF-ZUVMSYQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  胡椒碱 在 氯化亚砜 、 potassium hydroxide 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 26.0h， 生成 (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-N-(4-methoxyphenyl)penta-2,4-dienamide
  参考文献：
  名称：

  Wahab, Aneela; Sultana, Amina; Khan, Khalid Mohammed, Journal of the Chemical Society of Pakistan, 2015, vol. 37, # 5, p. 1008 - 1014

  摘要：

  DOI：

文献信息

• One pot transamidation of <i>N</i>-pivaloyl activated amides with anilines in the absence of catalyst, base and additive
  作者：Ida Angel Priya Samuel Rajan、Saravanakumar Rajendran

  DOI：10.1039/d3nj01490h

  日期：——

  Transamidation of N-pivaloyl activated amides with weakly-nucleophilic amines such as anilines is demonstrated in the absence of catalyst, base and additives. Under the one-pot conditions, amides were activated in situ by the pivaloyl group and were reacted with anilines at toluene reflux temperature to obtain transamidation products in moderate to excellent yields (60–97%).

  在没有催化剂、碱和添加剂的情况下证明了N-新戊酰活化酰胺与弱亲核胺（如苯胺）的转酰胺基作用。在一锅法条件下，酰胺被新戊酰基原位活化，并在甲苯回流温度下与苯胺反应，以中等至优异的收率（60-97%）获得转酰胺基产物。
• Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors
  作者：Payare L. Sangwan、Jawahir L. Koul、Surrinder Koul、Mallepally V. Reddy、Niranjan Thota、Inshad A. Khan、Ashwani Kumar、Nitin P. Kalia、Ghulam N. Qazi

  DOI：10.1016/j.bmc.2008.09.042

  日期：2008.11

  Based on our recent findings that piperine is a potent Staphylococcus aureus NorA efflux pump inhibitor (EPI), 38 piperine analogs were synthesized and bioevaluated for their EPI activity. Twenty-five of them were found active with potentiating activity equivalent or more than known EPIs like reserpine, carsonic acid and verapamil. The inhibitory mechanism of the compounds was confirmed by efflux inhibition assay using ethidium bromide as NorA substrate. The present communication describes the synthesis, bioevaluation and structure related activity of these efflux pump inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.
• Wahab, Aneela; Sultana, Amina; Khan, Khalid Mohammed, Journal of the Chemical Society of Pakistan, 2015, vol. 37, # 5, p. 1008 - 1014
  作者：Wahab, Aneela、Sultana, Amina、Khan, Khalid Mohammed、Sherwani, Sikandar K.、Perveen, Zeba、Taha, Muhammad、Karim, Aneela

  DOI：——

  日期：——