anthranilic acid dibutylamide | 101260-56-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: anthranilic acid dibutylamide
• 英文别名: Anthranilsaeure-dibutylamid；2-amino-N,N-dibutyl benzamide；2-amino-N,N-dibutylbenzamide
• CAS: 101260-56-4
• 化学式: C₁₅H₂₄N₂O
• mdl: MFCD01168909
• 分子量: 248.368
• InChiKey: BGHIWAIZODHKRH-UHFFFAOYSA-N

物化性质

• 沸点：
  406.7±28.0 °C(Predicted)
• 密度：
  1.009±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.533
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  邻氨基苯甲酸 在 氯化亚砜 作用下， 以 乙醚 为溶剂， 反应 5.0h， 生成 anthranilic acid dibutylamide
  参考文献：
  名称：

  Synthesis, antimicrobial evaluation, ot-QSAR and mt-QSAR studies of 2-amino benzoic acid derivatives

  摘要：

  A series of 2-amino benzoic acid derivatives (1-28) were synthesized and evaluated for their in vitro antimicrobial activity against the panel of Gram positive, Gram negative bacterial and fungal strains. The results of antimicrobial studies indicated that, in general, the synthesized compounds were found to be bacteriostatic and fungistatic in action. QSAR studies performed by the development of one target and multi target models indicated that multi-target model was effective in describing the antimicrobial activity as well demonstrated the effect of structural parameters viz. LUMO, (3)chi(v) and W on antimicrobial activity of 2-amino benzoic acid derivatives.

  DOI：

  10.1007/s00044-010-9537-5

文献信息

• Tetrahydro-pyrido-indoles as cholecystokinin and gastrin antagonists
  申请人：Rhone-Poulenc Rorer Pharmaceuticals Inc.

  公开号：US05162336A1

  公开（公告）日：1992-11-10

  Disclosed are tetrahydro-pyrido-indoles having the general formula ##STR1## which are antagonists towards the neuropeptides cholexystokinin and gastrin processing valuable activities for the treatment of cholecystokinin or gastrin-related disorders of the gastrointestinal, central nervous and appetite regulatory systems and their pharmaceutical compositions and processes for their preparation.

  揭示了具有一般公式##STR1##的四氢吡啶吲哚，这些化合物对神经肽胆囊收缩素和胃泌素具有拮抗作用，对治疗胃泌素或与胃泌素相关的胃肠道、中枢神经和食欲调节系统疾病具有宝贵的活性，以及它们的药物组合物和制备方法。
• Azodyestuffs
  申请人：GEN ANILINE WORKS INC

  公开号：US01975402A1

  公开（公告）日：1934-10-02
• TETRAHYDROPYRIDOINDOLES AS CHOLECYSTOKININ AND GASTRIN ANTAGONISTS
  申请人：RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC.

  公开号：EP0491943A1

  公开（公告）日：1992-07-01
• EP0491943A4
  申请人：——

  公开号：EP0491943A4

  公开（公告）日：1996-02-14
• US4163059A
  申请人：——

  公开号：US4163059A

  公开（公告）日：1979-07-31